DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and Pdzk1

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_113900.1	Gene:	Pdzk1 / 65144	RGDID:	70924	Length:	523	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	130/661 - (19%)
Similarity:	214/661 - (32%)	Gaps:	221/661 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDVRNSTE 96
            |.|...:::|. .:|.| ||     |.|..::.|...|||...|.|. |||:|.:||..|.....
  Rat    12 LSKKEGQNYGF-FLRIE-KD-----TDGHLVRVIEEGSPAEKAGLLD-GDRVLRINGVFVDKEEH 68

  Fly    97 QAVIDLIKEADFKIELEI---QTFDKS-----DEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASG 153
            ..|:||::::...:.|.:   .:::|:     |.::....||.....:.|...
  Rat    69 AQVVDLVRKSGNSVTLLVLDGDSYEKAVKHQVDLKELDQSPREPALNEKKPDL------------ 121

  Fly   154 GQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYEID 218
                           |||                                   |.:.|.|...:
  Rat   122 ---------------GMN-----------------------------------GGVETCAQPRL- 135

  Fly   219 RASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGHKDRQ 283
                  |.|.|        :.:.||:::..|                                :.
  Rat   136 ------CYLVK--------EGNSFGFSLKTI--------------------------------QG 154

  Fly   284 KMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNV--DGDKLVMI-----T 341
            |...|:..:.|.|......:...|.::||||..::|..|   ..|.:.|  .|.:::.:     |
  Rat   155 KKGVFLTDITPQGVAMKAGVLADDHLIEVNGENVENASH---EEVVEKVTKSGSRIMFLLVDKET 216

  Fly   342 SRRKPNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVG---SGI 403
            :|.....:    .|.|: .|||      ....|....|.|.|:|..|    ||.:...|   .|.
  Rat   217 ARCHSEQK----TPFKR-ETAS------LKLLPHQPRVVVIKKGSNG----YGFYLRAGPEQKGQ 266

  Fly   404 FISDLREGSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAE 468
            .|.|:..||.||.||:|..|:::|||.:.....::|....:::......|:::|..:::......
  Rat   267 IIKDIEPGSPAEAAGLKNNDLVVAVNGESVEALDHDSVVEMIRNGGDQTTLLVLDKEADRIYSLA 331

  Fly   469 K-------AAEEKKKEEAKKEE-------EKPQEPATAEIKPNKKILIELKVEKKPMGVIVCGGK 519
            :       .::|......|:..       |.|....|.::..:|..|..|..|....|.
  Rat   332 RFSPLLYCQSQELPNGSVKEAPAPISAPLEAPGSATTEDVGDHKPKLCRLIKEDDSYGF------ 390

  Fly   520 NNHVTT-----GCVITHVYPEGQVAADKR-LKIFDHICDINGTPIH-------------VGSMTT 565
              |:..     |..:..|...|  .|||. |:..|.|.::||..:.             .|...|
  Rat   391 --HLNAIRGQPGSFVKEVQQGG--PADKAGLENEDIIIEVNGENVQDEPYDRVVERIKSSGEHVT 451

  Fly   566 LKVHQLFHTTYEKAVTLTVFR--ADPPELEKFNVDLMKKAGKELGLSLSPNEIGCTIADLIQ--- 625
            |.|......:|.:|..:.:..  |||                   |...|:|.|.|..|..:
  Rat   452 LLVCGKVAYSYFQAKKIPILSSLADP-------------------LVAGPDEKGETEHDSAESTK 497

  Fly   626 -GQYPEIDSKL 635
             ..:|..|..|
  Rat   498 DSSHPARDRTL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	26/85 (31%)
		PDZ_signaling	259..340	CDD:238492	14/82 (17%)
		PDZ_signaling	377..457	CDD:238492	24/82 (29%)
		PDZ_signaling	500..584	CDD:238492	22/102 (22%)
		PDZ_signaling	597..672	CDD:238492	9/43 (21%)
Pdzk1	NP_113900.1	PDZ_signaling	7..87	CDD:238492	26/82 (32%)
		PDZ	132..212	CDD:214570	20/129 (16%)
		PDZ_signaling	242..320	CDD:238492	24/81 (30%)
		PDZ	375..455	CDD:214570	20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..523		8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810