DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment inaD and GRID2IP

DIOPT Version :9

Sequence 1:NP_001246470.1 Gene:inaD / 37629 FlyBaseID:FBgn0001263 Length:686 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:721 Identity:136/721 - (18%)
Similarity:226/721 - (31%) Gaps:258/721 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 FIKGIVPDSPAHLCGRLKVGDRILSLNGKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQA 125
            |:..:...|.|| .|.|:.||:||.:.|..|...:.:.::.|.:                   :.
Human    28 FVLEVAKGSSAH-AGGLRPGDQILEVEGLAVGGLSRERLVRLAR-------------------RC 72

  Fly   126 KSDPRSNGYMQAKNKFNQEQTTNNNASGGQGMGQGQGQ----------GQGMAGMNRQ---QSMQ 177
            ...|.|.|.:.|.:             ||.|.|.|...          |:|:| :.|:   .:.:
Human    73 PRVPPSLGVLPAPD-------------GGPGPGSGPAAPTTVLRAPRCGRGLA-LGRELLRLAGR 123

  Fly   178 KRNTTFTASMRQKHSNYADEDDEDTRDM-TGRIRTEAGYEIDRASAGNCKLNKQEKDRDKEQEDE 241
            ||........|:|...::.:.||...|. |.:.:..|..:...|               :::.|:
Human   124 KRPDAVHRERRRKAQEFSRKVDEILGDQPTAKEQVFAALKQFAA---------------EQRVDD 173

  Fly   242 FGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGHKDRQKMACFVAGVDPNGALGSVDIKPG 306
            ..:|:.              :.:.|:|..||...|.....::..|.|                  
Human   174 LVWTLT--------------LALPREACGPLLDNLRIFIPKKHRARF------------------ 206

  Fly   307 DEIVE--VNGNVLKNRCHLNASAVFKNVD---GDKLVMITSRRKPNDEGMCVKPIKKFPTASDET 366
            ||:|.  :.|.:.:.|....|..:.::..   .::|::.|....|             |...|| 
Human   207 DEVVSQGLLGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAP-------------PRRPDE- 257

  Fly   367 KFIFDQFPKARTVQVRKEGFLG------IMVIYGKHAEVG------SGIFISDLREGSNAELAGV 419
                   |..|...:...|..|      .:.:|..:...|      ..::|..:..||.|:.|.:
Human   258 -------PPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAAL 315

  Fly   420 KVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEE 484
            |.||.:|.:|.......::|....:|:.:..:.|:::           |:.......:....:..
Human   316 KSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVV-----------EEGLVPFASDSDSLDSP 369

  Fly   485 KPQEPAT-----AEIKPNKKILIELKVEKK------------PMGVIVCGGKNN---HVTTGCVI 529
            .|....|     |||.|:     .::|:.:            |....||....:   |.....:|
Human   370 NPSSALTSLQWVAEILPS-----SIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLI 429

  Fly   530 THVYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKA----------VTLTV 584
            ..|||.....|.:.|..|                    ::||.  |||:.          :..|.
Human   430 VDVYPVLDTPAKQVLWQF--------------------IYQLL--TYEEQELCQEKIACFLGYTA 472

  Fly   585 FRADP-PELEKFNVDL-----------------------MKKAGKELGLSLSPNEIGCTIADLIQ 625
            ..|:| |||     ||                       ::..|.|.|||..|:|  |....|  
Human   473 MTAEPEPEL-----DLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSE--CPEMPL-- 528

  Fly   626 GQYPEIDSKLQRGDIITKFNGDALEGLP----FQVCYA--------LFKGANGKVSMEVTR---P 675
               |.|..:.|.||      |.:|...|    ....||        .|||..|.||.....   |
Human   529 ---PLIPGERQAGD------GTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGP 584

  Fly   676 KPTLRT 681
            .|.:.|
Human   585 SPAVTT 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
inaDNP_001246470.1 PDZ_signaling 27..115 CDD:238492 13/53 (25%)
PDZ_signaling 259..340 CDD:238492 14/85 (16%)
PDZ_signaling 377..457 CDD:238492 18/91 (20%)
PDZ_signaling 500..584 CDD:238492 17/108 (16%)
PDZ_signaling 597..672 CDD:238492 27/109 (25%)
GRID2IPNP_001138590.1 PDZ_signaling 14..74 CDD:238492 13/65 (20%)
HN_L-delphilin-R1_like 133..212 CDD:259820 20/125 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269 9/63 (14%)
PDZ_signaling 278..353 CDD:238492 15/85 (18%)
HN_L-delphilin-R2_like 389..468 CDD:259821 17/100 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600 8/23 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783
FH2 820..1188 CDD:280362
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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