Protein Alignment inaD and frm-5.1

DIOPT Version :10

• Sequence 1: NP_001246470.1
• Gene: inaD / 37629
• FlyBaseID: FBgn0001263
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001408266.1
• Gene: frm-5.1 / 176822
• WormBaseID: WBGene00001492
• Length: 1567
• Species: Caenorhabditis elegans
• Alignment Length: 489
• Identity: 95/489 - (19%)
• Similarity: 186/489 - (38%)
• Gaps: 109/489 - (22%)

  Fly    30 VTLDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDVRNS 94
            :.|.|......|:.:|.|.:...|     |:::| :|.|:.|.:...:.|||||:.:..:.:...
 Worm  1131 ILLVKDPANGLGLTLVDGNLNGVP-----GVYVK-LVADNGAGMKAGVCVGDRIVQVGTESMEGH 1189

  Fly    95 TEQAVIDLIKEADFKIELEIQTF--------DKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNA 151
            .....::|::....::.:.|...        |.|.|..|.:..:.:....:.:..|....||
 Worm  1190 DRLHAVELVRRCGQRVPMVIARLDGLIRHQKDVSAEMLASAGRKKSFTSSSGDLLNAPNRTN--- 1251

  Fly   152 SGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTA--------------SMRQKHSNYADEDDEDT 202
                  ||.:.........||:   |:..:.|.|              :::.....:.||.||:.
 Worm  1252 ------GQSRTPPAPRKAANRR---QRAVSDFGAIGDALPTLDGDNLINIKAISGLHLDESDEEK 1307

  Fly   203 RDMTGRIRTEAGYEIDR----------------------------ASAGNCKLNKQEKDRDKEQE 239
            .:.  |:.|.:.|..||                            |...|.::.::.::...|..
 Worm  1308 GEY--RLPTTSMYAFDRDDDLQASIKESKKPAPEPKSGELRKYRYARRSNLEIAEEIEEEAVESS 1370

  Fly   240 DEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGHKDRQKMACFVAGVDPNGALGSVDIK 304
            |:.|        :.:..|.:..:|:.|:.:..||:.:|....|   .| :..:....|:...||:
 Worm  1371 DDDG--------QIDEGKRVIDVELDRNENGSLGVQIASLSGR---VC-IKQLTSEPAISHPDIR 1423

  Fly   305 PGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMITSRRKP--NDEGMCVKPIKKFPTASDETK 367
            .||.::.|||..::.:.|....|:.:. .||::|:...|..|  :|:..........|..|
 Worm  1424 VGDVLLYVNGIAVEGKVHQEVVAMLRG-GGDRVVLGVQRPPPAYSDQHHASSTSASAPLIS---- 1483

  Fly   368 FIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVGSGIFISDLREGSNAELAG-VKVGDMLLAVNQD 431
                       |.:.|:....:.:...|.. :..||||.::.:.|.|...| ::|||.|::::.:
 Worm  1484 -----------VMLLKKPMATLGLSLAKRT-MSDGIFIRNIAQDSAASSEGTLRVGDRLVSLDGE 1536

  Fly   432 VTLESNYDDATGL--LKRAEGVVTMILLTLKSEE 463
            ..  ..:..||.|  ||..:|.|.   :|:..|:
 Worm  1537 PV--DGFTPATILEKLKLVQGPVQ---ITVTREQ 1565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ1_INAD-like	29..115	CDD:467276	17/84 (20%)
		PDZ8_MUPP1-PDZ7_PATJ-PDZ2_INAD-like	259..342	CDD:467160	20/82 (24%)
		PDZ3_INAD-like	379..454	CDD:467277	21/77 (27%)
		PDZ4_INAD-like	501..585	CDD:467278
		PDZ5_INAD-like	596..674	CDD:467279
frm-5.1	NP_001408266.1	Protein Kinases, catalytic domain	9..164	CDD:473864
		B41	688..893	CDD:214604
		PH-like	889..1018	CDD:473070
		PDZ_canonical	1130..1210	CDD:467153	17/84 (20%)
		PDZ	1381..1463	CDD:214570	21/86 (24%)
		PDZ_canonical	1486..1562	CDD:467153	21/81 (26%)