DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and patj

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_005161760.1	Gene:	patj / 368723	ZFINID:	ZDB-GENE-030616-129	Length:	1914	Species:	Danio rerio

Alignment Length:	745	Identity:	189/745 - (25%)
Similarity:	292/745 - (39%)	Gaps:	224/745 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KKSFGICIVRG-----EVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDVRNSTE 96
            ::|.||.||.|     .:|:....|  |||||.::.||||...|.||.||:||.::|.|::|::.
Zfish  1063 EESLGISIVGGRTVIKRLKNGEELK--GIFIKQVLADSPAGRTGALKTGDKILQVSGVDLQNASH 1125

  Fly    97 QAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPR-----SNGYMQAKNKFNQEQTTNNNASGGQG 156
            :..:..||.|...:...:|:.        .|.||     ::...|.|.|              :.
Zfish  1126 EEAVQTIKAAPSPVVFIVQSL--------SSTPRPVSVTASSIKQHKAK--------------RK 1168

  Fly   157 MGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYEIDRAS 221
            ..|..|||.....|......:..:..
Zfish  1169 AAQKAGQGAAPPPMRLPPPYRPPSQV--------------------------------------- 1194

  Fly   222 AGNCKLNKQEKDRDKEQEDEFGYTMAKINKRY-NMMKDLRRIEVQRDASKPLGLALAGHKDRQKM 285
                    ||::.::|:|||  .....|.:|| ::..:|..:|:::|.: .|||:|||::||..|
Zfish  1195 --------QEEEHEQEEEDE--QDTEVIRQRYADLPGELLIVELEKDRN-GLGLSLAGNRDRSCM 1248

  Fly   286 ACFVAGVDPNGALGSVD--IKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGD-KLVMITSRRKPN 347
            :.||.|:...|. .|.|  ||.|||::|:|..||..|.|.||||:.|:.... |||::.:....|
Zfish  1249 SIFVVGITTGGP-ASRDGRIKVGDELLEINSQVLYGRSHQNASAIIKSAASKVKLVLVRNEDAIN 1312

  Fly   348 DEGMCVKPIKKFPT--ASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVGSGIFISDLRE 410
            .  |.|.|....|.  :|.||    .:.|.|               :..:..::...:.:|  |.
Zfish  1313 Q--MAVTPFPSQPALFSSSET----HENPPA---------------VPAEKPQLPESLPLS--RS 1354

  Fly   411 GSNAELAGVKVGDMLLAVNQD---VTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAE 472
            .....|            |:|   ||..::.|.....|...|..|         ::...|||..|
Zfish  1355 PPENTL------------NKDQACVTATASSDPTHKSLTDGESAV---------KKLKPAEKLLE 1398

  Fly   473 EKKKEEAKKEEE-------------KP---------------------------QEPATAEIKPN 497
            ...::.||.:.|             ||                           ::|||..|.|.
Zfish  1399 SPSEQSAKPQVEQIPSLPKLQRSSTKPSAGSLEVTSSASSVPVSGTSPDFEYCSKDPATCPIVPG 1463

  Fly   498 KKILIELKVEKKPMGVIVCGGKNNHVTTGCVITHVYPEGQVAADKRLKIFDHICDINGTPI---- 558
            ::.:||:...:..:|:.:.|||:..: ...||..||.||..|.|.||...|.|.::||..:
Zfish  1464 QETVIEISKGRSGLGLSIVGGKDTQL-DAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRSVA 1527

  Fly   559 HVGSMTTLKVHQLFHTTYEKAVTLTVFR-----ADPPELEKFNVDLMKKAGKELGLSL--SPNEI 616
            |..::..|:      .|..| |.|||.|     .|...|:.|.|:|.||.|:.||||:  ..|..
Zfish  1528 HEDAIAALR------QTPPK-VRLTVLRDEAQYRDEENLDVFPVELQKKTGRGLGLSIVGKRNGK 1585

  Fly   617 GCTIADLIQGQYPEIDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEVTR------- 674
            |..|:|:::|...::|.:|.:||.|...:|:.:.....:...|:.|.|.|||.:|:.|
Zfish  1586 GVFISDVVKGGAADLDGRLMQGDQILSVDGEDMRQASQETVAAILKCARGKVLLELGRLKAASWI 1650

  Fly   675 --------------------PKPTLRTEAP 684
                                |.||..|.||
Zfish  1651 SSRRTSQGSQMSHASGSSSTPTPTPPTVAP 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	30/82 (37%)
		PDZ_signaling	259..340	CDD:238492	37/83 (45%)
		PDZ_signaling	377..457	CDD:238492	11/82 (13%)
		PDZ_signaling	500..584	CDD:238492	26/87 (30%)
		PDZ_signaling	597..672	CDD:238492	26/76 (34%)
patj	XP_005161760.1	L27_2	12..69	CDD:117611
		PDZ_signaling	131..>191	CDD:238492
		PDZ_signaling	238..317	CDD:238492
		PDZ	361..449	CDD:214570
		PDZ_signaling	563..627	CDD:238492
		PDZ_signaling	731..817	CDD:238492
		PDZ_signaling	1053..1144	CDD:238492	30/82 (37%)
		PDZ	1222..1307	CDD:214570	37/86 (43%)
		MPDZ_u10	1398..1463	CDD:293272	10/64 (16%)
		PDZ	1464..1549	CDD:214570	28/92 (30%)
		PDZ_signaling	1561..1641	CDD:238492	27/79 (34%)
		PDZ_signaling	1707..1792	CDD:238492
		PDZ_signaling	1829..1913	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10810
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920