DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaD and slc9a3r1a

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_997872.2	Gene:	slc9a3r1a / 327272	ZFINID:	ZDB-GENE-031006-7	Length:	384	Species:	Danio rerio

Alignment Length:	363	Identity:	75/363 - (20%)
Similarity:	133/363 - (36%)	Gaps:	101/363 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MVTLDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDVRN 93
            :..|:| |...:|..: .|| |:.|     |.||:.:.|||||...| |..||::..:||::|.:
Zfish     9 LCVLEK-GDTGYGFHL-HGE-KNKP-----GQFIRHVEPDSPAAAAG-LLAGDKLALVNGENVED 64

  Fly    94 STEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASGGQGMG 158
            ...|.|:..|::...|:||.:...:.::.           .::...|..:|..|:
Zfish    65 EKHQQVVSRIRDTVGKLELVVLNAETAEL-----------LLKHNLKCQKEYVTD---------- 108

  Fly   159 QGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYEIDRASAG 223
                 |..:...:..:...|..|:                   :|:.|....|.....|||.|..
Zfish   109 -----GIPIPAGSEPEDEVKNGTS-------------------SRESTPVPETNGDMRIDRLSVS 149

  Fly   224 NCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGHKDRQKMACF 288
            :           |:.::|....:..|.|                .:...|..|  |.::.|...:
Zfish   150 S-----------KDSKNELRPRLCHIKK----------------GATGYGFNL--HTEKTKPGQY 185

  Fly   289 VAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGD--KLVMITSRRK------ 345
            :..||.:.......::|.|:||:|||..:....|....|..| ..||  ||:::.....
Zfish   186 IRAVDEDSPAEKSGLRPQDKIVQVNGISVHTMQHSEVVAAIK-AGGDETKLLVVDPEADAFFMSC 249

  Fly   346 ---PNDE---GMCVKPIKKFPTASDET--KFIFDQFPK 375
               |.:|   |...:||.: ..|.::.  |.:.::.||
Zfish   250 EILPTEEHLTGPLPEPIPR-REAEEQVNGKVVQEEKPK 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	29/85 (34%)
		PDZ_signaling	259..340	CDD:238492	20/82 (24%)
		PDZ_signaling	377..457	CDD:238492
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
slc9a3r1a	NP_997872.2	PDZ_signaling	7..86	CDD:238492	29/85 (34%)
		PDZ_signaling	159..238	CDD:238492	22/97 (23%)
		EBP50_C	242..384	CDD:312529	9/46 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900