Protein Alignment inaD and IL16

DIOPT Version :9

• Sequence 1: NP_001246470.1
• Gene: inaD / 37629
• FlyBaseID: FBgn0001263
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001339615.1
• Gene: IL16 / 3603
• HGNCID: 5980
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 119/584 - (20%)
• Similarity: 216/584 - (36%)
• Gaps: 152/584 - (26%)

  Fly   172 RQQSMQKRNTTFTASMR-QKHSNYADEDDEDTRDMTGRIRTEAGY-EIDRA-SAGNCKLNKQEKD 233
            |.:..:::..:||:|:| :.||.            .|:.|..|.: .|.|: ...|.|.:.....
Human    35 RARDQERKKGSFTSSLRMESHSR------------AGKSRKSAKFRSISRSLMLCNAKTSDDGSS 87

  Fly   234 RDKEQEDEFGYTMAKINKR-YNMMKDLRRIEVQRDASKPLGLALAGH--------KDRQKMACFV 289
            .|::..|.|..::|:..:. ::....|........:|.| .||||..        .||.|....:
Human    88 PDEKYPDPFEISLAQGKEGIFHSSVQLADTSEAGPSSVP-DLALASEAAQLQAAGNDRGKTCRRI 151

  Fly   290 AGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNV--------------------DG 334
            ..:..:....|.: |||....:.:..:....||..|.:...:|                    |.
Human   152 FFMKESSTASSRE-KPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDR 215

  Fly   335 DKLVMITSRRKPNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQ-------------VRKEG- 385
            ....:.::|:..:.:..|  |..|....|..|:    ....|:.||             |..:|
Human   216 QPYSLCSNRKSLSQQLDC--PAGKAAGTSRPTR----SLSTAQLVQPSGGLQASVISNIVLMKGQ 274

  Fly   386 --FLGIMVIYGKHAEVGS-GIFISDLREGSNAELAG-VKVGDMLLAVNQDVTLESNYDDATGLLK 446
              .||..::.||.:..|. ||::..:..|..|...| ::.||.:|.:|.:......:.||....|
Human   275 AKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFK 339

  Fly   447 RA-EGVVTMILLT-------------------LKSEEAIKAEKAAEEKKKEEAKKEEEKPQEP-A 490
            :| :|::|:.:.|                   |.|...|         .|:.:....|.|..| :
Human   340 QAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCI---------TKDSSSFALESPSAPIS 395

  Fly   491 TAEIKPNKKILIELKVEKKP---MGVIVCGGKNNHVTTGCVITHVYPEGQVA-ADKRLKIFDHIC 551
            ||  |||.:|::|:.::|:.   :|:.:|........:| :..|....|.|| .|.||:..|.|.
Human   396 TA--KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG-IFVHTLSPGSVAHLDGRLRCGDEIV 457

  Fly   552 DINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFRADPPELEKFNVDLMKKAGKELGLSLSPNEI 616
            :|:.:|:|  .:|..:|:.:........|.:.|.|...|::.:   ..:|:|
Human   458 EISDSPVH--CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE---QQLKEA------------- 504

  Fly   617 GCTIADLIQGQYPEIDSKLQRGDIITKFNGD----ALEGLPFQVCYALFKGANGKVSMEVTRPK 676
               :|..::.               |||..:    :|||:.     .|....:|:.::|..|.|
Human   505 ---VAQAVEN---------------TKFGKERHQWSLEGVK-----RLESSWHGRPTLEKEREK 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492	19/108 (18%)
		PDZ_signaling	377..457	CDD:238492	24/98 (24%)
		PDZ_signaling	500..584	CDD:238492	21/87 (24%)
		PDZ_signaling	597..672	CDD:238492	11/78 (14%)
IL16	NP_001339615.1	PDZ_signaling	268..351	CDD:238492	22/82 (27%)
		PDZ_signaling	406..488	CDD:238492	20/84 (24%)
		COG1615	<911..1006	CDD:332639
		PDZ_signaling	1162..1239	CDD:238492
		PDZ	1284..1370	CDD:214570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910