Protein Alignment inaD and mpz-1

DIOPT Version :10

• Sequence 1: NP_001246470.1
• Gene: inaD / 37629
• FlyBaseID: FBgn0001263
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001364655.1
• Gene: mpz-1 / 174657
• WormBaseID: WBGene00003404
• Length: 2422
• Species: Caenorhabditis elegans
• Alignment Length: 785
• Identity: 183/785 - (23%)
• Similarity: 308/785 - (39%)
• Gaps: 222/785 - (28%)

  Fly    30 VTLDKTGKKSFGICIVRGEVKDS-----PNTKTT--GIFIKGIVPDSPAHLCGRLKVGDRILSLN 87
            |||.:...|||||.||.|.|:.|     |.|..|  |||||.::|:|||...|::.:|||::|:|
 Worm  1477 VTLVREPNKSFGISIVGGRVEVSQKGGLPGTGNTVCGIFIKSVLPNSPAGRSGQMNMGDRVISVN 1541

  Fly    88 GKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSN-GYMQAKNKFNQEQ------ 145
            ..|:|::|.:..::.||.|...:...:|:...:.:....|...|. |.::.:|...:|:
 Worm  1542 DVDLRDATHEQAVNAIKNASNPVRFVLQSLHTNQQNMINSASNSTVGSVRFENAKPEEELPPTAL 1606

  Fly   146 --------TTNNNASGGQGMG------------QGQGQGQGMAGMNRQQSMQKRNTTFTASM--- 187
                    :::.:::....|.            ..:.:.:.....:....:|:.||....||
 Worm  1607 VTPLKPMISSSGSSTSKPAMNFPPPSISTTTTTSMESESKEEEATSSSPDIQRENTVKRRSMDVE 1671

  Fly   188 ---------------RQK--------HSNYADEDDEDTRDMTGRIRTEAGYEID-RASAGNCKLN 228
                           ::|        .||.:.::..|.:::..:...|....:: :.|..:.|.:
 Worm  1672 REQPEANPVEETSIVKEKTPPRKISAKSNSSQKESNDRKEIKKQKSVEREMSVESKKSVRSIKKH 1736

  Fly   229 KQEK------------------------------------------------------------D 233
            :||.                                                            .
 Worm  1737 RQESTIIKKSPSNETAPLIVSDVSSSETHEDEPQAMSPSTSFDTRDADAMRALGIDDDSAAFQIK 1801

  Fly   234 RDKEQEDEFGYTMAKINKRYNM-MKDLRRIEVQR-DASKPLGLALAGHKDRQKMACFVAGVDPNG 296
            .|.|:..:|.||..||.::|:. ..:|..:..:| |..  ||::|||:|||.|...||..|.|:.
 Worm  1802 NDGEEPSKFFYTAGKIERKYDSDGGELVLVACERPDGG--LGISLAGNKDRDKQNVFVVNVRPSC 1864

  Fly   297 ALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMITSRRKPNDEGMCVKPIKKFPT 361
            .|.   |:||||::|:||.:|....|:.||||.:.                    |.
 Worm  1865 PLA---IRPGDELLEINGRLLNKISHVAASAVVRE--------------------CC-------- 1898

  Fly   362 ASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKHAEVGSGIFISDLREGSNAELAGVKVGDMLL 426
                     ||......|..|:.|.|....:.            ||....|.: |.........|
 Worm  1899 ---------DQHQNIEIVLRRRNGALNECAVR------------SDTITSSQS-LPSPPTSPSTL 1941

  Fly   427 AVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEEKPQEPAT 491
            |.::..:........|      ||:                |.||  ..:||..:::...|| .|
 Worm  1942 APSESKSTAPQMPTTT------EGI----------------ENAA--PNQEELSRKKSFSQE-RT 1981

  Fly   492 AEIKPNKKILIELKVEKKPMGVIVCGGKNNHVTTGCVITH-VYPEGQVAADKRLKIFDHICDING 555
            ..|:..::.:||:..:.|.:|:.:.||.:  ...|.|:.| ||.:|..|.|.|||..|.:.::||
 Worm  1982 QAIENGRETMIEIDKDGKGLGLSIVGGAD--TVLGTVVIHEVYSDGAAAHDGRLKPGDQVLEVNG 2044

  Fly   556 TPI----HVGSMTTL-----KVHQLFHTTYEKAVTLTVFRADPPELEK-FNVDLMKKAGKELGLS 610
            |.:    |..|:..|     ||..|.:    :.|.|.:...||.::.. |.:||:||.|:.||:|
 Worm  2045 TSLRGVTHDQSIAYLRRTPPKVRLLIY----RDVNLQLSLLDPTQIYNIFEIDLVKKTGRGLGIS 2105

  Fly   611 L--SPNEIGCTIADLIQGQYPEIDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEVT 673
            :  ..||.|..::::::|...|.|.:|..||.|.:.||..:.|...:...|:.|...|||.:::.
 Worm  2106 IVGRKNEPGVYVSEIVKGGLAESDGRLMTGDQILEVNGKDVRGCMQEDVAAMLKTITGKVHLKLG 2170

  Fly   674 RPKPT 678
            |.|.|
 Worm  2171 RWKIT 2175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ1_INAD-like	29..115	CDD:467276	37/91 (41%)
		PDZ8_MUPP1-PDZ7_PATJ-PDZ2_INAD-like	259..342	CDD:467160	31/83 (37%)
		PDZ3_INAD-like	379..454	CDD:467277	13/74 (18%)
		PDZ4_INAD-like	501..585	CDD:467278	29/93 (31%)
		PDZ5_INAD-like	596..674	CDD:467279	26/79 (33%)
mpz-1	NP_001364655.1	PDZ5_MUPP1-like	836..933	CDD:467157
		PDZ6_MUPP1-like	1047..1135	CDD:467158
		PDZ7_MUPP1-PD6_PATJ-like	1473..1572	CDD:467159	38/94 (40%)
		PDZ_canonical	1828..1910	CDD:483948	35/123 (28%)
		PDZ10_MUPP1-PDZ8_PATJ-like	1987..2072	CDD:467161	27/90 (30%)
		PDZ11_MUPP1-PDZ9_PATJ-like	2087..2173	CDD:467162	28/85 (33%)
		DUF5585	2162..>2290	CDD:465521	6/14 (43%)
		PDZ_canonical	2338..2415	CDD:483948
		PDZ2_MUPP1-like	249..328	CDD:467155
		PDZ_canonical	538..625	CDD:483948
		PDZ_canonical	686..767	CDD:483948