DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaD and smz-2

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_491965.1	Gene:	smz-2 / 172415	WormBaseID:	WBGene00020661	Length:	274	Species:	Caenorhabditis elegans

Alignment Length:	273	Identity:	59/273 - (21%)
Similarity:	104/273 - (38%)	Gaps:	59/273 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 IFISDLREGSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKA 467
            :.|:.::.|:.:| ..:::||.:..||     ..|..|.....:..........:|:.
Worm    27 LVITKIQAGTISE-GKLRIGDQVKKVN-----GQNCKDCNDFFRALRFAAPCAKITVN------- 78

  Fly   468 EKAAEEKKKEEAKKEEEKPQEPATAEIKPNKKILIELK----VEKKP---MGVIVCGGKNNHVTT 525
               .:|||.||.:.....|::.|.. |:..:..:.||.    |:..|   :|:       .|...
Worm    79 ---RDEKKAEELEARVHIPEDRAKI-IQRREGYVYELATLVWVQNGPKLGLGI-------KHFQN 132

  Fly   526 GCVITHVYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKA-VTLTVFRADP 589
            ..:::.|.| |.: |:|.|.:.||:||::|.|:   |...:....|.....||. ||..|.|.|
Worm   133 RVLVSRVDP-GSL-AEKCLVLGDHLCDVDGIPV---SDKDVARDLLVKNIQEKGKVTFVVERPD- 191

  Fly   590 PELEKFNVDLMKKAGKELGLSLSPNEIGCTIADLIQGQYPEIDSKLQRGDIITKFNGDALEGLPF 654
                  ::|..:.|.:.|..:|.              |.|.:........|.:::. .||.||..
Worm   192 ------SIDAKQWAKQALATNLM--------------QPPSVQMNEDVKGIASQYR-QALPGLKP 235

  Fly   655 QVCYALFKGANGK 667
            ....|:..|.|.:
Worm   236 PAKSAMSTGPNAR 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492
		PDZ_signaling	377..457	CDD:238492	9/53 (17%)
		PDZ_signaling	500..584	CDD:238492	24/91 (26%)
		PDZ_signaling	597..672	CDD:238492	14/71 (20%)
smz-2	NP_491965.1	PDZ_signaling	7..77	CDD:238492	9/55 (16%)
smz-2	NP_491965.1	PDZ_signaling	114..188	CDD:238492	22/85 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900