DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and magi-1

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001255577.1	Gene:	magi-1 / 178107	WormBaseID:	WBGene00010444	Length:	1054	Species:	Caenorhabditis elegans

Alignment Length:	604	Identity:	126/604 - (20%)
Similarity:	230/604 - (38%)	Gaps:	132/604 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IHMVTLDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDV 91
            :|.:.:.| |.:.||..|.     |:.|    |..||.|:..|.   |..|..||.|:.|:|::|
Worm   535 LHEIDIFK-GSEGFGFTIA-----DNLN----GQRIKKILFPSQ---CPNLMEGDTIVELDGRNV 586

  Fly    92 RNSTEQAVIDLIKE--ADFKIELEIQTFDKSDEQQAKSDPRSNGYM-QAKNKFNQEQTTNNNASG 153
            |......::|:::|  ..::.:|.::          :..|::.... .|..::.:.||...:::.
Worm   587 RPIPHTQLVDMLRERPIGYRGKLVVK----------RGSPKTRSRTPSAAFRYGEPQTNMMDSAA 641

  Fly   154 GQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYEID 218
            ...:              |.::..:|.|:.|            |:|::.|:...|..........
Worm   642 PLPV--------------RSKTPAERQTSRT------------EEDQNVRNTLQRQPAVTSEWEG 680

  Fly   219 RASAGNCKLNKQEKDRDKEQEDEFGYTMAKIN----KRYNMM-KDLRRIEVQRDASKPLGLA--- 275
            .:||       ....|.:......|:  |..|    .:||.. .||..:.:.|   ||:|..
Worm   681 MSSA-------IPASRMRPSSTTLGF--ATPNYIPLSQYNQKPSDLITVSLIR---KPVGFGFRL 733

  Fly   276 LAGHKDRQKMAC--FVAG--VDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDK 336
            |.|.:.:..::.  .|.|  .:.:|.|     :.||||||::|:.::...|..|..:.:....:|
Worm   734 LGGVESKTPLSVGQIVIGGAAEEDGRL-----QEGDEIVEIDGHNVEGASHSEAVVLLEAAAQNK 793

  Fly   337 LVMITSRRKPNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVGS 401
            .|.:..||....:     |.::....|......:|......    ..:|| |.:::..:|.   :
Worm   794 HVKLIVRRPSRTD-----PARRGSLNSAGPSGSYDVLLHRN----ENDGF-GFVLMSSQHK---N 845

  Fly   402 GIFISDLREGSNAELAG-VKVGDMLLAVNQDVTLESNYDDATGLLK--------------RAEGV 451
            |..:..::.||.|...| :.|||.::|||....|..::.|...|:|              .|..|
Worm   846 GSTVGQIQPGSPAARCGRLSVGDRVIAVNGIDILSLSHPDTISLIKDSGLSVRLTIAPPNTAGPV 910

  Fly   452 VTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEEKPQEP---ATAEIKPNKKI-----LIELKVEK 508
            :.|:..||.....:.....:............||...|   |...:..|.::     ||::.:|:
Worm   911 LPMVSATLGRNFTMNGHYESNYGLPPPPPSVYEKHPPPSYLAFDGLSINDRMSMNGNLIDVTLER 975

  Fly   509 --KPMGVIVCGGKNNHVTTGCVITHVYPEGQVAADKRLKIFDHICDINGTPI----HVGSMTTLK 567
              |..|..:.||: ...:....:..:..:|...||.||::.|.:..|||...    |..::..:|
Worm   976 GTKGFGFSIRGGQ-EFGSMPLFVLRIADDGPAKADGRLQVGDQLTTINGQSTKGMSHDDAIRIIK 1039

  Fly   568 VHQLFHTTYEKAVTLTVFR 586
            .|.:        |.|||.|
Worm  1040 QHTM--------VNLTVLR 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	25/89 (28%)
		PDZ_signaling	259..340	CDD:238492	22/87 (25%)
		PDZ_signaling	377..457	CDD:238492	22/94 (23%)
		PDZ_signaling	500..584	CDD:238492	21/94 (22%)
		PDZ_signaling	597..672	CDD:238492
magi-1	NP_001255577.1	NK	180..>244	CDD:302627
		WW	263..293	CDD:238122
		WW	294..323	CDD:278809
		PDZ	421..510	CDD:214570
		PDZ_signaling	535..600	CDD:238492	23/77 (30%)
		PDZ_signaling	717..800	CDD:238492	22/90 (24%)
		PDZ_signaling	822..902	CDD:238492	20/87 (23%)
		PDZ_signaling	968..1049	CDD:238492	22/89 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910