DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and il16

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_021333386.1	Gene:	il16 / 100534674	ZFINID:	ZDB-GENE-130103-3	Length:	1540	Species:	Danio rerio

Alignment Length:	446	Identity:	94/446 - (21%)
Similarity:	181/446 - (40%)	Gaps:	74/446 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KDVRNS-TEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDP----------RSNGYMQAKNKFN 142
            |.|.:| |||..:...|.:   :|.|..|..::.::...|:.          ||:...:|..:..
Zfish  1099 KPVSSSETEQEPVSSTKSS---VETEPVTSAETKQEPVSSEKDLPSVTHVPRRSSSSKEAPGEKA 1160

  Fly   143 QEQTTN-----------NNASGGQGMGQGQGQGQGM----------AGMNRQQSMQ-----KRNT 181
            ::..|:           :.:|.|......:|:..|:          |.|...||:.     :...
Zfish  1161 EDAGTHAVSLRTRSLPLSPSSDGPISSGLEGESLGIILSFSNQVSSALMRSMQSLPQSPCIRLGN 1225

  Fly   182 TFTASMRQKHSNYADEDD--EDTRDMTGRIRTEAGYEIDRASAGNCKLNKQEKDRDKEQEDEFGY 244
            .::|.......|..:||.  |:....|.....|.|:.:..|......:.:.|:.:..:.:.|...
Zfish  1226 PWSAPPGSPLHNPIEEDSAAENPHASTALENNEKGFSVSLAELRERTIERGEECKTDDWKPEQAL 1290

  Fly   245 TMA---------------KINKRYNMMKD-----LRRIE------VQRDASKPLGLALAGHKDRQ 283
            |.|               :|.:....:||     ||::|      :.::....||.::||..|.:
Zfish  1291 TSASAACAQSMLSVLPQPEIQRMIQEVKDLDEDTLRQLEDIHVVILHKEEGAGLGFSIAGGIDLE 1355

  Fly   284 KMACFVAGVDPNG-ALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMITSRRKPN 347
            ..|..|..|.|:| |.....|:.|||::.:||..|||..|.:|:|:.:.....|..::...:..:
Zfish  1356 NKATTVHRVFPSGLAAQEGTIEKGDEVLSINGQTLKNVTHSDATAILRQSRTLKQAVVVVSKNKD 1420

  Fly   348 DEGMCVKPIKKFPTASDETKFIFDQFPKARTVQVRKE-GFLGIMVIYGKHAEVGS-GIFISDLRE 410
            .||......:...:...|:....|...:..|.::.|. |.:|..:..||.:..|. .:.::.:..
Zfish  1421 AEGKSANANESSCSGGAESSIAGDDGGEVVTFELEKNAGGVGFSLEGGKGSISGDRPLAVNRIFT 1485

  Fly   411 GSNAELAGVKVGDMLLAVNQDVTLE--SNYDDATGLLKRAEGVVTMILLTLKSEEA 464
            ||:||..|:|.||.:|.: ||.:|:  :.::..|.:....:|..|:|:...:.|::
Zfish  1486 GSDAEQKGLKSGDEVLQI-QDSSLQGLTRFEAWTLIKNLNDGRFTLIVKRRRCEQS 1540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	9/26 (35%)
		PDZ_signaling	259..340	CDD:238492	27/87 (31%)
		PDZ_signaling	377..457	CDD:238492	23/83 (28%)
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
il16	XP_021333386.1	PDZ_signaling	350..433	CDD:238492
		PDZ_signaling	489..571	CDD:238492
		MGC-24	620..>696	CDD:310122
		GREB1	<795..>990	CDD:318077
		Atrophin-1	1006..>1234	CDD:331285	24/137 (18%)
		PDZ_signaling	1331..1406	CDD:238492	23/74 (31%)
		PDZ	1448..1535	CDD:214570	23/87 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910