DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaD and Lnx2

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_542985.4	Gene:	Lnx2 / 140887	MGIID:	2155959	Length:	687	Species:	Mus musculus

Alignment Length:	458	Identity:	87/458 - (18%)
Similarity:	161/458 - (35%)	Gaps:	131/458 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PFPELIHMVTLDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSL 86
            |..|:..::...:...:..||.:||       .|...|:||..::....|...|||...||:|::
Mouse   332 PRDEVFQVLLHKRDSTEQLGIKLVR-------RTDEPGVFILDLLEGGLAAQDGRLNSNDRVLAI 389

  Fly    87 NGKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQ--AKNKFNQEQTTNN 149
            ||.|:::.|.:....:|:.:..::.|.|       .:..|..| |||..:  |.:..|..|..::
Mouse   390 NGHDLKHGTPELAAQIIQASGERVNLTI-------ARPGKPQP-SNGSREAGAHSSSNHAQPPSH 446

  Fly   150 NASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAG 214
            :..|..                       ::.|...:.::||
Mouse   447 SRPGSH-----------------------KDLTRCVTCQEKH----------------------- 465

  Fly   215 YEIDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGH 279
                                                           |.|:::..:.||:.:||.
Mouse   466 -----------------------------------------------ITVKKEPHESLGMTVAGG 483

  Fly   280 KDRQ--KMACFVAGVDPNGALG-SVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMIT 341
            :..:  ::..||..|.|:|.|. ...||.||.::.:||..|.|..|..|.|:.|.......|::.
Mouse   484 RGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVILK 548

  Fly   342 SRRKPNDEGMCVKPIKKFPTASDETKFIFDQFP-------------KARTVQVRKE--GFLGIMV 391
            :......| ...:..::.|:|..|.::.....|             ....:.:|:.  |..|..:
Mouse   549 ALEVQIAE-EAAQATEEQPSAFSENEYDASWSPSWVMWLGLPSALHSCHDIVLRRSYLGSWGFSI 612

  Fly   392 IYG-KHAEVGSGIFISDLREGSNAELAG-VKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTM 454
            :.| :........||..:..|:.|...| :|.|||::|||...|:..::.....:||.....||:
Mouse   613 VGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTL 677

  Fly   455 ILL 457
            .::
Mouse   678 TVI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	21/87 (24%)
		PDZ_signaling	259..340	CDD:238492	25/83 (30%)
		PDZ_signaling	377..457	CDD:238492	21/83 (25%)
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
Lnx2	NP_542985.4	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..175
		NPXY motif	207..210
		PDZ	229..315	CDD:214570
		PDZ_signaling	336..418	CDD:238492	22/95 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..454		10/67 (15%)
		PDZ_signaling	463..539	CDD:238492	26/145 (18%)
		PDZ_signaling	596..680	CDD:238492	21/83 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	53	1.000	Inparanoid score	I5446
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.920