DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and Grip

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster

Alignment Length:	795	Identity:	154/795 - (19%)
Similarity:	245/795 - (30%)	Gaps:	307/795 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GEVKDSPNT-----KTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDVRNSTEQAVIDLIKEA 106
            |....:|::     ::.|:||..|:|.|.|..||.|.|||::||::
  Fly   306 GSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSID------------------- 351

  Fly   107 DFKIELEIQTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASGGQGMGQGQGQGQGMAGMN 171
            |..||   .|....||.....|..:                          |:|..|.|.|..
  Fly   352 DTMIE---HTAFSPDEVMTILDTST--------------------------GRGYTQMQIMPA-- 385

  Fly   172 RQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYEIDRASAGNCKLNKQEKDRDK 236
              .::.:|..|...|.:...|...............|...::...::..:.|..
  Fly   386 --HALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTP----------- 437

  Fly   237 EQEDEFGYTMAKI-------NKRYNMMKDLRRIE---VQRDASKPLGLALAGHKDRQKMACFVAG 291
                  |.|...:       :....|...|.|.|   |..|.|...|:.|:.         .|:|
  Fly   438 ------GSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSE---------TVSG 487

  Fly   292 VDPNGALGSVDIKP------------GDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMITSRR 344
            ...:||:....|.|            ||.||.:|     ....|:|:|:.:.::|.      |.|
  Fly   488 SGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAIN-----KMYSLDAAAMRQLLEGG------SSR 541

  Fly   345 KPNDEGMCVKPIKKFPTASDETKFIFDQFPKA----------RTVQVRKEGFLGIMVIYGKHAEV 399
            .....|.        |....|.:..|| .|.|          :.::..|.| ||:.|....|
  Fly   542 NGASNGT--------PANWLELEIEFD-MPDAVVPASGVFSVKLLRAGKCG-LGLSVSGSSH--- 593

  Fly   400 GSGIFISDLREGSNAELAG-VKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEE 463
             .|:.|||::.||.|..:| ::.||:||||:|......|.|   .||
  Fly   594 -GGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVD---ALL------------------ 636

  Fly   464 AIKAEKAAEEKKKEEAKKEEEKPQEPA-------TAEIKPNKKILIELKVEKKPMGVIV---CGG 518
                             |||.:.|.|:       |..|   |:|::.   :..||...:   |..
  Fly   637 -----------------KEEGRSQNPSHSSSDFTTLTI---KRIVLP---DFLPMSSPIYSNCPA 678

  Fly   519 KNNHVTTGCVIT-----HVYPEGQVAADK-----------------RLKIFDHI----------C 551
            ...::..|..::     .:|....|.|.|                 |:...|..          .
  Fly   679 SGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGS 743

  Fly   552 DING------------------TPIHVGSMTT-----LKVHQLFHTTYE----KAVTLTVFRADP 589
            ..||                  .|.:..|:||     ....:..:..||    .:|..|   |.|
  Fly   744 GSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCT---ALP 805

  Fly   590 PELEK----------------------FNVDLMKKAGKELGLSLSPNE---IGCTIADLIQGQYP 629
            |.:|.                      |.|.|..|.|. ||::|:.:|   ...||:.|::|...
  Fly   806 PPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGL-LGITLAGSEDITKSITISGLVEGGIA 869

  Fly   630 EIDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEV---------------------- 672
            ..:.::..||.:...:..:::|:|.....:|.:.....|.:::
  Fly   870 HKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKV 934

  Fly   673 -TRPK-PTLRTEAPK 685
             .||: |:..|||.|
  Fly   935 QRRPRSPSANTEASK 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	20/72 (28%)
		PDZ_signaling	259..340	CDD:238492	23/95 (24%)
		PDZ_signaling	377..457	CDD:238492	25/80 (31%)
		PDZ_signaling	500..584	CDD:238492	20/145 (14%)
		PDZ_signaling	597..672	CDD:238492	18/77 (23%)
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492
		PDZ_signaling	278..375	CDD:238492	24/116 (21%)
		PDZ	496..>521	CDD:294084	6/24 (25%)
		PDZ_signaling	571..658	CDD:238492	32/132 (24%)
		PDZ_signaling	832..913	CDD:238492	19/81 (23%)
		PDZ_signaling	973..1055	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900