DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and grip2b

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_021325304.1	Gene:	grip2b / 562290	ZFINID:	ZDB-GENE-070705-172	Length:	1086	Species:	Danio rerio

Alignment Length:	814	Identity:	160/814 - (19%)
Similarity:	278/814 - (34%)	Gaps:	279/814 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VTLDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDVRNS 94
            :.|.|.| .|||. ::||...:..: |:..:.:..:.|..||...|.||.||||||::|..:.::
Zfish   148 ICLQKEG-NSFGF-VMRGGAHEDWH-KSRPLVVTHVRPGGPADREGTLKSGDRILSVDGVVLHSA 209

  Fly    95 TEQAVIDLI----KEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASGG- 154
            |....:.::    :||.|:||.::...|                            :..||||.
Zfish   210 THSDALVVLTQCGQEALFQIEYDVSIMD----------------------------SVTNASGPL 246

  Fly   155 -QGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADE-DDEDTRDMTGRIRT-EAGYE 216
             ..:.:..|...|:             |..||..|.|.:...|: ......|.:|.:.. :....
Zfish   247 LVEIAKAPGASLGV-------------TLTTALHRNKQAIVIDKIKPGSVVDRSGALHVGDHILS 298

  Fly   217 IDRASAGNCKL-------------NKQE-------------KDRDKEQEDEF------------- 242
            ||..|..:|.|             .|.|             :|..|.|:.:.
Zfish   299 IDGTSTEHCSLLEATQLLASTSDQTKLEILPAHQTRLPGKPQDTVKVQKSDHPHCWDPCVNYCHS 363

  Fly   243 ---------GYTMAKIN------------------------------------------KRYNMM 256
                     .:|.|..|                                          .|.:|:
Zfish   364 QHPGHCKTSTWTSASSNPSSSQDYCKSVVCSNFSPGSTTTSGMTSQGSSTLPRAAPPMSPRNSML 428

  Fly   257 KDLRRIEVQRDASKPLGLALAG------HKDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGN 315
            |..:|.:..:.:|..|..:..|      |.:..::.  :.| ||....|          |::.|.
Zfish   429 KRRQRKKEHKSSSVSLASSSVGPGGQIVHTESSEVT--LRG-DPLNGFG----------VQLQGG 480

  Fly   316 VLKNRCHLNASAVFKNVD-------------GDKLVMITSRRKPNDEGMCVKPIKKFPTASDETK 367
            :..... |:|..:.:.::             ||:::.|..  .|.::|...:..:....|:...|
Zfish   481 IFATET-LSAPPLIRFIEPDSSAERCGLLQVGDRVLSING--IPTEDGTLEEANQLLRDAALANK 542

  Fly   368 FIFD-QF-------PKARTVQV---RKEGF-LGIMVIYGKHAEVGSGIFISDLREGSNAELAG-V 419
            ...: :|       |.:.|..|   :|.|. |||.:...|  :.|..:.|||:::||.|...| :
Zfish   543 VSLEIEFDVAESVVPSSGTFHVKLQKKRGVELGITISASK--KPGEPLIISDIKKGSMAHRTGTL 605

  Fly   420 KVGDMLLAVNQDVTLES-NYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEE 483
            :.||.|||:: ::.||: :.:||..:|:::|.:|.:.:                  :|:|...:|
Zfish   606 EPGDKLLAID-NIRLENCSMEDAAQILQQSEDLVKLKI------------------RKDEDNSDE 651

  Fly   484 EKPQEPATAEIKPNKKILIELKVEKKPMGVIVCGGKNNHVTTGCVITHVYPEGQVAADKRLKIFD 548
               ||.:.:.|     ..:|||....|:|:.:.|  ........:|:.:...|.......:.:.|
Zfish   652 ---QESSGSII-----YTVELKRYGGPLGITISG--TEEPFDPIIISGLTKRGLAERTGAIHVGD 706

  Fly   549 HICDIN-----GTP----IHV----GSMTTLKVHQLFHTTYEKAVTLTVFRADPPELEKFNVDLM 600
            .|..||     |.|    ||:    |...|||:.:               :||.|:        .
Zfish   707 RILAINSVSLKGKPLSEAIHLLQMAGETVTLKIKK---------------QADSPD--------E 748

  Fly   601 KKAGKELGLSLSPNEIGCT-------IADLIQGQYPEIDSKLQRGDIITKFNGDALE-GLPFQVC 657
            |....:|...||.||...|       ::|:.....|.:||.::..|      |..:: |...|..
Zfish   749 KNKENDLENDLSDNEDEMTDSQKTNKLSDIYSTTIPSVDSAMESWD------GSGIDAGYSSQGA 807

  Fly   658 Y-------ALFKGANGKVSMEVTRPKPTLRTEAP 684
            :       ||............:.|.||.|...|
Zfish   808 FIHQAAGIALHPHEWRNTKQRNSTPPPTRRKNYP 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	28/88 (32%)
		PDZ_signaling	259..340	CDD:238492	15/99 (15%)
		PDZ_signaling	377..457	CDD:238492	28/85 (33%)
		PDZ_signaling	500..584	CDD:238492	20/96 (21%)
		PDZ_signaling	597..672	CDD:238492	17/89 (19%)
grip2b	XP_021325304.1	PDZ_signaling	45..127	CDD:238492
		PDZ	144..232	CDD:214570	28/86 (33%)
		PDZ_signaling	245..328	CDD:238492	17/95 (18%)
		PDZ_signaling	462..548	CDD:238492	15/101 (15%)
		PDZ_signaling	561..643	CDD:238492	28/102 (27%)
		PDZ_signaling	659..740	CDD:238492	21/87 (24%)
		Peptidase_S41	672..>841	CDD:321971	40/199 (20%)
		PDZ_signaling	970..1050	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910