DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and Pard3b

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_006496361.1	Gene:	Pard3b / 72823	MGIID:	1919301	Length:	1238	Species:	Mus musculus

Alignment Length:	473	Identity:	100/473 - (21%)
Similarity:	172/473 - (36%)	Gaps:	137/473 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 RDASKPLGLALAGHKDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFK 330
            |.:|.|   |...|.|.|.....::|         ..:||  .:::...|| :|:..:|
Mouse   173 RRSSDP---APGPHADAQPSTASLSG---------QSLKP--VVLDSTQNV-ENKEAMN------ 216

  Fly   331 NVDGDKLVMITSRRKPNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKEGF-LGIMVIYG 394
               |::..:: |..:|.||            .||.|          |.|::..||. |||.|:..
Mouse   217 ---GEQAGLL-SLHRPKDE------------LSDMT----------RAVEISGEGDPLGIHVVPF 255

  Fly   395 KHAEVGS--GIFISDLREGSNAELAGV-KVGDMLLAVNQDVTLESNYDDATGLLKRA---EGVVT 453
            ..:..|.  |:||..:.|.|..:..|: :..:.::.:|....|:..:..|..:.::|   ..|:.
Mouse   256 FSSLSGRILGLFIRGIEENSRCKQEGLFQENECIVKINNVELLDKTFAQAQDVFRQAMKSPSVIL 320

  Fly   454 MILLTLKSEE----------------------------------AIKAEKAAEEKKKEEAKKEE- 483
            .:||....|:                                  |:...:|:..:.:|.|..::
Mouse   321 HVLLPQNREQYEKSVIGPLNIFGNNDGASRTKAAPPARGKPGLKAVHLTRASSPEGEEPASPQQS 385

  Fly   484 ---------EKPQEPATAEI------KPNKKILIELKVEKKPMGV---IVCGGKNNHVTTGCVIT 530
                     .||..|:.:.:      |..|||.|:||  |.|.|:   :|....:.|......:.
Mouse   386 KSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIKIDLK--KGPEGLGFTVVTRDSSIHGPGPIFVK 448

  Fly   531 HVYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFRAD----PPE 591
            ::.|:|....|.||:..|.|.::||..: .|......|..|..|...:.|:|.:.|.:    |.|
Mouse   449 NILPKGAAVKDGRLQSGDRILEVNGRDV-TGRTQEELVAMLRSTKQGETVSLVIARQEGSFLPRE 512

  Fly   592 LE----------------KFNVDLMKKAGKELGLSLSPN-------EIGCTIADLIQGQYPEIDS 633
            |:                ...:.|.......||:||..|       ::|..|..:|.|.....|.
Mouse   513 LKGEPDCYALSLESSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 577

  Fly   634 KLQRGDIITKFNGDALEG 651
            :|:..|.:...||:.|.|
Mouse   578 RLRMNDQLIAVNGETLLG 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492	15/73 (21%)
		PDZ_signaling	377..457	CDD:238492	20/86 (23%)
		PDZ_signaling	500..584	CDD:238492	24/86 (28%)
		PDZ_signaling	597..672	CDD:238492	17/62 (27%)
Pard3b	XP_006496361.1	DUF3534	2..74	CDD:338230
		PDZ_signaling	236..323	CDD:238492	21/96 (22%)
		PDZ	415..504	CDD:214570	26/91 (29%)
		PDZ_signaling	536..624	CDD:238492	17/60 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900