DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_038959013.1	Gene:	Pdzd2 / 65034	RGDID:	619958	Length:	2818	Species:	Rattus norvegicus

Alignment Length:	836	Identity:	175/836 - (20%)
Similarity:	277/836 - (33%)	Gaps:	255/836 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HNPFPEL-IHMVTLDK------TGKKSFGICIVRGE------------VKDSPNTKTTGIFIKGI 65
            |:| ||: |..|.|.|      |...|||...|.|:            ....|......|::..:
  Rat    61 HSP-PEMEICTVYLTKQLGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIWVTEL 124

  Fly    66 VPDSPAHLCGRLKVGDRILSLNGK-----DVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQA 125
            ..:|||...|::::.|.||||||:     ||..::..|
  Rat   125 RKNSPAGKSGKVRLRDEILSLNGQLMVGVDVTGASYLA--------------------------- 162

  Fly   126 KSDPRSNG---YMQAKNKFNQEQTTNNNASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASM 187
              :...||   |:....:|.|:.....|.:.|.....|:.....:.....::.  ||...|....
  Rat   163 --EQCWNGGFIYLIMLRRFKQKAHVTYNGNSGNSSEPGETPTLELGDQTSKKG--KRTRKFGVIS 223

  Fly   188 R---------QKHSNYADEDDEDTRDMTG-------------------RIRTEAGYEIDRASAGN 224
            |         .|.|:..|..|:...::..                   .::..||..::|:.|.:
  Rat   224 RPSISKTPEDSKSSSGCDTADDPNSELENGADPELGNGHAFELENGPHSLKDVAGPHLERSEADS 288

  Fly   225 ---CKLNKQE----KDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQR-------DASKPLGLA 275
               .::.|.|    ...||.:..:.|.|      .:.....|.|.||.|       ..|..||:.
  Rat   289 EVELRVPKTEAPLSDSNDKRRFSKTGKT------DFQSSDCLAREEVGRIWKMELLKESDGLGIQ 347

  Fly   276 LAGHK--DRQKMACFVAGVDPNGAL---GSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDG- 334
            ::|.:  .|...|..|..|...||.   |.:.:  |||::.:||::|....|..|.|:.::..|
  Rat   348 VSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSL--GDELLVINGHLLVGLSHEEAVAILRSATGM 410

  Fly   335 ------------DKLVMITSRRKPNDEGMCVKPIKKFPTASDETKFIFDQ---FPKARTVQVRKE 384
                        :.|:.:||:..| |....|:.:..:....|:.....|:   .|.|  |:|...
  Rat   411 VQLVVASKESSAEDLLKLTSKSLP-DLTSSVEDMSSWTDNEDQEAAGEDEEGSGPAA--VRVTMP 472

  Fly   385 GFLGIMVIYGKHAEVGSGIFISDLREGSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAE 449
            |       ..:..:|||.       |.|...|...|.|      |....|:|.   .:|.:.|.|
  Rat   473 G-------SEESQDVGSS-------EESKGNLESPKQG------NCKTKLKSR---LSGGVHRLE 514

  Fly   450 GVVTM-ILLTLKSEEAIKAEKAAEEKKKEEAK---------------KEEEKPQEPATAE----- 493
            .|... .|:....:..|:..:.:.:.:|....               |:..:.......|
  Rat   515 SVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSTGTSQEYHIVKKSTRSLSTTHVESPWRL 579

  Fly   494 IKPNKKILIELKVEK-KPMGVIVCGGKNNHVTTGCV-------ITHVYPEGQVAADKRLKIFDHI 550
            |:|:...:|.|..|| |.:|..:.||::      |:       :..::|.|..|.|.|||..|.|
  Rat   580 IRPSVISIIGLYKEKGKGLGFSIAGGRD------CIRGQMGIFVKTIFPNGSAAEDGRLKEGDEI 638

  Fly   551 CDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTV------------------FRADPPELEKFN- 596
            .|:||.||.  .:|..:....|.........|||                  .|:..|   .||
  Rat   639 LDVNGIPIK--GLTFQEAIHTFKQIRSGLFVLTVRTKLLSPSLTPCSTPTHMSRSSSP---SFNT 698

  Fly   597 ---------------------------------VDLMKKAGKELG-----LSLSPNEIGCTIADL 623
                                             |.|.|:....||     |:|..:..|..|..|
  Rat   699 NSGGTPAGGGQEEGGSSSLGRKAPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSL 763

  Fly   624 IQGQYPEIDSKLQRGDIITKFNGDALEGLPFQVCYA-LFKGANGKVSMEVTR-PKP 677
            ..|...:::|.|.|||.|.:.|...:........:| |.|...|.|.:.:.| |.|
  Rat   764 APGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNP 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	26/110 (24%)
		PDZ_signaling	259..340	CDD:238492	27/105 (26%)
		PDZ_signaling	377..457	CDD:238492	18/80 (23%)
		PDZ_signaling	500..584	CDD:238492	26/91 (29%)
		PDZ_signaling	597..672	CDD:238492	23/80 (29%)
Pdzd2	XP_038959013.1	PDZ_signaling	335..416	CDD:238492	21/82 (26%)
		PDZ_signaling	590..671	CDD:238492	26/88 (30%)
		PDZ_signaling	729..813	CDD:238492	23/83 (28%)
		PHA03247	<985..1446	CDD:223021
		PDZ_signaling	2603..2677	CDD:238492
		PDZ_signaling	2731..2813	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810