Protein Alignment inaD and TJP1

DIOPT Version :9

• Sequence 1: NP_001246470.1
• Gene: inaD / 37629
• FlyBaseID: FBgn0001263
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_016878010.1
• Gene: TJP1 / 7082
• HGNCID: 11827
• Length: 1878
• Species: Homo sapiens
• Alignment Length: 757
• Identity: 139/757 - (18%)
• Similarity: 246/757 - (32%)
• Gaps: 286/757 - (37%)

  Fly    28 HMVTLDKTGKKSFGICIVRGEVKDSPNTKT--TGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKD 90
            |.|||.:.....|||.|..|  :|:|:.::  |.|.|..::...||.  |:|:..||:..:||..
Human   115 HTVTLHRAPGFGFGIAISGG--RDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVS 175

  Fly    91 VRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASGGQ 155
            :.|......:..::::....::.|:...|.....::.||              |..::|
Human   176 MDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDP--------------EPVSDN------ 220

  Fly   156 GMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRI-----RTEAGY 215
                                              :..:| ||:..|.|  :||.     |:|..:
Human   221 ----------------------------------EEDSY-DEEIHDPR--SGRSGVVNRRSEKIW 248

  Fly   216 EIDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGHK 280
            ..||:::....|:.:...|.......     ||..| ..::|..:..|        .||.||.|
Human   249 PRDRSASRERSLSPRSDRRSVASSQP-----AKPTK-VTLVKSRKNEE--------YGLRLASH- 298

  Fly   281 DRQKMACFVAGVDPNG-ALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMITSR- 343
                  .||..:..:. |....:|:.||.::::||.|.:|....:|..:.:...| ||.|:..|
Human   299 ------IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKG-KLKMVVQRD 356

  Fly   344 --------------------------------------------------RKPN----------- 347
                                                              |.|:
Human   357 ERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRH 421

  Fly   348 -------------DE------GMCVKPIK-------------------KFPTASDETKFIFDQF- 373
                         ||      |....|:|                   |...:..|.|.::.|.
Human   422 SPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVG 486

  Fly   374 --------------------------PKARTVQVRKEGFLGIMVIYGKHAEVGSGIFISDLREGS 412
                                      |..:.|:.||...:|:.:..|...    |||::.:.|.|
Human   487 QPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDV----GIFVAGVLEDS 547

  Fly   413 NAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKE 477
            .|...|::.||.:|.||.        .|.|.:: |.|.|:.::.|....|..|.|     :|||:
Human   548 PAAKEGLEEGDQILRVNN--------VDFTNII-REEAVLFLLDLPKGEEVTILA-----QKKKD 598

  Fly   478 EAKKEEEKPQEPATAEIKPNKKILIELKVEKK-PMGVIVCGGKNNHVTTGCVITHVYPEGQVAAD 541
            ..::..|       :::..:..|....:.||: |.|:                  .:.:|:|
Human   599 VYRRIVE-------SDVGDSFYIRTHFEYEKESPYGL------------------SFNKGEV--- 635

  Fly   542 KRLKIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFRADPPELEKFNVDLMKKAGKE 606
              .::.|.:  .||   .:||...:::.: .|...|:.:.....||:  :|......|.|.||.:
Human   636 --FRVVDTL--YNG---KLGSWLAIRIGK-NHKEVERGIIPNKNRAE--QLASVQYTLPKTAGGD 690

  Fly   607 -------LGLSLSPNEIGCTIADL----IQGQYPEIDSKLQR 637
                   .||..|...:..:..||    :|.::|..:..:.|
Human   691 RADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLR 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	23/88 (26%)
		PDZ_signaling	259..340	CDD:238492	20/81 (25%)
		PDZ_signaling	377..457	CDD:238492	22/79 (28%)
		PDZ_signaling	500..584	CDD:238492	14/84 (17%)
		PDZ_signaling	597..672	CDD:238492	12/52 (23%)
TJP1	XP_016878010.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4314
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950