DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaD and Cytip

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_631939.1	Gene:	Cytip / 227929	MGIID:	2183535	Length:	359	Species:	Mus musculus

Alignment Length:	384	Identity:	77/384 - (20%)
Similarity:	127/384 - (33%)	Gaps:	145/384 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MVTLDKTGKKSFGICIVRGEVKDSPNTKTTGI--FIKGIVPDSPAHLCGRLKVGDRILSLNGKDV 91
            :||::|....:||..|....:::. |..::.:  .|..:..||||| |..|:|||...::||...
Mouse    77 VVTVEKQDNGTFGFEIQTYRLQNQ-NICSSEVCTMICKVQEDSPAH-CAGLQVGDIFANVNGVST 139

  Fly    92 RNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASGGQG 156
            ...|.:.|:|||:.:...:.:|                ..||.|
Mouse   140 EGFTHKQVVDLIRSSGNLLTIE----------------TLNGTM--------------------- 167

  Fly   157 MGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQK---------------HSNYADED-----DED 201
                         ::|:..::.:..|...::::|               |.:.|:..     |.|
Mouse   168 -------------IHRRAELEAKLQTLKQTLKKKWVELRSLHLQEQRLLHGDTANSPNLENMDLD 219

  Fly   202 TRDMTGRIRTEAGYEIDR---ASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIE 263
            ...:.|.:...:...:||   :|..:||........|.|.    ||       |.:|.:|..|..
Mouse   220 ESSLFGNLLGPSPALLDRHRLSSESSCKSWLSSLTVDSED----GY-------RSSMSEDSIRGA 273

  Fly   264 VQRDASKPLGLALAGHKDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRC------- 321
            ..|..|          .|.:   ||.:             |.||||:. |.:..:||.
Mouse   274 FSRQTS----------TDDE---CFHS-------------KDGDEILR-NASSRRNRSISVTSSG 311

  Fly   322 ------HLNASAVFKNVDGDKLVMITSRRKPNDEGMCVKPIKKF------PTASDETKF 368
                  ..|.|:||..:..      .|||     |...|.|.||      ....:|::|
Mouse   312 SFSPLWESNYSSVFGTLPR------KSRR-----GSVRKQILKFIPGLHRAVEEEESRF 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	26/87 (30%)
		PDZ_signaling	259..340	CDD:238492	18/93 (19%)
		PDZ_signaling	377..457	CDD:238492
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
Cytip	NP_631939.1	PDZ_signaling	76..161	CDD:238492	25/85 (29%)
Cytip	NP_631939.1	Interaction with CYTH1. /evidence=ECO:0000250	166..188		3/55 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900