DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaD and lnx1

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_005160562.1	Gene:	lnx1 / 561226	ZFINID:	ZDB-GENE-030131-9439	Length:	769	Species:	Danio rerio

Alignment Length:	591	Identity:	122/591 - (20%)
Similarity:	213/591 - (36%)	Gaps:	131/591 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 SMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYEIDRASAGNCKLNKQEKDRDK--- 236
            |.....|:..|....:.|.|.:.|....|..:.|....|...:.|..:|....|...::||.
Zfish   209 SQSGSTTSLAARSGSRKSEYRNFDRTSVRSRSFRRLNRAFSVLRRTKSGTAVANDTTEERDNLRN 273

  Fly   237 ---EQEDEFGYTMAKINKRYNMMKD--LRRIEVQR-DASKPLGLALAGHKDRQKMACFVAGVDPN 295
               ..|.|    :..:.:.::::.|  :..|::.| |..:||.:::.|..:...:...:..:...
Zfish   274 ANIPAEGE----LFALPQLHHLIPDGEVTSIKITRADPCEPLAISIVGGNETPLVRILIQDIYRE 334

  Fly   296 GALG-SVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMITSRRKPNDEGMCVKPIKKF 359
            |.:. ...:.|||.|::|||..:.|..|..|.|..|  ....|:.:|..|:....   .:.....
Zfish   335 GVIARDGRLLPGDMILKVNGIDISNVPHCYAVAALK--QPCTLLRLTVLREQRHR---YRSHHHS 394

  Fly   360 PTASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVG---------SGIFISDLREGSNAE 415
            ||         :.|| |.|..:|.:....::|......::|         .|:||..|.||..|.
Zfish   395 PT---------EAFP-AHTATIRDDSLHVVLVKRAPDEQLGIKLVRRPDEHGVFIFHLLEGGLAA 449

  Fly   416 LAG-VKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEA 479
            ..| ::|.|.:||:|.........:.|..|::.:|..|..|   :..:..|.|....     :||
Zfish   450 RDGRLRVDDRVLAINGHDLRYGAPEHAALLIQASEDRVHFI---VSRQTHIPAPDIL-----QEA 506

  Fly   480 KKEEEKP----------------QEPATAEIKPNKKILIELKVEKKPMGVIVCGGKNNHVTTG-- 526
            ....|.|                |:||..|     |.:..||.....:|:.|.||.::.   |
Zfish   507 PWNMEGPPPYSPVDIEHTLLDSCQKPACYE-----KTVTLLKEPHDSLGMTVAGGMSSR---GWD 563

  Fly   527 --CVITHVYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFRADP 589
              ..:|:|.|.|.|..:..::..|.:.::||..: .|...:..|..|.:|:  ..|.|.|....|
Zfish   564 LPVYVTNVDPNGVVGQEGSIRKGDILLNVNGVDL-TGVTRSEAVANLKNTS--SPVVLQVLEMRP 625

  Fly   590 P-------------------------ELEKFNVD----------------------LMKKAGKEL 607
            |                         :|...|.|                      |.:.....|
Zfish   626 PNESSLDCMPPLHSPCALSPSSPGDVKLPPPNDDYAPLWVSWLQLPRHLYCCKDIVLRRSTSGSL 690

  Fly   608 GLSL--SPNEIGCT----IADLIQGQYPEIDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANG 666
            |.|:  ...|:.|.    |..:::|.....|.:::.|||:.:.||.:..|:.......|.|...|
Zfish   691 GFSIVGGQEELNCNQSFFIRSIVEGTPAYNDGRIRCGDILLEVNGKSTWGMTHTALVRLLKELRG 755

  Fly   667 KVSMEV 672
            ::::.:
Zfish   756 RITLTI 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492	20/82 (24%)
		PDZ_signaling	377..457	CDD:238492	22/89 (25%)
		PDZ_signaling	500..584	CDD:238492	21/87 (24%)
		PDZ_signaling	597..672	CDD:238492	19/102 (19%)
lnx1	XP_005160562.1	RING	57..93	CDD:214546
		PDZ_signaling	297..381	CDD:238492	21/85 (25%)
		PDZ_signaling	411..491	CDD:238492	20/82 (24%)
		PDZ_signaling	536..621	CDD:238492	23/95 (24%)
		DegQ	<548..621	CDD:223343	19/78 (24%)
		PDZ_signaling	678..762	CDD:238492	18/84 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910