Protein Alignment CG13531 and spg11

DIOPT Version :9

• Sequence 1: NP_001286748.1
• Gene: CG13531 / 37627
• FlyBaseID: FBgn0034786
• Length: 1815
• Species: Drosophila melanogaster
• Sequence 2: NP_001181923.1
• Gene: spg11 / 793551
• ZFINID: ZDB-GENE-101017-1
• Length: 2379
• Species: Danio rerio
• Alignment Length: 2032
• Identity: 427/2032 - (21%)
• Similarity: 749/2032 - (36%)
• Gaps: 551/2032 - (27%)

  Fly     6 AQAQARDKIFKNWRGISEVTI--IKEVATKGEHIDLCMEYWAQKRKIPVSEYRHYFYDVVQAYVQ 68
            :.|||    |...||.:|.|:  |:....|..|..|.:.                  |:.||
Zfish   659 SHAQA----FLRRRGSAEHTLQDIRRTGLKHTHTCLTLR------------------DLQQA--- 698

  Fly    69 RLLSERLVCKAEDVIRNVDRDVKCFFFQFACECQDEELSEFVLDHLRSREPLMYEQEEPVLAYHW 133
            ..|...:....::.:.|:     |.:      ..|.:|..|:::.|:.:..|..::.:.|...|
Zfish   699 TTLLTHMGFNVKEQLHNI-----CVY------TADRDLRAFMVEELQKQHHLSADELKQVNFIH- 751

  Fly   134 SLVQQL------RECEALVAKHRTQLPRVHIEAMMTLPE-------------QALQLLLVELYFA 179
             .::.|      |....|.|....|:.|...::...|.:             ..|:|..|:.:..
Zfish   752 -TIESLCSKPANRSSRRLDANRVLQVSRCDPQSRRLLEKLLQDSDSSSTSLLDPLRLHWVKHWDR 815

  Fly   180 NGNESLLGS-------LSKD--MVWQHLVDSDEQAKLQRWCRLQEEGFVSQE-TLSPLEQSFTAW 234
            :....:|.|       .|.|  ::|.:|....:..:...|  |.......:| :.:|.....||
Zfish   816 DAQTHILLSRTHTHTQCSGDAAVLWAYLTSLHDSVRCSAW--LSSSSVCDRESSAAPCWPQLTA- 877

  Fly   235 KIDATMYEYAVEELQQPSEVLRNF----FARAGYFFMDESEDIPSLLRRL--------------- 280
                    :.::...:..|.|.|.    .||.|.|...|.:|...||.||
Zfish   878 --------HVLDTCTRCGEHLHNIILDQLARQGQFVPAEMQDFQQLLWRLAQAGGVMHDGKEPSL 934

  Fly   281 --------------CTME----------CLGKHADLLSRQPLAKYLLDRGQYSLLLMECVPIASL 321
                          |:.|          ||..:...|    |..||   ..|.|....|
Zfish   935 PQAGGVMHDGKELCCSQEQEFHQRFILHCLENNLQFL----LYTYL---EHYGLSPENC------ 986

  Fly   322 ELLAGTETHQE-PLINLIVDIK--TNSLTENE-GFELISKSVQA-YLEKTHDTVDS--FEGHPLL 379
            .||:.:...:. |...:::.::  |..|||.| .||....:.|. .|..:..::.|  .|||.||
Zfish   987 PLLSDSSVCESFPCFQMMLKLQKITTHLTEPECVFEASLAAAQVLLLPGSQASISSVLLEGHSLL 1051

  Fly   380 TFYDFL----GQEPSVRSLEGFLTSTNLGRVPYLKSLIARF----DHGPTSCNFGLPTAHDL--- 433
            |....:    |.:.:|.:::..|....|.:.|.||:  |.|    ..|..|....|.:.|.|
Zfish  1052 TLATAMFTAGGIQQAVSTVDPQLLRMALRQYPQLKT--ALFPQSGPRGDVSLYHLLQSLHPLDSS 1114

  Fly   434 -FMKFKHVNLPLLATAGHGELVCFSNARLSQRYARKSQLNYTHYLKQQRSAYAVYYLITEQLQLY 497
             ...::..|....::....|...||::.|...:|....|::.::|:..|.|:|....:|:.|:..
Zfish  1115 RLFGWQSANSVSASSEASSEPPHFSSSHLVSNFAIVENLDFLYFLRHGRPAFAYAVYLTQHLRDC 1179

  Fly   498 GQITKTQLFHACETVTQIALQHAGDDELVTHCVACCEMLGFDTQPLRSFLLLQRKLPK-----CE 557
            .. ||.||..|.:....:||.:.....:.:.||..||::|..:..||:.|.....:.|     .|
Zfish  1180 SN-TKLQLSMAVDQSYSLALLNFSSASVSSACVCFCELMGVCSLKLRTDLRTLNLIHKHWSQSRE 1243

  Fly   558 TG----------QSYSELLGEWDR---DLVEMLEANPSEFPLELYQSLMRLAIRDTPGK------ 603
            .|          :..|:|:....|   ||:..|||                ||||...|
Zfish  1244 DGDADSLRHTLVEKASQLISAEHRAAQDLLLHLEA----------------AIRDALEKKTISRW 1292

  Fly   604 ---------LPMDLLKRY------------ASKNNWWHLLLVFQFFDLPLSELKKLLPHFKSSPI 647
                     ||:...:.:            |....|.|.||..|....|..:::.|...| |..:
Zfish  1293 SFEAAQEWALPVQFCRLHALPLSSAYPLDCAHDGQWLHFLLFVQTHQYPPQQVRFLSESF-SPAL 1356

  Fly   648 GVHLLRALSYESSGDRHHKRTLQRPTRRSGETQTNSSQETMTNSSHSSNQDSSVQQLQRNTDQSL 712
            ..|:  :|:::.         |:.|....|.:.|..|.:      .||:..:
Zfish  1357 QSHI--SLAFQD---------LRSPIEDQGVSVTPPSPD------ESSDWPT------------- 1391

  Fly   713 CTLLTHTARQDVFAIILCSTNSLPDELIATTPKFLEMMVGNSSHCSSINLLRHCIRQELPILAVL 777
                      ::|.::|.|.                    ...|...| ||...:|:....||||
Zfish  1392 ----------ELFQVLLQSQ--------------------EKPHPWRI-LLSEAVRRRCAPLAVL 1425

  Fly   778 AATISEQNRDWCWIVWLSVASGQWSLQLQEASKVRDENRSEWVW-----SVI-RGAVAGGHLNAL 836
            ||:........|..||:..:.....: .|||:...:|:.:..||     |:: :..::...:..|
Zfish  1426 AASHQGSELLQCLCVWILTSVDDDDV-TQEAAAHINESPAHHVWNLHDLSILWKTLLSRSKIRPL 1489

  Fly   837 LHSLEIFHPDCKLTHLCRFLQLTGHQEDFSDA---------TIVELRQFFFSWSQDSVALPLCGP 892
            :...::|..:..|..:.:..:.....:|:..|         :::.||......|.|  .||:
Zfish  1490 IRGFQLFQRESPLIAMLQMYEFCFDYKDYQRAKDKLLDFQKSLLNLRSSSVLSSSD--VLPV--- 1549

  Fly   893 LPRKQLMQRSIGLLLIQLQSNFDCILQQQRFLECICRSDVGDICDLLDFCLLHKVFGVAATWLRE 957
                |.::....:||:.|       |:|.|....:.|                         |.:
Zfish  1550 ----QWVESQASVLLLTL-------LKQSRTQYELRR-------------------------LLQ 1578

  Fly   958 LSIDLEQLGRRDSPEYK----------------------------------RLVDALTEARAYEE 988
            |.:|:|:|.:.:.|:::                                  |:::.|.:|..|.:
Zfish  1579 LLLDVEKLLKSNGPDFRLLSELSQLLCETPVCVSSRLLDCYSPSVLQEECVRIMEELQDAGLYMQ 1643

  Fly   989 ALQLATLLQLPLTDIVYGKWMTELEAGQLRPHEEYEK-----------DIQQHALAPAILVNFLL 1042
            |.::|.|.:||...::..:.:.:|.|.:|:...|.::           .:|...:.|....:|.|
Zfish  1644 ARRVAELAELPAHTLIINQLLRDLSAQKLKRQWERQEIRLAFWRRSHDQLQTEHVQPETACHFFL 1708

  Fly  1043 QAASVVGQ-----VSLRRYELLQSTLGV-IKKHHLFPNESF--DRDQIEYDMVLCYLQ--LPEEQ 1097
            ..|.|..|     |:|:...:|....|: :.:....|:...  |.::.:::   |.:|  |....
Zfish  1709 SQAEVALQSDSELVNLQERCVLLGLAGLWLSRCDPPPSTPILADLEKRQWE---CRIQQRLLLAD 1770

  Fly  1098 LPQLSIYH----SEYFEQIMLQERCVLYKSFSELKELAGIDDLSI------ADKTVLTSEMEDRL 1152
            |.:.|::.    ||...:.:|::     .|||.:..|....:||:      ::..:|..:.:..|
Zfish  1771 LERQSLFAPSALSEDSPENLLRD-----FSFSRMPALNDDANLSLDGLPADSNSCILPDDQQRAL 1830

  Fly  1153 NTLLNTLLDKGDIVEALRLQELFEFRPNDLRFIVFAMALAEGMTSISNLSSKERQLLGEIEKSAF 1217
            .:|:..||:.|.:.||.|:...|.|...|:..::....||.|... ..|.|.:    ||..:|
Zfish  1831 ASLIAQLLNDGSVNEASRVCRYFRFFHRDVWLVLRCRGLACGELQ-PELHSPD----GESRRS-- 1888

  Fly  1218 PKFNRITLNQNVITRWDSDLSDTCSDSVAMEFEEIPSKEKQQTLDTLLGIGSKLKYGVELGRRIV 1282
                               |..:.|.|....|..:.|.:.|..|...| :..:..:|....::::
Zfish  1889 -------------------LPSSPSMSSLSSFVVVSSPDDQLQLQLQL-LVDQCSHGKSYCKQVL 1933

  Fly  1283 LAYRAAMYLDKEYLDVLRTKDTGILLK---SAAAEDCLQRLLVVSDIQISTRMTPKEIAECLA-- 1342
            ..|:.:..|...:.::..::...:|.|   |..:|.|.:....:|    :..:.|..:|..::
Zfish  1934 SLYQLSKELQCSFSELWSSEPECVLQKVLLSRQSERCKKAEAFIS----AQSLQPHTVANLISTA 1994

  Fly  1343 -LELTTCIVR----PRFYIFHAREQPRNALRNADLWGHSIDRDFHLFLELAPNSTMLGNCLLEYC 1402
             ||..|...|    ....||.|.:...:.|:.|.|.|               ::.::||.||:..
Zfish  1995 VLEGLTAHTRDADTSERLIFSASDSRESFLQLAKLCG---------------DANLVGNKLLDSI 2044

  Fly  1403 DALKTYRRYQEGKPFEETEAFENLSKIITLYGLPTPSPTGTMSGIPQVLSHKKQNQIYVELLIKA 1467
            .::                                  |...:|.|             |||||.|
Zfish  2045 GSV----------------------------------PLSDLSCI-------------VELLILA 2062

  Fly  1468 HLCFVHECSMEGIVSVLQKAKAL-NTKLAQAKSWSLIVRLLIGIARYREMFYCFDSLIENEQFES 1531
            |.||...|::||||.|||..:.| :|.||...:..|:||||.||.||.:|.|.||.|.:|.:||.
Zfish  2063 HDCFSVTCNLEGIVRVLQACRHLSHTHLAHGDAHGLLVRLLTGIGRYNDMTYVFDLLHQNHRFEM 2127

  Fly  1532 LLGQFDEDQKGGLRQAILSYLREYQPKNGKELLRLAALHFLMYKELAEMWTTEAQEIVTKI--QA 1594
            ||.:..|... .|:.|:|.|::...| ...|...:.||.|.|.:|:.|.....|:..:..|  |.
Zfish  2128 LLRKKVESNV-RLKTALLDYIKRCLP-GDSEKHNMVALCFSMCREIGENHEAAARTQLKLIESQP 2190

  Fly  1595 FAAQSNKLKCSVEVQTLLQQALENYTHATENYLLDNKLLLAQQSVSRAELMAMQLDLCNKALEKR 1659
            :...:...|..|:|||||:.|.|:|:.       |:.:..|.:.|..|:|:.:||...|:.||.|
Zfish  2191 WVITAELKKALVKVQTLLKDAAESYSK-------DSCVRQAVRCVKLAKLVTLQLHFLNQGLELR 2248

  Fly  1660 HSNNANHLCVSVIGVRSREQFRELVNVHLSVP---QALILSRAYGYDISWSEAILSQFVVLQG-V 1720
                       :|.:    |..:|.|...::|   |..:|:.||.:...|:| :|.|.|:::| .
Zfish  2249 -----------IINL----QHTDLQNTSNTLPHCYQVFVLAEAYDFSPDWAE-VLYQKVIMRGDF 2297

  Fly  1721 NYLQEYLCHQRINDDVIEQIVKGYLLHIQSNATNSKQEESMVQLVGLIKSVVLKYKLASILGFKS 1785
            :||:|:..|:.:...:.:.| ...:.|.:..|:.|   :.:.:|:...:.|...||||....|..
Zfish  2298 SYLEEFKRHRPLAASLFQDI-SNKVCHQKPPASCS---QHLKKLLSHCEDVYTHYKLAYEHQFLD 2358

  Fly  1786 IVMSLINDSSV-YYLRD 1801
            :...|:.||.. .:|:|
Zfish  2359 VANMLLQDSKTNSFLKD 2375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13531	NP_001286748.1	Spatacsin_C	1452..1746	CDD:291322	97/300 (32%)
spg11	NP_001181923.1	Spatacsin_C	2035..2323	CDD:291322	104/360 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5772
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3540
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29578at33208
OrthoFinder	1	1.000	-	-		FOG0006966
OrthoInspector	1	1.000	-	-		oto41485
orthoMCL	1	0.900	-	-		OOG6_107425
Panther	1	1.100	-	-	LDO	PTHR13650
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5803
SonicParanoid	1	1.000	-	-		X5859
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.090