DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and stxbp4

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_009305072.1	Gene:	stxbp4 / 567916	ZFINID:	ZDB-GENE-110420-5	Length:	749	Species:	Danio rerio

Alignment Length:	646	Identity:	133/646 - (20%)
Similarity:	220/646 - (34%)	Gaps:	209/646 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KKSFGICIV---RGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDVRNSTEQA 98
            ||..|:.|:   ||:     :.:..|||||.|:|...|...|||:.||.||.:|..::|..|.:.
Zfish    42 KKGLGVKIIGGYRGQ-----SGEEFGIFIKRILPGGVAAQDGRLRPGDLILDVNNMNLRGVTNEK 101

  Fly    99 VIDLIKEADFKIELEI---------QTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASGG 154
            .:::::.|.....:.:         :.|.:..|:...|...|:|...:.:......|.::::|..
Zfish   102 AVEVLRMASATNHMSLLVVRDDASRREFTELMEKYGSSSSTSSGSDTSVSTGKMTDTASSSSSSR 166

  Fly   155 ----------------------------------QGMGQGQGQGQGM---AGMNR--------QQ 174
                                              |.:...:|.|.|:   .|.||        |:
Zfish   167 STSPLLLSPKEPSPVYTTACINSPSPQVCTDCMIQLICVAKGTGLGLVIRGGANRAEGPMVFVQE 231

  Fly   175 SMQKRNTTFTASMRQKHSNYADEDD--------------EDTRDMTGR--IRTEAGYEI----DR 219
            .:|..:.       ||.......|.              |:.:.:..|  :|.:...||    .|
Zfish   232 IIQGGDC-------QKDGRLKSGDQLISINKESLVGVTHEEAKSILTRTKLRPDPTVEIAFIRRR 289

  Fly   220 ASAG-------------NCKLN---KQEKDRDKEQEDEFGYTMAKI----NKRYNMMKDLRRIEV 264
            :|:|             :|..|   .|.|..........|..:.||    |.....:..:...:|
Zfish   290 SSSGSSSGPHSPISLQPSCSTNHPAPQTKPSGLSGAALPGGLVPKIANTPNSGSETLPSVELTKV 354

  Fly   265 QRDASKPLGLALAGHKDRQKMACFVAGVDPNGA------------LGSVDIKPG--DEIVEVNG- 314
            :....||:   ||.....:.....||..|.:.|            :.|.::||.  |:.:||.|
Zfish   355 RAATGKPV---LAPVTSPESACTTVANADASAACNPSRPSKPLCSVQSFELKPEKIDQTLEVLGL 416

  Fly   315 -------NVLKNRCHLNASA-------------VFK---NVDGD-KLVMITSRRKPNDEGMCVKP 355
                   ..|:.|..|||..             :||   .:|.: ::..:||      :.:...|
Zfish   417 KPADSQVLTLRERLRLNAGGTVAYGDFDTVTKELFKQPSKLDSEQEVARLTS------DDLIESP 475

  Fly   356 IKKFPTASDETKFIFDQFPKARTVQVRKEGFLGIMVIYG---KHAEVGSGIFISDLREGSNAELA 417
            ....|:.||...  .|:..:     :|||....:..:.|   |.||..|      |......||.
Zfish   476 SNPTPSLSDSDD--LDEMER-----LRKEHIEALRELKGLQDKLAESES------LNHKMLQELT 527

  Fly   418 GVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKA--AEEK--KKEE 478
            .|| .|...||.:..:|.:....|....|:|.|      :.:..||.|...:|  ||.|  |.|:
Zfish   528 KVK-QDAKSAVEESRSLRTRIHLAEAAQKQARG------MEMDYEEVIHLLEAEIAEMKSLKTEQ 585

  Fly   479 AKKEEEKPQEPATAEIKPNKKILIELKVEKKPMGVIVC-------GGKNNHVTTGCVITHV 532
            ..:|:|                  :|:..||.:.|:.|       ..|...|:||.::..|
Zfish   586 PSQEKE------------------DLQDLKKRISVLECQLRKSEVAKKGFQVSTGKLLQFV 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	25/89 (28%)
		PDZ_signaling	259..340	CDD:238492	24/119 (20%)
		PDZ_signaling	377..457	CDD:238492	21/82 (26%)
		PDZ_signaling	500..584	CDD:238492	10/40 (25%)
		PDZ_signaling	597..672	CDD:238492
stxbp4	XP_009305072.1	PDZ_signaling	40..120	CDD:238492	25/82 (30%)
		PDZ_signaling	207..274	CDD:238492	13/73 (18%)
		RILP-like	486..585	CDD:304877	30/118 (25%)
		WW	695..724	CDD:278809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100