DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and PATJ

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens

Alignment Length:	714	Identity:	196/714 - (27%)
Similarity:	301/714 - (42%)	Gaps:	166/714 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PELIH-----MVTLDKTGKKSFGICIVRGE-----VKDSPNTKTTGIFIKGIVPDSPAHLCGRLK 78
            |...|     :|.:.:....|.||.||.|:     :|:....|  |||||.::.||||.....||
Human  1058 PNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELK--GIFIKQVLEDSPAGKTNALK 1120

  Fly    79 VGDRILSLNGKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPR--SNGYMQAKNKF 141
            .||:||.::|.|::|::....::.||.|...:...:|:.        .|.||  .|.:.:| ||.
Human  1121 TGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSL--------SSTPRVIPNVHNKA-NKI 1176

  Fly   142 --NQEQTTNNNASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRD 204
              ||.|.|                         |:..:||..|....|:......|..||.|
Human  1177 TGNQNQDT-------------------------QEKKEKRQGTAPPPMKLPPPYKALTDDSD--- 1213

  Fly   205 MTGRIRTEAGYEIDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRY-NMMKDLRRIEVQRDA 268
                                            |.|:|..:|..||.:|| ::..:|..||:::|
Human  1214 --------------------------------ENEEEDAFTDQKIRQRYADLPGELHIIELEKD- 1245

  Fly   269 SKPLGLALAGHKDRQKMACFVAGVDPNG-ALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNV 332
            ...|||:|||:|||.:|:.||.|::|.| |.....::.|||::|:|..:|..|.|.||||:.|..
Human  1246 KNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTA 1310

  Fly   333 DGD-KLVMITSRRKPNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKEGFLGIMVIYGKH 396
            ... |||.|.:....|.  |.|.|   ||..|.....|.|| .....:...::|          .
Human  1311 PSKVKLVFIRNEDAVNQ--MAVTP---FPVPSSSPSSIEDQ-SGTEPISSEEDG----------S 1359

  Fly   397 AEVGSGIFISDLREGSNAELAGVK--VGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTL 459
            .|||    |..|.|..:.:|..:.  :|..::| :|...||...|:|...:|:.:....   ::.
Human  1360 VEVG----IKQLPESESFKLEDMSQVIGQGMVA-DQQKALEYPPDNAVSQMKQQKYPTK---VSF 1416

  Fly   460 KSEEAIKAEKAAEEKKKEE----AKKEEEKPQEPATAEIKPNKKILIELKVEKKPMGVIVCGGKN 520
            .|:|...|..::......:    ...:.....:|||..|.|.::::||:...:..:|:.:.|||:
Human  1417 SSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKD 1481

  Fly   521 -----------------------NHVTT------GCVITHVYPEGQVAADKRLKIFDHICDINGT 556
                                   :|..|      ..||..||.||..|.|.||...|.|.::||.
Human  1482 TPLFWRLGSPRAWSQHLVRAFMLHHPVTEVEGQNAIVIHEVYEEGAAARDGRLWAGDQILEVNGV 1546

  Fly   557 PI----HVGSMTTLKVHQLFHTTYEKAVTLTVFR-----ADPPELEKFNVDLMKKAGKELGLSL- 611
            .:    |..::|.|:      .|.:| |.|.|:|     .|...||.|.|||.||||:.||||:
Human  1547 DLRNSSHEEAITALR------QTPQK-VRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIV 1604

  Fly   612 -SPNEIGCTIADLIQGQYPEIDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEVTR 674
             ..|..|..|:|:::|...::|.:|.:||.|...||:.:.....:....:.|.|.|.|.:|:.|
Human  1605 GKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR 1668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	31/97 (32%)
		PDZ_signaling	259..340	CDD:238492	36/82 (44%)
		PDZ_signaling	377..457	CDD:238492	16/81 (20%)
		PDZ_signaling	500..584	CDD:238492	29/116 (25%)
		PDZ_signaling	597..672	CDD:238492	27/76 (36%)
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	246..325	CDD:238492
		PDZ_signaling	366..450	CDD:238492
		PDZ_signaling	570..634	CDD:238492
		PDZ	683..772	CDD:214570
		PDZ_signaling	1066..1157	CDD:238492	30/92 (33%)
		PDZ	1236..1321	CDD:214570	37/85 (44%)
		PDZ	1459..1574	CDD:214570	30/121 (25%)
		PDZ_signaling	1586..1666	CDD:238492	28/79 (35%)
		PDZ_signaling	1729..1814	CDD:238492
		PDZ_signaling	1852..1936	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9829
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820