DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and mpdz

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_017212650.1	Gene:	mpdz / 101885491	-ID:	-	Length:	1881	Species:	Danio rerio

Alignment Length:	704	Identity:	188/704 - (26%)
Similarity:	307/704 - (43%)	Gaps:	140/704 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VTLDKTGKKSFGICIVRGE---VKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDV 91
            |.|.|...||.||.||.|.   .:.|......|||||.|:.||||...|.||.||||:.:.|.|:
Zfish  1011 VELLKEAGKSLGISIVGGRGMGCRLSNGEVMRGIFIKHILEDSPAGRNGTLKTGDRIVEVGGVDL 1075

  Fly    92 RNSTEQAVIDLIKEADFKIELEIQTF---DKSDEQQA--------KSDPRSNGYMQAKNKFN--- 142
            |:::.:..::.|:.|...:...:|:.   |:.|.|.:        |..|....:...|.:.:
Zfish  1076 RDASHEQAVEAIRNAANPVVFLVQSIIQKDRPDSQYSVDSPPVIEKCGPALKCFYVPKCQTSVLD 1140

  Fly   143 --QEQT--TNNNASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTR 203
              :|.:  ::||               |...:||.:..       .:::......:..|.|.||
Zfish  1141 PVEEISAFSSNN---------------GSEKLNRDECK-------VSALSLPVVPHVGETDSDT- 1182

  Fly   204 DMTGRIRTEAGYEI-DRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMK-DLRRIEVQR 266
             :|         || ||       |:......|:|:|||:||:..|:::||..:. :|..:::::
Zfish  1183 -LT---------EIPDR-------LDLHHNAPDEEEEDEYGYSWKKVSERYGRLPGELHILQLEK 1230

  Fly   267 DASKPLGLALAGHKDRQKMACFVAGVDPNGALG-SVDIKPGDEIVEVNGNVLKNRCHLNASAVFK 330
            ..: .|||:|||::||.:|:.||.|:||:||.| ...|..|||::|:||.||..|.|.||||:.|
Zfish  1231 GRA-GLGLSLAGNRDRSRMSVFVVGIDPSGAAGQDGHILVGDELLEINGQVLYGRSHQNASAIIK 1294

  Fly   331 NVDGDKLVMITSRRKPNDEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVR-----------KE 384
            :.. .|:.:|..|.......|.|.|:|  .|.|.:|..      :|.:|...           ::
Zfish  1295 SAP-SKVKIIFIRNGDALSQMAVGPMK--DTDSPDTHI------EAESVSSTLDLIQHISLPVED 1350

  Fly   385 GFLGIMVIYGKHAEVGSGIFISDLREGSNAELAGVK--VGDMLLAVNQDVTLE--SNYDDATGLL 445
            |.:|:      ..:..||..|..:.|..   .||.|  .....|.:..|...:  |:....:|
Zfish  1351 GGVGM------EEDSRSGCSIHSVEENG---AAGWKEPQSSFSLTICADSAPQPSSSSQMPSG-- 1404

  Fly   446 KRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEEKPQEPATAEIKPNKKILIELKVEKKP 510
             .:|..:..:.|.|.|.|      ....:.............:|.|..|.|..:..||:...:..
Zfish  1405 -ESEPALNQLSLPLTSSE------PEPIRNSSRCSTPATLASDPTTCPIIPGCETTIEICKGRTG 1462

  Fly   511 MGVIVCGGKNNHVTTGCVITH-VYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFHT 574
            :|:.:.||.:  ...|.:|.| ||.||..:.|.||...|.|.::||..:.|             .
Zfish  1463 LGLSIVGGCD--TLLGAIIIHEVYEEGAASKDGRLWAGDQILEVNGIDLRV-------------A 1512

  Fly   575 TYEKA----------VTLTVFRADPPELEK-----FNVDLMKKAGKELGLSL--SPNEIGCTIAD 622
            |:::|          |.|:|||.:....|:     .:|:|.||.|:.||||:  ..::.|..::|
Zfish  1513 THDEAINVLRQTPQRVRLSVFRDEAQYKEEELWDSLSVELQKKPGQGLGLSIIGRRSDTGVFVSD 1577

  Fly   623 LIQGQYPEIDSKLQRGDIITKFNGDALEGLPFQVCYALFKGANGKVSMEVTRPK 676
            :::|...|.|.:|.:||.|...||:.:.....:...:|.|.:.|.:.:|:.|.|
Zfish  1578 IVKGGVVEQDGRLLQGDQILSVNGEDVRSATQESVASLLKSSAGPIRLEIGRFK 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	33/87 (38%)
		PDZ_signaling	259..340	CDD:238492	35/81 (43%)
		PDZ_signaling	377..457	CDD:238492	15/94 (16%)
		PDZ_signaling	500..584	CDD:238492	24/94 (26%)
		PDZ_signaling	597..672	CDD:238492	23/76 (30%)
mpdz	XP_017212650.1	L27_2	6..62	CDD:312549
		PDZ_signaling	103..189	CDD:238492
		PDZ_signaling	223..301	CDD:238492
		PDZ	333..420	CDD:214570
		PDZ_signaling	518..587	CDD:238492
		PDZ	652..741	CDD:214570
		PDZ_signaling	857..926	CDD:238492
		PDZ_signaling	1008..1099	CDD:238492	33/87 (38%)
		PDZ	1222..1308	CDD:214570	37/87 (43%)
		MPDZ_u10	<1416..1450	CDD:318804	7/39 (18%)
		PDZ_signaling	1451..1532	CDD:238492	24/95 (25%)
		PDZ_signaling	1550..1627	CDD:238492	23/76 (30%)
		PDZ_signaling	1679..1764	CDD:238492
		PDZ_signaling	1797..1880	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010