DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and CG15803

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	102/553 - (18%)
Similarity:	180/553 - (32%)	Gaps:	167/553 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DSPNTKT--------------------------TGIFIKGIVPDSPAHLCGRLKVGDRILSLNGK 89
            |||.|:|                          :|||:|.|:..|.|...|::::.|||::::|:
  Fly   302 DSPETETYVVELHKNVYGLGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGR 366

  Fly    90 DVRNSTEQAVIDLIKEADFKIELEIQTFDKSDE--------QQAKSDPRSNGYMQAKNKFNQEQT 146
            .:...|....::|::..|..:.|.::.|.:..:        .:.|.....:|..::::| :|:|.
  Fly   367 SLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDK-DQDQE 430

  Fly   147 TNNNASGG---------------------QGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASM--- 187
            :..:..|.                     :|......:..|::|...:........|..::|
  Fly   431 SQLSMPGSPSIATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHV 495

  Fly   188 --RQKHSN-----------------------YADEDDEDTRDMTGRIRTEAGY-------EIDRA 220
              |..||.                       .||:...||.:......||...       |.:|.
  Fly   496 LDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERV 560

  Fly   221 SAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGHKDRQKM 285
            .    .|...:.|.|.:.:.:.|......|:............: |.|.|.||::|.|..|   :
  Fly   561 K----DLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASL-RVAWKSLGISLEGTVD---V 617

  Fly   286 AC--------FVAGVDPNGALGSVDI-KPGDEIVEVNGNVLKNRCHLNASAVFKNVDGD-KLVMI 340
            .|        ::..:..:|.:|...| :||||:::||.:.|:...|:....:.|.:... |||..
  Fly   618 ECGIEKRPHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCA 682

  Fly   341 TSRRKPNDEGMCVKPIKKFPTAS------------------------DETKFIFDQFPKA----- 376
            .....|:.......| :.|.|.|                        ..|..:.|....|
  Fly   683 RGTHVPSVINTSQNP-EAFETRSLLPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGG 746

  Fly   377 ------------------------RTVQVRK--EGF-LGIMVIYGKHAEVGSGIFISDLREGSNA 414
                                    ..|.:.|  :|| ..|:.........||.|.|..|..|..|
  Fly   747 TAGGGARSKSLENVSGLALWSCEVTAVDIEKTEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAA 811

  Fly   415 ELAG-VKVGDMLLAVNQDVTLESNYDDATGLLK 446
            |... :..||.|::|...:......|:|..:||
  Fly   812 EATNEIYPGDRLMSVGDRLLQGLELDEAVSILK 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	21/89 (24%)
		PDZ_signaling	259..340	CDD:238492	24/90 (27%)
		PDZ_signaling	377..457	CDD:238492	21/74 (28%)
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492
		PDZ	307..393	CDD:214570	17/85 (20%)
		PDZ_signaling	605..680	CDD:238492	20/77 (26%)
		PDZ	773..858	CDD:214570	21/72 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	P	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.810