DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and pdzd3a

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_685398.3	Gene:	pdzd3a / 557269	ZFINID:	ZDB-GENE-080430-1	Length:	520	Species:	Danio rerio

Alignment Length:	480	Identity:	98/480 - (20%)
Similarity:	179/480 - (37%)	Gaps:	142/480 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 LRRIEVQ-------RDASKPLGLALAGHKDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNV 316
            |||.|.|       |||.:     ..||..||        |:|..:.....::.||.::|||.:.
Zfish    66 LRREEGQGFGFYLSRDAGR-----CRGHVVRQ--------VEPWSSAERAGLRIGDHVLEVNEDF 117

  Fly   317 LKNRCH------LNASAV-------------FKNVDGDKLVMITSRRKPNDEGMCVKPIKKFPTA 362
            :.::.|      :.||.:             |...:|..|:.:....:|  || |.:|
Zfish   118 VDDKEHSTVVLKVQASGLKLYLLVLSAQDYEFAVSEGRDLLSVARSYRP--EG-CSRP------- 172

  Fly   363 SDETKFIFDQFPKARTVQVRKE---GFLGIMVIYGKHAEVGSGIF-ISDLREGSNAELAGVKVGD 423
                          |...:.||   | ||:.:|   ..|...|.: ::.:.:|. ||.||::.||
Zfish   173 --------------RLCHITKEPGCG-LGLSII---PIEGARGRYRLNPVTDGP-AERAGIQNGD 218

  Fly   424 MLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEEKPQE 488
            .|:.:|.......:|.....::|:.|..:|::::               :.:.||.......|..
Zfish   219 RLIWINGVSISVISYAALAKMVKKCEKHLTVLVI---------------DSRSEEIYNRMGLPII 268

  Fly   489 PATAEIK--PNKKILIELKVEKKPMGVIVCGGKNNHVTTGCVITHVYPE------GQVAADKRLK 545
            ||.||..  |.:...:.|....:..|.::   :...:.:| .|.|:..|      .:.|..:..:
Zfish   269 PAFAETHNLPYRPKTLHLTQGPQGYGFLL---RQEKLRSG-RIAHILREIDPCSPAETAGMEDGE 329

  Fly   546 IFDHICDINGTPI----HVG------------SMTTLKV-HQLFHTTYEKAVTLTVFRADP-PEL 592
            |   :..:||..:    |.|            ::||:.: .:.|:|  :.|::..:|..:. |:.
Zfish   330 I---VLAVNGEQVEDAEHEGIVSKIRQSGQQVTLTTISIAGRDFYT--QLAMSPLLFYDEHIPKC 389

  Fly   593 EKFNVDLMK-----------------KAGKELGLSLS--PNEIGCTIADLIQGQYPEIDSKLQRG 638
            |.|....::                 |.|...|.:|.  .|:.|..|..::.|...| .:.|::.
Zfish   390 EPFATPALEHPEGHQNPPQPRLCELHKEGTGFGFNLGCVENKPGTYIGQVVSGSTGE-RAGLRKW 453

  Fly   639 DIITKFNGDALEGLPFQVCYALFKG 663
            |::.:.||..:|...|.....|..|
Zfish   454 DVLIEVNGQNVEDEYFDEVVRLITG 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492	25/106 (24%)
		PDZ_signaling	377..457	CDD:238492	22/83 (27%)
		PDZ_signaling	500..584	CDD:238492	17/106 (16%)
		PDZ_signaling	597..672	CDD:238492	17/86 (20%)
pdzd3a	XP_685398.3	PDZ_signaling	61..142	CDD:238492	22/88 (25%)
		PDZ_signaling	172..252	CDD:238492	23/105 (22%)
		PDZ	280..363	CDD:214570	13/89 (15%)
		PDZ	408..490	CDD:214570	17/72 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900