DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaD and lnx2a

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001106696.2	Gene:	lnx2a / 553331	ZFINID:	ZDB-GENE-060228-2	Length:	737	Species:	Danio rerio

Alignment Length:	516	Identity:	98/516 - (18%)
Similarity:	184/516 - (35%)	Gaps:	154/516 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 DLRRIEVQR-DASKPLGLALAGHKDRQKMACFVAGVDPNGALG-SVDIKPGDEIVEVN----GNV 316
            ::..|||.| :....:|:::.|..:...:...:..|..:|.:. ...:..||:|::||    .||
Zfish   267 EITTIEVHRTNPYSEMGISIVGGNETPLINVVIQEVYRDGVIARDGRLLAGDQILQVNNVDISNV 331

  Fly   317 LKN---------------------RCHLNASAVFKNVDGDKL-VMITSRRKPNDEGMCVKPIKKF 359
            ..|                     ||.....|...:..|... :.||..::.:.|.:.:|.:::
Zfish   332 PHNFARSTLARPCATLQLTVLRERRCSARPPAATASPKGSPASIRITLHKRESSEQLGIKLVRR- 395

  Fly   360 PTASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVGSGIFISDLREGSNAELAG-VKVGD 423
               :||                                   :|:||.||.||..|...| :...|
Zfish   396 ---TDE-----------------------------------AGVFILDLLEGGLAAKDGRLCSND 422

  Fly   424 MLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEEKPQE 488
            .:||||:. .|.....:....:.:|.|....:|::..|::.:.....:...:  :....:..|..
Zfish   423 RVLAVNEH-DLRHGTPELAAQIIQASGERVNLLISRSSKQTMAVHTGSTLTR--DIWSHDHIPPL 484

  Fly   489 PATAEIKPNKKILI------------------ELKVEKKP---MGVIVCGGKNNHVTTG---CVI 529
            |:||...|...:.:                  .:.|:|:|   :|:.|.||:.:  .:|   ..:
Zfish   485 PSTATPSPVPSLHLARSSTQRDLSQCVNCKEKHITVKKEPHESLGMTVAGGRGS--KSGELPIFV 547

  Fly   530 THVYPEGQVAADKRLKIFDHICDINGTPI----HVGSMTTLKVHQLFHTTYEKAVTLTVFRADPP 590
            |.|.|.|.::.|.|:|..|.:..|||..:    |..::.|||......:...||:.:|:  .:.|
Zfish   548 TSVQPHGCLSRDGRIKRGDVLLSINGQDLTYLSHSEAVGTLKSSATSCSVQLKALEVTM--VEEP 610

  Fly   591 ELEKFNVDLMKKAGKELGLSLSPNEI-------------------------GCTIADLIQGQYPE 630
            .|::   :|:.....:...|.||:.:                         |.:|.    |.|.|
Zfish   611 GLDE---ELLPPHENDYDASWSPSWVLWLGLPSYLHSSHEIVLRRSHPGSWGFSIV----GGYEE 668

  Fly   631 -------------------IDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEV 672
                               .|.:|:.||:|...||.:..|:.......:.|....:|::.|
Zfish   669 NHSNQAFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTAGMSHSALVPMLKEQRSRVALTV 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492	20/108 (19%)
		PDZ_signaling	377..457	CDD:238492	17/80 (21%)
		PDZ_signaling	500..584	CDD:238492	25/111 (23%)
		PDZ_signaling	597..672	CDD:238492	19/118 (16%)
lnx2a	NP_001106696.2	zf-RING_2	49..87	CDD:290367
		PDZ	267..353	CDD:214570	16/85 (19%)
		PDZ_signaling	375..455	CDD:238492	23/119 (19%)
		PDZ_signaling	515..600	CDD:238492	23/86 (27%)
		PDZ_signaling	646..730	CDD:238492	16/88 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.960