DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and Mpdz

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001292213.1	Gene:	Mpdz / 17475	MGIID:	1343489	Length:	2069	Species:	Mus musculus

Alignment Length:	715	Identity:	193/715 - (26%)
Similarity:	317/715 - (44%)	Gaps:	130/715 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VTLDKTGKKSFGICIVRGE---VKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDV 91
            |.|.:...||.||.||.|.   .:.|......|||||.::.||||...|.||.||||:.::|.|:
Mouse  1154 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIIEVDGMDL 1218

  Fly    92 RNSTEQAVIDLIKEADFKIELEIQT-FDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNASG-- 153
            |:::.:..::.|::|...:...:|: .::..:....|.|.|   :..|..|:   :||..|..
Mouse  1219 RDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLPHS---LYPKYSFS---STNPFADSLQ 1277

  Fly   154 ---GQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGY 215
               .|...|.:.:.:..|..|...|                              :..:.:|.|.
Mouse  1278 LTTDQAPSQSESETEKPALCNVPPS------------------------------SPSVFSEMGS 1312

  Fly   216 EIDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRY-NMMKDLRRIEVQRDASKPLGLALAGH 279
            :..:.||       .....|:::||||||:...|.:|| ::...|..||:::..| .|||:|||:
Mouse  1313 DCAQPSA-------TAVSEDEDKEDEFGYSWKNIQERYGSLTGQLHVIELEKGQS-GLGLSLAGN 1369

  Fly   280 KDRQKMACFVAGVDPNGALG-SVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGD-KLVMITS 342
            |||.:|:.|:.|:||.||.| ...::..||::|:||.:|..|.|.|||::.|..... |::.|.:
Mouse  1370 KDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRN 1434

  Fly   343 RRKPNDEGMC-------------------VKPIKKFPTASDETKFIFD----QFPKARTVQVRKE 384
            ....|...:|                   |:|......::.:...:.|    :.||       .:
Mouse  1435 ADAVNQMAVCPGIAADSPSSTSDSPQNKEVEPCSTTSASAADLSSLTDVYQLELPK-------DQ 1492

  Fly   385 GFLGIMVIYGKHAEVGSGIFISDLRE-GSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRA 448
            |.|||.:.   ..:..:|:.|..|.| |..|:...:|.||.:|||:.:|......:....|||.|
Mouse  1493 GGLGIAIC---EEDTINGVMIESLTEHGGAAKDGRLKPGDHILAVDDEVVAGCPVEKFISLLKTA 1554

  Fly   449 EGVVTMILLTLKSEE-AIKAEKAAEEKKKEEAKKEEEKP-----------------------QEP 489
            :..|.   ||:::|. |..|..::......|.|...:.|                       .:|
Mouse  1555 KATVK---LTVRAENPACPAVPSSAVTVSGERKDNSQTPAVPAPDLEPIPSTSRSSTPAVFASDP 1616

  Fly   490 ATAEIKPNKKILIELKVEKKPMGVIVCGGKNNHVTTGCVITH-VYPEGQVAADKRLKIFDHICDI 553
            ||..|.|..:..||:...:..:|:.:.||.:  ...|.:|.| ||.||....|.||...|.|.::
Mouse  1617 ATCPIIPGCETTIEISKGQTGLGLSIVGGSD--TLLGAIIIHEVYEEGAACKDGRLWAGDQILEV 1679

  Fly   554 NGTPIHVGSMTTLKVHQLFHTTYEKAVTLTVFRADPPELEK-----FNVDLMKKAGKELGLSL-- 611
            ||  |.:...|..:...:...|.:: |.||::|.:.|..|:     |.::|.|:.||.||||:
Mouse  1680 NG--IDLRKATHDEAINVLRQTPQR-VRLTLYRDEAPYKEEDVCDTFTIELQKRPGKGLGLSIVG 1741

  Fly   612 SPNEIGCTIADLIQGQYPEIDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEVTRPK 676
            ..|:.|..::|:::|...:.|.:|.:||.|...||:.:.....:...||.|.:.|.|::||.|.|
Mouse  1742 KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRHATQEAVAALLKCSLGAVTLEVGRVK 1806

Fly 677 676
Mouse 1807 1806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	31/87 (36%)
		PDZ_signaling	259..340	CDD:238492	34/82 (41%)
		PDZ_signaling	377..457	CDD:238492	22/80 (28%)
		PDZ_signaling	500..584	CDD:238492	24/84 (29%)
		PDZ_signaling	597..672	CDD:238492	24/76 (32%)
Mpdz	NP_001292213.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..372
		PDZ	375..464	CDD:214570
		PDZ_signaling	553..622	CDD:238492
		PDZ_signaling	694..777	CDD:238492
		PDZ_signaling	994..1064	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1144
		PDZ_signaling	1151..1242	CDD:238492	31/87 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1313		7/64 (11%)
		PDZ	1349..1434	CDD:214570	35/85 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1473		2/23 (9%)
		PDZ_signaling	1483..1563	CDD:238492	26/92 (28%)
		MPDZ_u10	1564..1625	CDD:293272	11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1571..1611		4/39 (10%)
		PDZ	1626..1710	CDD:214570	25/88 (28%)
		PDZ_signaling	1722..1802	CDD:238492	25/79 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1848
		PDZ_signaling	1859..1944	CDD:238492
		PDZ_signaling	1985..2068	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10112
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4314
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760