DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and Slc9a3r1

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_036160.1	Gene:	Slc9a3r1 / 26941	MGIID:	1349482	Length:	355	Species:	Mus musculus

Alignment Length:	476	Identity:	96/476 - (20%)
Similarity:	159/476 - (33%)	Gaps:	149/476 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PFPELIHMVTLDKTGKKSFGICI--VRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRIL 84
            |.|.|   ..|:| |...:|..:  .:|:|         |.||:.:.|.|||...| |..|||::
Mouse    10 PLPRL---CCLEK-GPNGYGFHLHGEKGKV---------GQFIRLVEPGSPAEKSG-LLAGDRLV 60

  Fly    85 SLNGKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNN 149
            .:||::|...|.|.|:..|:.|...:.|.:            .||.::
Mouse    61 EVNGENVEKETHQQVVSRIRAALNAVRLLV------------VDPETD----------------- 96

  Fly   150 NASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAG 214
                                        :|......|:|::.....::.::          .|..
Mouse    97 ----------------------------ERLKKLGVSIREELLRPQEKSEQ----------AEPP 123

  Fly   215 YEIDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGH 279
            ...|...||:  .|:.||...:|           :..|...||           ..|.|.....|
Mouse   124 AAADTHEAGD--QNEAEKSHLRE-----------LRPRLCTMK-----------KGPNGYGFNLH 164

  Fly   280 KDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLN-ASAVFKNVDGDKLVMITSR 343
            .|:.|...|:..|||:....:..::..|.||||||..::.:.|.: .||:....|..||:::.
Mouse   165 SDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKGGGDEAKLLVVD-- 227

  Fly   344 RKPNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVGSGIFISDL 408
             |..||  ..|..|..|:.......:.:.|...   :::||.        .:.|      .:...
Mouse   228 -KETDE--FFKKCKVIPSQEHLDGPLPEPFSNG---EIQKES--------SREA------LVEPA 272

  Fly   409 REGSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMI-----LLTLKSEEAIKAE 468
            .|.....||        .:.:.|.:.|.|..|:.......|...|..     :|.|....|:..|
Mouse   273 SESPRPALA--------RSASSDTSEELNSQDSPKRQVSTEPSSTSSSSSDPILDLNISLAVAKE 329

  Fly   469 KAAEEKKKEEA------KKEE 483
            :|.:::..:.|      ||.|
Mouse   330 RAHQKRSSKRAPQMDWSKKNE 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	27/89 (30%)
		PDZ_signaling	259..340	CDD:238492	22/81 (27%)
		PDZ_signaling	377..457	CDD:238492	12/84 (14%)
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
Slc9a3r1	NP_036160.1	PDZ_signaling	12..91	CDD:238492	29/104 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..146		8/58 (14%)
		PDZ_signaling	147..226	CDD:238492	25/89 (28%)
		EBP50_C	230..355	CDD:286142	27/148 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..355		22/132 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900