Protein Alignment inaD and Frmpd2

DIOPT Version :10

• Sequence 1: NP_001246470.1
• Gene: inaD / 37629
• FlyBaseID: FBgn0001263
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001423165.1
• Gene: Frmpd2 / 268729
• MGIID: 2685472
• Length: 1383
• Species: Mus musculus
• Alignment Length: 764
• Identity: 174/764 - (22%)
• Similarity: 267/764 - (34%)
• Gaps: 243/764 - (31%)

  Fly    24 PE---LIHMVTLDK---TGKKSFGIC---IVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKV 79
            ||   |:|.|:.:|   .||.:.|:|   |:..||:.|....|:         ..|....|.:..
Mouse   531 PEYGVLVHRVSPEKKRPEGKMALGVCTKGIIVYEVRGSRRIATS---------QFPWRETGMIST 586

  Fly    80 GDRIL----SLNGKD---VRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQA 137
            ..:.|    |..||.   |.||::.....|                              |...:
Mouse   587 HRKKLTITSSTTGKKYTFVTNSSKTCKYLL------------------------------GLCSS 621

  Fly   138 KNKFNQEQTTNNNASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDD--- 199
            ::.|| .||.:.:.|   ....||.:...:|.::.....|....|:.    ||.|  ..|::
Mouse   622 QHWFN-AQTGSKHPS---HRFTGQDKFAQIASLSSAHQTQANPITWI----QKLS--CSENELCV 676

  Fly   200 EDTRDMTGRIRTEAGYEIDRASAGNCKLNKQE-KDRDKEQEDEFGYTMAKINKRYNMMKDLRRIE 263
            ...:|.||            ...|....|||. |:..||:.....||..         :.|..|.
Mouse   677 PRLQDATG------------GQLGTSMENKQGFKEPGKERIGSSPYTGG---------EQLHSIG 720

  Fly   264 V-QRDASKPLGLALAGHKDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASA 327
            : |:.|....|  .|||.       ..||                      .|.|..|..:   .
Mouse   721 LNQKPAQTVFG--TAGHS-------MCAG----------------------SNCLGRRTQI---C 751

  Fly   328 VFKNVDGDKLVMITSRRK-----PNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKEGFL 387
            .|.:|.|.:    .|:||     ||.:.:||. :|:.|.                      .||
Mouse   752 CFDSVSGSQ----NSKRKGLFGEPNQDIVCVM-LKRDPV----------------------HGF- 788

  Fly   388 GIMVIYGKHAE-VGSGIFISDLREGSNAELA-GVKVGDMLLAVNQDVTLE------------SNY 438
            |.::..|:.|| ..||||||.|..|..||.| .:|.|..:||:|. ::||            ::.
Mouse   789 GFVINEGEDAEQTRSGIFISSLIPGGPAERAKKIKPGGKILALNH-ISLEGFTFSMAVRMIQNSP 852

  Fly   439 DDATGLLKRAEGVVTMILLTLKSEE-----------------AIKAEKAAEEKKKEEAKKEEEKP 486
            ||...::.:.:||..    |:.|||                 ..:..::.....::.:.:..|..
Mouse   853 DDMELIISQPKGVCG----TIHSEEKNSTASSGMFCTDILSNRCQGRQSPHIHDQDRSVRGTEMA 913

  Fly   487 Q-----EPATAEIKPNKKILIELKVEKKPMGVIVCGGKNNHVTTGCV-ITHVYPEGQVAADKRLK 545
            |     .|:..:....:...:||..|...:|..|.||.|..|..|.: :..:.|.|..|.:.::.
Mouse   914 QGAGSCPPSPLQTNTGEIYFVELVKEDGTLGFSVTGGINTSVPHGGIYVKSIIPGGPAAKEGQIL 978

  Fly   546 IFDHICDINGTPI----HVGSMTTLK-VHQLFHTTYEK---------------------AVTLTV 584
            ..|.:..::|..:    |..::..|| ..|:.....|:                     ||:|..
Mouse   979 QGDRLLQVDGVSLCGLTHKQAVQCLKGPGQVARLVLERRGPRAAPQCPSADDRMGDVHMAVSLVT 1043

  Fly   585 FRADPP-------ELEKFNVDLMKKAGKELGLSLSPNEIG-C--TIADLIQ------GQYPEIDS 633
            .|...|       :..||.|.| ||..:.||.|....|.| |  |.:||::      ||..|...
Mouse  1044 ARPGRPASSVSVTDGPKFEVKL-KKNSRGLGFSFVQMERGNCIHTKSDLVRIKRLFPGQPAEEHG 1107

  Fly   634 KLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEVTRPKPTLRTE 682
            .:..||||...||..:|||.||....|.:||..:|::.:.||.|.:..|
Mouse  1108 AIAAGDIILAVNGKPIEGLAFQEVLHLLRGAPEEVTLLLCRPPPGILPE 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ1_INAD-like	29..115	CDD:467276	21/98 (21%)
		PDZ8_MUPP1-PDZ7_PATJ-PDZ2_INAD-like	259..342	CDD:467160	16/83 (19%)
		PDZ3_INAD-like	379..454	CDD:467277	28/88 (32%)
		PDZ4_INAD-like	501..585	CDD:467278	23/110 (21%)
		PDZ5_INAD-like	596..674	CDD:467279	31/86 (36%)
Frmpd2	NP_001423165.1	Protein Kinases, catalytic domain	6..188	CDD:473864
		Ubl1_cv_Nsp3_N-like	329..422	CDD:475130
		B41	334..538	CDD:214604	3/6 (50%)
		PH-like	534..635	CDD:473070	28/140 (20%)
		PDZ_canonical	774..865	CDD:483948	30/115 (26%)
		PDZ2-PTPN13_FRMPD2-like	930..1016	CDD:467254	19/85 (22%)
		PDZ3_PTPN13_FRMPD2-like	1061..1149	CDD:467181	32/88 (36%)