DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and USH1C

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_016872564.1	Gene:	USH1C / 10083	HGNCID:	12597	Length:	956	Species:	Homo sapiens

Alignment Length:	500	Identity:	95/500 - (19%)
Similarity:	189/500 - (37%)	Gaps:	126/500 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 KDLRRIEVQRDASKPLGLALAGHKDRQKMAC--FVAGVDPNGALGSVDIKPGDEIVEVNGNVLKN 319
            :.|:.:.:.|...:.|||::.|..:   ..|  |::.:...|...||.::.|||||.:||..:.:
Human    83 RKLKEVRLDRLHPEGLGLSVRGGLE---FGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISS 144

  Fly   320 RCHLNASAVFKNVDGDKLVMITSRRKPNDEGMCVKPIKKFPTASDETKFIFDQF----------- 373
            ..|   ..|...:...|.|.|..|.      :.:.|:|..|......::: |||
Human   145 CTH---EEVINLIRTKKTVSIKVRH------IGLIPVKSSPDEPLTWQYV-DQFVSESGGVRGSL 199

  Fly   374 --PKARTVQVRKEGFLGIMVIYGKHAEVGS------GIFISDLREGSNAELAGVKVGDMLLAVNQ 430
              |..|. ...|:.|:.::...|....:.|      |||||.::.||.:...|:::||.::.||.
Human   200 GSPGNRE-NKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNG 263

  Fly   431 DVTLESNYDDATGLLKRAEGVVTMIL---------------------------LTLKSEEAIKAE 468
            ......::.:|..:||.:..:...|:                           |.::...|:::.
Human   264 VDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESN 328

  Fly   469 KAAEEKKKEEAKKEEEKPQEPATAEIKPNKKI--LIELKVEKKPMGVIVCGGKNNHVTTGCVITH 531
            |..:|:::.|.::.:|..|:.|....:..|::  ::|.:.:.|.......|.|...:....:...
Human   329 KILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAE 393

  Fly   532 VYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKAV--------TLTVFRAD 588
            |:|    ...::.|.|......:|.               |.|..:|..        :|...|.:
Human   394 VHP----VPLRKPKSFGWFYRYDGK---------------FPTIRKKGKDKKKAKYGSLQDLRKN 439

  Fly   589 PPELE------KFNVDLMKKAGKELGLSLSPNEIGCTIADLIQGQYPEIDSKLQRGDIITKFNGD 647
            ..|||      |...::::|. |:|.::....|:                |:.:|.|:      :
Human   440 KKELEFEQKLYKEKEEMLEKE-KQLKINRLAQEV----------------SETEREDL------E 481

  Fly   648 ALEGLPF---QVCYALFK---GANGKVSMEVTRPKPTLRTEAPKA 686
            ..|.:.:   ::|....:   .|:.::|...|.|.|...:.:|.|
Human   482 ESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLA 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492	22/82 (27%)
		PDZ_signaling	377..457	CDD:238492	21/112 (19%)
		PDZ_signaling	500..584	CDD:238492	13/93 (14%)
		PDZ_signaling	597..672	CDD:238492	11/80 (14%)
USH1C	XP_016872564.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810