DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and lnx1

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_017950997.2	Gene:	lnx1 / 100487348	XenbaseID:	XB-GENE-952178	Length:	742	Species:	Xenopus tropicalis

Alignment Length:	742	Identity:	138/742 - (18%)
Similarity:	267/742 - (35%)	Gaps:	164/742 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SFGMHNPFPELIHMVTLDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPA--------- 71
            ||.:|..|..:.....|.:|.|||                   .|.:|.::...|.
Frog    72 SFLVHEDFCPVDRKHILLQTCKKS-------------------TILVKNLLDKLPVICPFKEHCT 117

  Fly    72 ----------HLCGRLKVGDRILSLNGKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAK 126
                      |...|.| |.....|..:..|.|.:.:       ||....|::.....|.|..|
Frog   118 DIVQRCDLEEHFQNRCK-GASHYGLTKERKRRSQDSS-------ADCSSSLDLTVAAVSPELSA- 173

  Fly   127 SDPRSNGYMQAKNKFNQEQTTNNNASGGQGMGQGQG--QGQGMAGMNRQQSMQKRNTTFTASMRQ 189
                     .|......|:|..:|.:.....|:...  :.:....:||     .||..|..|
Frog   174 ---------SAAIALATEETGQDNPAFSPAKGESHTACEAEENCRLNR-----NRNRNFERS--- 221

  Fly   190 KHSNYADEDDEDTRDMTGRIRTEAGYEIDRASAGNCKLNKQEKDRDKEQ-----EDEFGYTMAKI 249
                       ..|.::.:....|...:.|..:|:..::..:::|...|     ||..|     :
Frog   222 -----------TVRSLSFKKLNRAFSVLRRTKSGSSVVHASDRERANLQNANIVEDPMG-----L 270

  Fly   250 NKRYNMMKD--LRRIEVQR-DASKPLGLALAGHKDRQKMACFVAGVDPNGALG-SVDIKPGDEIV 310
            .::|:::.|  :..|::.| |.::.||:.:.|..:.......:..:..:|.:| ...:.|||.|:
Frog   271 PRQYHLIPDGEITCIKINRADLNEILGIRIVGGNETPLTQIIIQHIYQDGVIGRDGRLLPGDMIL 335

  Fly   311 EVNGNVLKNRCHLNASAVFKNVDGDKLVMIT----SRRKPNDEGMCVKPIKKFPTASDETKFIFD 371
            :|||..:.:..|..|.:|.:  ...|::.:|    .|.|....|:   .:::.....|....:.:
Frog   336 KVNGIDISSVPHTYALSVLR--QPSKVLRLTVLREQRYKCRTNGV---NMEQHSPQDDSIHVVLN 395

  Fly   372 QFPKARTVQVRKEGFLGIMVIYGKHAEVGSGIFISDLREGSNAELAG-VKVGDMLLAVNQDVTLE 435
            :  .:..||      |||.::..:..   .||:|.:|.||..|...| ::..|.:|::|......
Frog   396 K--SSHDVQ------LGIKLVRRRDE---PGIYIFNLLEGGVAARDGYLQENDRVLSINGHDLRN 449

  Fly   436 SNYDDATGLLKRA-EGVVTMILLTLKSEEAIKAEKAAEEKKKEE---AKKEEEKPQEPATAEIKP 496
            ...:.|..|::.: |||..::....:.:.....::|......:.   ...|.....:.|:..:..
Frog   450 GTPEIAAQLIQASEEGVYFIVSRHSRHQTPDILQEARWHNNNDSPATCTNERNYFNKNASRTVLC 514

  Fly   497 NKKILIELKVEKKPMGVIVCGGKNN-HVTTGCVITHVYPEGQVAADKRLKIFDHICDINGTPIHV 560
            ::|::...|...:.:|:.|.||.:| .......:|.|..:|.:..|.|||..|.:.::||  |::
Frog   515 HEKVVSITKDNTESLGMTVAGGASNWEWDLPIFVTSVDADGVIGRDGRLKTGDILLNVNG--INL 577

  Fly   561 GSMTTLKVHQLFHTTYEKAVTLTVFRADPPELEKFNVD--------------------------- 598
            ..::..:...|...:...:|.|........|.|:.|::
Frog   578 TGVSRSEAVSLLKNSSSSSVVLKALEIKEYEPEEDNLNNALYMDYLQNGSEQNREWSPVWVMWLN 642

  Fly   599 ------------LMKKAGKELGLSLSPNEIGCT------IADLIQGQYPEIDSKLQRGDIITKFN 645
                        |.:.....||.|:......|:      |..:::|.....|.:|:.|||:.:.|
Frog   643 LPHYLYSCREVVLRRNTAGSLGFSIVGGSDDCSRIKPFFIKSILEGTPAHHDGRLRCGDILLEVN 707

  Fly   646 GDALEGLPFQVCYALFKGANGKVSMEV 672
            |....|:|:.....:.|...|:|.:.:
Frog   708 GRCTSGMPYNSLVRMLKEIRGRVVLTI 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	18/106 (17%)
		PDZ_signaling	259..340	CDD:238492	19/82 (23%)
		PDZ_signaling	377..457	CDD:238492	21/81 (26%)
		PDZ_signaling	500..584	CDD:238492	20/84 (24%)
		PDZ_signaling	597..672	CDD:238492	19/119 (16%)
lnx1	XP_017950997.2	mRING-HC-C3HC3D_LNX1	43..84	CDD:319693	4/11 (36%)
		PDZ_signaling	282..366	CDD:238492	20/85 (24%)
		PDZ_signaling	390..470	CDD:238492	21/90 (23%)
		PDZ_signaling	516..>585	CDD:238492	18/70 (26%)
		PDZ_signaling	651..735	CDD:238492	19/84 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010