DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and pdzd3b

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001124259.1	Gene:	pdzd3b / 566852	ZFINID:	ZDB-GENE-081022-151	Length:	524	Species:	Danio rerio

Alignment Length:	639	Identity:	123/639 - (19%)
Similarity:	210/639 - (32%)	Gaps:	217/639 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GMHNPFPELIHMVTLDKTGK---KSFGICIVRGEVKDS------PNTKTTGIFIKGIVPDSPAHL 73
            |:.||.     |||.|:|.:   .:..:|::|.|.:::      ......|..|:.:....||..
Zfish    24 GIDNPV-----MVTADETERVWNPTPRVCVLRREERETFGFHLRVERDRQGHVIRLLDSPGPAAR 83

  Fly    74 CGRLKVGDRILSLNGKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQAK 138
            .| ||.|||:|.:|         :|.::
Zfish    84 SG-LKDGDRLLEVN---------EAFVE------------------------------------- 101

  Fly   139 NKFNQEQTTNNNASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTR 203
               |.|.|   ..||.|                         ..|.. :.:|.......:..|.|
Zfish   102 ---NLEHT---EVSGSQ-------------------------ICFLV-LDEKAYEQVVSEGRDLR 134

  Fly   204 DMTGRIRTEAGYEIDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDA 268
            :|....|.| |:.....    |.:.|          |..|       ..:|:
Zfish   135 EMAKAARGE-GWRPPHL----CHIRK----------DAHG-------MGFNI------------- 164

  Fly   269 SKPLGLALAGHKDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVD 333
                 |.:.|.|.:     |.......||.....::.||.::.::|.:.....|...|.:.|...
Zfish   165 -----LPVEGEKRK-----FAVSPVKGGAAERAGVRKGDHLIWIDGAMASELTHSAISKMVKKCS 219

  Fly   334 GDKLVMIT--------SRRKPNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKEGFLGIM 390
            ....|::.        :|||        .||  .|..:|.....:.  |:...:.:..:|: |.:
Zfish   220 SHMTVLVIDSDTEKSYARRK--------MPI--LPAMADAENMPYR--PQRLHLVMGPDGY-GFL 271

  Fly   391 VIYGKHAEVGSGIFISDLRE---GSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVV 452
            :   :..:.|:|..:..:||   ||.|||.|||.|:|||.||.:.|...::.|....::::...|
Zfish   272 L---RQEKGGAGRTVHMVREVDKGSPAELGGVKEGEMLLEVNGESTDPLSHKDVVSNIRQSGQQV 333

  Fly   453 TMILLTLKSEE------------AIKAEKAAEEKKKE--EAKKEEEKPQEP-ATAEIKPN-KKIL 501
            |:..:|.:..:            .:....|..|.|||  ...|....|.|| ...:|.|| ::.:
Zfish   334 TLTTMTPQGYDFYTKLGLSPLLFCVDVPSALPEVKKEIPVTPKPAVPPVEPQEEVQINPNVRRCI 398

  Fly   502 IELK----------VEKKPMGVIVCGGKNNHVTTGCVITHVYPEGQVAADKRLKIFDHICDINGT 556
            :|..          |::||               |..|:.| ..|.......|...|.:.::||.
Zfish   399 LERSSAGFGFHLGCVQQKP---------------GTFISQV-AAGSPGQSSGLFQGDVVVEVNGQ 447

  Fly   557 PIHVGSMTTLKVHQLFHTTYEKAVTLTVFRADPPELEKFNVDLMKKAGKELGLS 610
            .:...|:..:.:|     ......||::...|     :...|.:|:.||.:.|:
Zfish   448 NVEKESLEDVIMH-----VKRGGETLSLLVVD-----QKGYDWLKQNGKPVTLN 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	21/96 (22%)
		PDZ_signaling	259..340	CDD:238492	13/80 (16%)
		PDZ_signaling	377..457	CDD:238492	24/82 (29%)
		PDZ_signaling	500..584	CDD:238492	16/93 (17%)
		PDZ_signaling	597..672	CDD:238492	5/14 (36%)
pdzd3b	NP_001124259.1	PDZ_signaling	44..118	CDD:238492	23/152 (15%)
		PDZ	148..227	CDD:214570	18/122 (15%)
		PDZ_signaling	264..336	CDD:238492	24/75 (32%)
		PDZ	393..473	CDD:214570	17/100 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900