Protein Alignment CG13531 and SPG11

DIOPT Version :9

• Sequence 1: NP_001286748.1
• Gene: CG13531 / 37627
• FlyBaseID: FBgn0034786
• Length: 1815
• Species: Drosophila melanogaster
• Sequence 2: NP_079413.3
• Gene: SPG11 / 80208
• HGNCID: 11226
• Length: 2443
• Species: Homo sapiens
• Alignment Length: 2041
• Identity: 452/2041 - (22%)
• Similarity: 769/2041 - (37%)
• Gaps: 572/2041 - (28%)

  Fly     2 HSAQAQAQ--------ARDKIFKNWRGISEVT-IIKEVA--TKGEHIDLCM-------------- 41
            ||||...:        ..|.:.||  .|.|.: ::|.:.  .||:.:.:|.
Human   713 HSAQKLEELIGIGLNLVFDNLKKN--NIKEASELLKNMGFDVKGQLLKICFYTTNKNIRDFLVEI 775

  Fly    42 ----EYWAQKRKIPVSEYRHYFYDVVQAYVQRLLS----ERLVCKAEDVIRNVDRDVKCFFFQFA 98
                .|:::|.|..: ::.|....:...:.|..:.    .|...|.:|..::  :.|...|.::
Human   776 LKEKNYFSEKEKRTI-DFVHQVEKLYLGHFQENMQIQSFPRYWIKEQDFFKH--KSVLDSFLKY- 836

  Fly    99 CECQDEELSEFVLDHLRSREPLMYEQEEPVLAYHWSLVQQLRECEALVAKHRTQLPRVHIEAMMT 163
             :|:||                 :.:::..:..:|:|.......|:::      |||:.
Human   837 -DCKDE-----------------FNKQDHRIVLNWALWWDQLTQESIL------LPRIS------ 871

  Fly   164 LPEQALQLLLVELYFANGNESLLGSLSKDMVWQHLVDSDEQAKLQRWCRLQEEGFVSQETLSPLE 228
             ||:                  ..|.|.:.:|::|....:...:..|  :.|  |.:|.:.:.|:
Human   872 -PEE------------------YKSYSPEALWRYLTARHDWLNIILW--IGE--FQTQHSYASLQ 913

  Fly   229 QSFTAWKIDATMYEYAVEELQQ--------PSEVLRNFFARAGYFFMDESEDIPSLLRRLCTMEC 285
            |:  .|.:      ..|:.:.|        .:|:| :..||.|.|...|.||....|.||..:.
Human   914 QN--KWPL------LTVDVINQNTSCNNYMRNEIL-DKLARNGVFLASELEDFECFLLRLSRIG- 968

  Fly   286 LGKHADLLSRQPLAKYLLDRG------------QYSL-----LLMECVPIA--SLELLAGTETHQ 331
             |...|.|   |:..|....|            ::||     :.::|..::  :...|...|.|:
Human   969 -GVIQDTL---PVQNYKTKEGWDFHSQFILYCLEHSLQHLLYVYLDCYKLSPENCPFLEKKELHE 1029

  Fly   332 -EPLINLIVDIK--TNSLTENE-GFELISKSVQAYLEKTHDTVDS--FEGHPLL----TFYDFLG 386
             .|....:|..:  .::||:.: .|:....:.|..:.....:|.|  .|||.||    |.|...|
Human  1030 AHPWFEFLVQCRQVASNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGHTLLALATTMYSPGG 1094

  Fly   387 ---------QEPSVRSLEGFLTSTNLGRVPYLKS--------------------LIARFDHGPTS 422
                     .|..::.::..|....|...|.||:                    ||........|
Human  1095 VSQVVQNEENENCLKKVDPQLLKMALTPYPKLKTALFPQCTPPSVLPSDITIYHLIQSLSPFDPS 1159

  Fly   423 CNFGLPTAHDLFMKFKHVNLPLLATAGHGELVCFSNARLSQRYARKSQLNYTHYLKQQRSAYAV- 486
            ..||..:|:.|.:.....:||      |     ||:..|..:||...:||:.:||...|.::|.
Human  1160 RLFGWQSANTLAIGDAWSHLP------H-----FSSPDLVNKYAIVERLNFAYYLHNGRPSFAFG 1213

  Fly   487 YYLITEQLQLYGQITKTQLFHACETVTQIALQHAGDDELV------------THCVACCEMLGFD 539
            .:|:.|.::             .:|..|: :|..|::..|            ..||...|:||.|
Human  1214 TFLVQELIK-------------SKTPKQL-IQQVGNEAYVIGLSSFHIPSIGAACVCFLELLGLD 1264

  Fly   540 TQPLR---------------------SFL--LLQRKLPKCETGQ--SYSELL-----GEWD---- 570
            :..||                     ||:  .:..||.|...|:  :..|||     |.|:
Human  1265 SLKLRVDMKVANIILSYKCRNEDAQYSFIRESVAEKLSKLADGEKTTTEELLVLLEEGTWNSIQQ 1329

  Fly   571 RDLVEMLEANPSEFPLELYQSLMRLAIRDTPGKLPMDLLKRYASKNNWWHLLLVFQFFDLPLSEL 635
            :::..:...:.|::.|.:  ...||...    ||.:..|:..|..|:|...::..|..:...:|:
Human  1330 QEIKRLSSESSSQWALVV--QFCRLHNM----KLSISYLRECAKANDWLQFIIHSQLHNYHPAEV 1388

  Fly   636 KKLLPHFKSSPIGVHLLRALSYESSGDRHHKRTLQRPTRRSGETQTNSSQETMTNSSHSSNQ--D 698
            |.|:.:|  ||:....|| |::|                         :..::..|...|:|  :
Human  1389 KSLIQYF--SPVIQDHLR-LAFE-------------------------NLPSVPTSKMDSDQVCN 1425

  Fly   699 SSVQQLQRNTDQSLCTLLTHTARQDVFAIIL-CSTNSLPDELIATTPKFLEMMVGNSSHCSSINL 762
            ...|:||.:..:          ..|:|.|:| ||..  ||                |.|.    |
Human  1426 KCPQELQGSKQE----------MTDLFEILLQCSEE--PD----------------SWHW----L 1458

  Fly   763 LRHCIRQELPILAVLAATISEQNRDWCWIVWLSVASGQWSLQLQEASKVRDENRSE-W------- 819
            |...::|:.|||:|||:.:...:...|..||: :.|.:.::..:....::|..... |
Human  1459 LVEAVKQQAPILSVLASCLQGASAISCLCVWI-ITSVEDNVATEAMGHIQDSTEDHTWNLEDLSV 1522

  Fly   820 VWSVIRGAVAGGHLNALLHSLEIFHPDCKLT------HLCRFLQLTGHQEDFSDATIVELRQFFF 878
            :|   |..:.......|:...::|..|..|.      .||.|.:  .::|  ::|.::|.::...
Human  1523 IW---RTLLTRQKSKTLIRGFQLFFKDSPLLLVMEMYELCMFFR--NYKE--AEAKLLEFQKSLE 1580

  Fly   879 S---------------WSQDSVALPLCGPLPRKQLMQRSIGLLLIQLQSNFDCILQQQRFLECIC 928
            :               |.:|.|...|              .|:|.|.::.::.....|.|:|
Human  1581 TLNTAATKVHPVIPAMWLEDQVCFLL--------------KLMLQQCKTQYELGKLLQLFVE--- 1628

  Fly   929 R----SDVGDICDLLDFCLLHKVFGVAATWLRELSIDLEQLGRRDSPEYKRLVDALTEARAYEEA 989
            |    ||..|:..|...|.:.|...:|.......|..:|.|    ..|.:.:::.|.....:..|
Human  1629 REHLFSDGPDVKKLCILCQILKDTSIAINHTIITSYSIENL----QHECRSILERLQTDGQFALA 1689

  Fly   990 LQLATLLQLPLTDIVYGKWMTE-------LEAGQLRP---------HEEYEKDIQQHALAPAILV 1038
            .::|.|.:||:.::|. |.:|:       :|...|:.         ||.::|    ::::.....
Human  1690 RRVAELAELPVDNLVI-KEITQEMQTLKHIEQWSLKQARIDFWKKCHENFKK----NSISSKAAS 1749

  Fly  1039 NFLLQAASV-----VGQVSLRRYELLQSTLGVIKKHHLFPNES---FDR-DQIEYDMVLCYL--- 1091
            :|....|.|     .|..|:....||.:..|     |....|.   .|: :::|..:.||.:
Human  1750 SFFSTQAHVACEHPTGWSSMEERHLLLTLAG-----HWLAQEDVVPLDKLEELEKQIWLCRITQH 1809

  Fly  1092 ---QLPEEQLP----QLSIYHSEYFEQIMLQERCVLYKSFSELKELAGIDDL---SIADKTVLTS 1146
               :..||..|    |:|......|:.:..:      .|||:|..|.....|   |:..|....:
Human  1810 TLGRNQEETEPRFSRQISTSGELSFDSLASE------FSFSKLAALNTSKYLELNSLPSKETCEN 1868

  Fly  1147 EM----EDRLNTLLNTLLDKGDIVEALRLQELFEFRPNDLRFIVFAMALAEGMTSISNLSSKERQ 1207
            .:    ::.||.|:..|||.|.:.||.|:...|.|...|:..::...|||.|..|:.:|..:...
Human  1869 RLDWKEQESLNFLIGRLLDDGCVHEASRVCRYFHFYNPDVALVLHCRALASGEASMEDLHPEIHA 1933

  Fly  1208 LL--GEIEKSAFPKFNRITLNQNVITRWDSDLSDTCSDSV--AMEFEEIPSKEKQQT-LDTLLGI 1267
            ||  .|:.:...|               |..|....|.|.  :.:|..:||..:..| |:.|.
Human  1934 LLQSAELLEEEAP---------------DIPLRRVHSTSSLDSQKFVTVPSSNEVVTNLEVLT-- 1981

  Fly  1268 GSKLKYGVELGRRIVLAYRAAMYLDKEYLDVLRTKDTGILLKSAAAE--DCLQRLLVVSDIQIST 1330
             ||..:|....|:::..|..|..|...|.||.......:|.|..|::  |..:|    :...|||
Human  1982 -SKCLHGKNYCRQVLCLYDLAKELGCSYTDVAAQDGEAMLRKILASQQPDRCKR----AQAFIST 2041

  Fly  1331 R-MTPKEIAECLALELTTCIVRPRFYIFHAREQPRNALRNADLWGHSIDRDFHLFLELAPNSTML 1394
            : :.|..:||.:|.|:|                 |..|.::...||.
Human  2042 QGLKPDTVAELVAEEVT-----------------RELLTSSQGTGHK------------------ 2071

  Fly  1395 GNCLLEYCDALKTYRRYQEGKPFEETEAFENLSKII---TLYGLP-----TPSPTGTMSGIPQVL 1451
                             |...|.||::.|..|:.:.   ||.|:.     :..|.|.:|
Human  2072 -----------------QMFNPTEESQTFLQLTTLCQDRTLVGMKLLDKISSVPHGELS------ 2113

  Fly  1452 SHKKQNQIYVELLIKAHLCFVHECSMEGIVSVLQKAKAL-NTKLAQAKSWSLIVRLLIGIARYRE 1515
                   ...||||.||.||...|.||||:.|||.|..| :..||.::.:.|:||||.||.||.|
Human  2114 -------CTTELLILAHHCFTLTCHMEGIIRVLQAAHMLTDNHLAPSEEYGLVVRLLTGIGRYNE 2171

  Fly  1516 MFYCFDSLIENEQFESLLGQFDEDQKGGLRQAILSYLREYQPKNGKELLRLAALHFLMYKELAEM 1580
            |.|.||.|.:...||.|:.: ..|..|.|:.|:|.|::..:| ...|...:.||.|.|.:|:.
Human  2172 MTYIFDLLHKKHYFEVLMRK-KLDPSGTLKTALLDYIKRCRP-GDSEKHNMIALCFSMCREIG-- 2232

  Fly  1581 WTTEAQEIVTKIQAFAAQS----NKLKCSVEVQTLLQQALENYTHATENYLLDNKLLLAQQSVSR 1641
               |..|...:||....:|    :.||...:::.||.:||.....|.|:|..|:.:..||.....
Human  2233 ---ENHEAAARIQLKLIESQPWEDSLKDGHQLKQLLLKALTLMLDAAESYAKDSCVRQAQHCQRL 2294

  Fly  1642 AELMAMQLDLCNKALEKRHSNNANHLCVSVIGVRSREQFRELVNVHLSVP---QALILSRAYGYD 1703
            .:|:.:|:...|........|...|               :|::..|::|   ||.|::.||.:.
Human  2295 TKLITLQIHFLNTGQNTMLINLGRH---------------KLMDCILALPRFYQASIVAEAYDFV 2344

  Fly  1704 ISWSEAILSQFVVLQG-VNYLQEYLCHQRINDDVIEQIVKGYLLHIQSNATNSKQEESMVQLVGL 1767
            ..|:| ||.|.|:|:| .|||:|:...:.:...:.|:|.|.|..|..::..    .|::.:|:..
Human  2345 PDWAE-ILYQQVILKGDFNYLEEFKQQRLLKSSIFEEISKKYKQHQPTDMV----MENLKKLLTY 2404

  Fly  1768 IKSVVLKYKLASILGFKSIVMSLIND 1793
            .:.|.|.||||....|..||..|:.|
Human  2405 CEDVYLYYKLAYEHKFYEIVNVLLKD 2430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13531	NP_001286748.1	Spatacsin_C	1452..1746	CDD:291322	97/302 (32%)
SPG11	NP_079413.3	Spatacsin_C	2095..2387	CDD:291322	102/327 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159791
Domainoid	1	1.000	121	1.000	Domainoid score	I5716
eggNOG	1	0.900	-	-		E1_KOG1884
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4051
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29578at33208
OrthoFinder	1	1.000	-	-		FOG0006966
OrthoInspector	1	1.000	-	-		oto89326
orthoMCL	1	0.900	-	-		OOG6_107425
Panther	1	1.100	-	-	LDO	PTHR13650
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5803
SonicParanoid	1	1.000	-	-		X5859
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790