DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and Dlg5

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	121/637 - (18%)
Similarity:	230/637 - (36%)	Gaps:	157/637 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 ELEIQTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASGGQGMGQGQGQGQGMAGMNR--- 172
            :|.:.:....:|:.::.....|......|  :...||..|.|...|..:|...|.|::|::.
  Fly     8 DLSLTSTSSQEEESSEYVGYDNTLRPPSN--SSGSTTAANMSNNNGPSKGVSSGVGVSGISGGNG 70

  Fly   173 -----QQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYEIDR--------ASAGN 224
                 .|:..|.......::|.:|:|.....||...::|   ..:..|..||        .||..
  Fly    71 ANYDILQAQYKSALLELNTLRHQHANTKRRCDELATELT---LYQEHYVADRNKFTDMVEESARF 132

  Fly   225 CKLNKQEKDRDKEQEDE---------------FGYT----------MAKINKRYNMMKDLRRIEV 264
            .:|..:.:::..:|...               ||.|          :|::.|..||      :.|
  Fly   133 KRLLLETQNQQSQQAQNGNSQVPPVGSGNPYYFGKTQGCDGSCSEKLAELKKERNM------VAV 191

  Fly   265 QRDASKPLGLALAGHKDR----------QKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKN 319
            :|:..|...:.|  .|||          ||:...::....|....:.::   ::::....|||:.
  Fly   192 EREKYKKSYIEL--EKDRNYYRERGDENQKLKVLLSQESKNVLSLTEEL---NQLLSEKDNVLQE 251

  Fly   320 RCHLNASAVFKNVDGDKLVMITSRRKPNDEGMCVKPIKKFPTASDETK----------FIFDQFP 374
            ...::...|..|.:.::|        ..||.:....||....|:.:.|          ....:||
  Fly   252 HQKMSDDLVLANKEIERL--------KKDEQLARAEIKVLQLANADLKKRDLLKSRDSSWSKEFP 308

  Fly   375 KARTVQVRKEGFLGIMVIYGKHAEVGSGIFISDLREGSNAELAGVKVGDMLLAVNQDVTLESNYD 439
            ..:.::..||     :....|..|..    :|::...|.......:|.|.  |::|...:....|
  Fly   309 SGKELENSKE-----LEKLRKSLEKA----LSEVERSSQDAEEAKRVRDW--AISQREKIVQERD 362

  Fly   440 DATGLLKR----AEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEEKPQEPATAE------- 493
            ....|..:    .:..::..|:.::..|.||.:| .|.:||.:..||:.:.||....:
  Fly   363 SVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQK-DEAQKKIDLLKEQMEQQERQNLDSNASGSR 426

  Fly   494 --IKPNK---KILIELKV----EKKPMGVIVCGGKNNHVTTGCVITHVYPEGQVAADKRLKIFDH 549
              .:|:.   :.|:|:::    ....:|:|:  ..:|.....|.:|...|     |..:|||.|.
  Fly   427 RSFRPSSYEGEDLLEVELSGYEHTSDLGIIL--DDSNKRKLVCGVTSSSP-----ACGKLKINDV 484

  Fly   550 ICDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFRADPP------------ELEKFNVDLMKK 602
            ||               ||:.|...:..|.:.|...||..|            :...::|.| |.
  Fly   485 IC---------------KVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHSKRHAYSVQL-KT 533

  Fly   603 AGKEL--GLSLSPNEIGCTIADLIQGQYPEIDSKLQRGDIITKFNGDALEGL 652
            ..::.  ||.|   ::|..||.:.|......:.:|..||.:...|..:::.:
  Fly   534 RDRDCPHGLQL---DMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSV 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	1/3 (33%)
		PDZ_signaling	259..340	CDD:238492	16/90 (18%)
		PDZ_signaling	377..457	CDD:238492	12/83 (14%)
		PDZ_signaling	500..584	CDD:238492	20/87 (23%)
		PDZ_signaling	597..672	CDD:238492	14/58 (24%)
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	36/195 (18%)
		CENP-F_leu_zip	229..360	CDD:287450	25/152 (16%)
		DUF1090	<326..408	CDD:284007	17/88 (19%)
		PDZ_signaling	439..516	CDD:238492	23/98 (23%)
		PDZ_signaling	533..592	CDD:238492	11/53 (21%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900