DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and Slc9a3r2

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_075542.2	Gene:	Slc9a3r2 / 65962	MGIID:	1890662	Length:	337	Species:	Mus musculus

Alignment Length:	481	Identity:	90/481 - (18%)
Similarity:	151/481 - (31%)	Gaps:	182/481 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PELIHMVTLDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNG 88
            |.|..:|    .|::.:|..: .||      ....|.||:.:.|.|||. ...|:.|||::.:||
Mouse     9 PRLCRLV----RGEQGYGFHL-HGE------KGRRGQFIRRVEPGSPAE-AAALRAGDRLVEVNG 61

  Fly    89 KDVRNSTEQAVIDLIKEADFKIELEIQTFDK-SDEQQAK------SDPRSNGYMQAKNKFNQEQT 146
            .:|...|...|:..||..:.:.:|.:  .|| :||:..:      .:....|...|.|.:  |..
Mouse    62 VNVEGETHHQVVQRIKAVEGQTQLLV--VDKETDEELCRRQLTCTEEMAHRGLPPAHNPW--EPK 122

  Fly   147 TNNNASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRT 211
            .:...||..|...||....|                                  ..|::..|:
Mouse   123 PDWACSGSLGSDTGQKDVNG----------------------------------PPRELRPRL-- 151

  Fly   212 EAGYEIDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLAL 276
                         |.|.:                                        .|.|...
Mouse   152 -------------CHLRR----------------------------------------GPQGYGF 163

  Fly   277 AGHKDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMIT 341
            ..|.|:.:...::..|||........::..|.::||||               :||:|.:...:.
Mouse   164 NLHSDKSRPGQYIRSVDPGSPASHSGLRAQDRLIEVNG---------------QNVEGLRHAEVV 213

  Fly   342 SRRKPNDEGMCVKPIKKFPTASDETKFIF------DQFPKARTVQVRK--EGFLGIMVIYG-KHA 397
            :|.|..:               ||.:.:.      :.|.:.|.:...:  ||.|...|..| ..|
Mouse   214 ARIKAQE---------------DEARLLVVDPETDEHFKRLRVIPTEEHVEGPLPSPVTNGTSPA 263

  Fly   398 EVGSGIFISDLREGSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSE 462
            ::..|...|     |.::|.|.:              :.|.|.:|  .||.....:.:.|
Mouse   264 QLNGGSVCS-----SRSDLPGSE--------------KDNEDGST--WKRDPFQESGLHL----- 302

  Fly   463 EAIKAEKAAEEKKKEEAKKEEEK-PQ 487
                :..|||.|:|..|.:..:: ||
Mouse   303 ----SPTAAEAKEKARATRVNKRAPQ 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	24/87 (28%)
		PDZ_signaling	259..340	CDD:238492	15/80 (19%)
		PDZ_signaling	377..457	CDD:238492	17/82 (21%)
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
Slc9a3r2	NP_075542.2	PDZ_signaling	9..88	CDD:238492	26/92 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..147		10/70 (14%)
		PDZ	148..230	CDD:214570	22/166 (13%)
		EBP50_C	232..337	CDD:286142	27/123 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..337		25/113 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900