DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13531 and Spg11

DIOPT Version :9

Sequence 1:	NP_001286748.1	Gene:	CG13531 / 37627	FlyBaseID:	FBgn0034786	Length:	1815	Species:	Drosophila melanogaster
Sequence 2:	NP_663506.2	Gene:	Spg11 / 214585	MGIID:	2444989	Length:	2430	Species:	Mus musculus

Alignment Length:	2009	Identity:	461/2009 - (22%)
Similarity:	743/2009 - (36%)	Gaps:	548/2009 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 KIPVSEYRHYFYDVVQAYVQRL--------------LSERLVCKAEDVIRNVDRDVK------CF 93
            :||.::   .|:.:.....|||              |.:..|.:|..::||:...|:      ||
Mouse   693 RIPEAQ---TFFRISGHSAQRLEELVRIGLDLAFDSLKKNNVEEASRLLRNMGFSVEDELLKICF 754

  Fly    94 FFQFACECQDEELSEFVLDHLRSREPLMYEQEEPVLAYHWSLVQQLRECEALVAKH-----RTQ- 152
            :      ..|:.:.:|:::.|:.:|....::...|     ..|.||   |||.:.|     :||
Mouse   755 Y------TTDKNIRDFLVEILKEKECFSEKERRTV-----DFVHQL---EALYSGHFQENAQTQA 805

  Fly   153 LPRVHIEAMMTLPEQA--------------------------------------LQLLLVELYFA 179
            .||..|:.......::                                      |:.|..|.|.|
Mouse   806 FPRYWIKEQDCFKHKSVLDTFLKYDKKDEFHKQDHRIALNWAHRWDLQTQECILLRRLSPEEYKA 870

  Fly   180 NGNESLLGSLSKDMVWQHLVDSDEQAKLQRWCRLQEEGFVSQETLSPLEQSFTAWKIDATMYEYA 244
            ...|:|         |:||....:.:.:..|.    |.|.:|||.||.:..:.....|      .
Mouse   871 RSPEAL---------WRHLTARHDCSSISLWM----EEFQTQETESPQQSKWPPLSAD------I 916

  Fly   245 VEE-----LQQPSEVLRNFFARAGYFFMDESEDIPSLLRRLCTMECLGKHADLLSRQPLAK---- 300
            :|:     ....:|:| :..||:|.|...|.||...||.||..:.  |...|.|..|....
Mouse   917 IEQGTCCHSHMRNEIL-DKLARSGIFLASELEDFERLLLRLSRIG--GVMQDSLPVQSYKSRAGC 978

  Fly   301 --------YLLDRGQYSLL-----LMECVPIASLELLAGTETHQ-EPLINLIVDIK--TNSLTEN 349
                    |.|:.|...||     ..:..| .:...|...|.|: .|.:..:|..:  :::||:.
Mouse   979 DFHSRFILYCLEHGLQHLLYTYLDYYKLSP-GNCPFLEKKELHEAHPWLEFLVQCRQVSSNLTDP 1042

  Fly   350 E-GFELISKSVQAYLEKTHDTVDS--FEGHPLL----TFYDFLG---------QEPSVRSLEGFL 398
            : .|:....:.|..:.....:|.|  .|||.||    |.|...|         .|..::.::..|
Mouse  1043 KLIFQASLANAQILIPTNQASVSSMLLEGHTLLALATTMYAPGGVSQVIQNEDSENCLKKVDPQL 1107

  Fly   399 TSTNLGRVPYLKSLIARFDHGPTSCNFGLPTAH-----------DLFMKFKHVNLPLLATAGHGE 452
            ....|...|.||:.:......|:.....:...|           .||: ::..|...:...| .:
Mouse  1108 LKVALTPYPKLKAALFPQYTAPSILPSDITLYHLIQSLPPFDPSRLFV-WQSANTLAIGDTG-SQ 1170

  Fly   453 LVCFSNARLSQRYARKSQLNYTHYLKQQRSAYAVYYLITEQL-------QLYGQITKTQLFHACE 510
            |..||:..|..:||...:|||.:||...|.::|....:.::|       ||..|:.|       |
Mouse  1171 LPHFSSPDLVSKYAVLERLNYAYYLHHGRPSFAFGTFLVQELIKSKTPKQLIQQVGK-------E 1228

  Fly   511 TVTQIALQHAGDDELVTHCVACCEMLGFDTQPLR---------------------SFL--LLQRK 552
            ..| :.|....:..:...||...|:||..:..||                     ||:  .|..|
Mouse  1229 AYT-LGLSSFTNPSVGAACVCFLELLGLSSLKLRVDLKMANVILGSKRRDEDARSSFIRESLAEK 1292

  Fly   553 LPKCETGQ--SYSELL-----GEWD----RDLVEMLEANPSEFPLELYQSLMRLAIRDTPGKLPM 606
            |.|...|.  :..|||     |.||    :....:...:.|::.|.|...::.      ..||.:
Mouse  1293 LSKLADGDRAATEELLVLLEEGVWDSIEQQGFSRLSSESSSQWALVLQFCMLH------DRKLSV 1351

  Fly   607 DLLKRYASKNNWWHLLLVFQFFDLPLSELKKLLPHFKSSPIGVHLLRALSYESSGDRHHKRTLQR 671
            ..|:..|..|:|...|:..|..:...:|::.||.:|  ||:                     ||.
Mouse  1352 SYLRECAKANDWLQFLVHSQLHNYHPAEVESLLQYF--SPV---------------------LQS 1393

  Fly   672 PTRRSGETQTNSSQETMTNSSHSSNQDSSVQQLQRNTDQSLCTLLTHTARQDVFAIILCSTNSLP 736
            ..:.:.|..::.|         .|..||.:|:||:|..:
Mouse  1394 HLKLASEKLSSGS---------ISRDDSCLQELQKNKGE-------------------------- 1423

  Fly   737 DELIATTPKFLEMMVGNSSHCSSIN-LLRHCIRQELPILAVLAATISEQNRDWCWIVW------- 793
                  |..|.|::...|...:|.: ||...:|...|||:|||:.:...:...|..||
Mouse  1424 ------TSNFFEILHRCSDESTSWSWLLAEAVRHRAPILSVLASCVQGASVVSCLCVWIVTSVED 1482

  Fly   794 -----------LSVASGQWSLQLQEASKVRDENRSEWVWSVIRGAVAGGHLNALLHSLEIFHPDC 847
                       :||....|||:           ....:|   |..:.....:.|:...::|..|.
Mouse  1483 KVAAEAMGHIQISVEDHHWSLK-----------DLSIIW---RTVLTRRKSHTLIRGFQLFIKDS 1533

  Fly   848 KLT------HLCRF--------LQLTGHQEDFSDATIVELRQFFF---SWSQDSVALPLCGPLPR 895
            .|.      .||.|        ::|...|:.......|..|....   ||.:|.|.. |...:|:
Mouse  1534 PLLLIMEMYELCMFFKNYEKAKVKLLEFQKSLETLDTVAARVLPIIPASWMKDQVCF-LLKLMPQ 1597

  Fly   896 KQLMQRSIGLLLIQLQSNFDCILQQQRFLECICRSDVGDICDLLDFCLLHKVF---GVAATWLRE 957
            :...|..:|.|| ||     .:..:|.|      ||..|:..|   |||.:|.   .:|.:....
Mouse  1598 QCETQYELGKLL-QL-----FVGTEQLF------SDGPDVQKL---CLLSQVLKDTPIAISPAVI 1647

  Fly   958 LSIDLEQLGRRDSPEYKRLVDALTEARAYEEALQLATLLQLPLTDIVYGKWMTELEAGQLRP--- 1019
            .|...|...|    |.:.:::.|.....:..|.::|.|..||:..::..:...|::.....|
Mouse  1648 SSYSTENFQR----ECRSILEKLKADGQFAVARRVAELAALPVDSLLIEQLTQEMQTLTHTPQWS 1708

  Fly  1020 ------------HEEYEKDIQQHALAPAILVNFLLQAASV----VGQVSLRRYELLQSTLGVIKK 1068
                        ||.::|:......|.:.   |..||..|    ..|.||....||.:..|
Mouse  1709 LKQERLGFWKKCHEIFKKNSISKRAASSF---FSSQAPEVSEHPAEQGSLEERHLLLTLAG---- 1766

  Fly  1069 HHLFPNESF---DRDQIEYDMVLCYLQ------LPEEQLPQLS---IYHSEYFEQIMLQERCVLY 1121
            |.|...|..   :.:.:|..:.:|.:.      ..||..|.||   :..:|.....:..|
Mouse  1767 HWLAQEEPVPVEELEGLEKQIWICRVAQHTCGGAEEEAKPSLSQHKLAAAELSFDSLASE----- 1826

  Fly  1122 KSFSELKEL-----AGIDDLSIADKTV----LTSEMEDRLNTLLNTLLDKGDIVEALRLQELFEF 1177
            .|||:|..|     .|::||  ..||.    |..:.::.||||:..|||.|.:.||.|:.:.|.|
Mouse  1827 LSFSKLAALNTSKYLGLNDL--PSKTTCENRLKHKEQESLNTLIGQLLDGGCVHEASRVCQYFRF 1889

  Fly  1178 RPNDLRFIVFAMALAEGMTSISNLSSKERQLLG------EIEKSAFPKFNRITLNQNVITRWDSD 1236
            ...||..::...|||....::.:|.|:.|.||.      ::|..:.|            .|....
Mouse  1890 YSQDLVLVLHCRALASAEATMEDLHSEIRALLSSAAQPEDLESPSVP------------LRKAHS 1942

  Fly  1237 LSDTCSDSVAMEFEEIPSKEKQQTLDTLLGIGSKLKYGVELGRRIVLAYRAAMYLDKEYLDVLRT 1301
            .|...|.|..|   ..|:.|..|.|.||:   ||..:|....|:::..|..|..|...|.|| ..
Mouse  1943 SSSLDSQSFVM---VPPTDEVAQNLHTLI---SKCLHGKNYCRQVLCLYELAKDLGCSYGDV-AA 2000

  Fly  1302 KDTGILLKSAAA----EDCLQRLLVVSDIQISTR-MTPKEIAECLALELTTCIVRPRFYIFHARE 1361
            :|:..:|::..|    :.|.|     :.:.|:|: :....:||.:|.|:|..::.|....  ..:
Mouse  2001 RDSEAMLRAILASQRPDRCRQ-----AQVFINTQGLEADTVAELVAEEVTRELLTPSEGT--GEK 2058

  Fly  1362 QPRNALRNADLWGHSIDRDFHLFLELAPNSTMLGNCLLEYCDALKTYRRYQEGKPFEETEAFENL 1426
            ||.|                                                  |.||::.|..|
Mouse  2059 QPFN--------------------------------------------------PAEESQTFLQL 2073

  Fly  1427 SKII---TLYGL----PTPS-PTGTMSGIPQVLSHKKQNQIYVELLIKAHLCFVHECSMEGIVSV 1483
            :.:.   ||.|:    ..|| |.|.:|             ...||||.||.||...|.||||..|
Mouse  2074 TALCQDRTLVGMKLLDKIPSVPHGELS-------------CTTELLILAHHCFTFTCHMEGITRV 2125

  Fly  1484 LQKAKAL-NTKLAQAKSWSLIVRLLIGIARYREMFYCFDSLIENEQFESLLGQFDEDQKGGLRQA 1547
            ||.|:.| :..||..:.:.|:||||.||.||.||.|.||.|.:...||.|:.: ..|..|.|:.|
Mouse  2126 LQAARMLTDNHLAPNEEYGLVVRLLTGIGRYNEMTYIFDLLHQKHYFEVLMRK-KLDPTGTLKTA 2189

  Fly  1548 ILSYLREYQPKNGKELLRLAALHFLMYKELAEMWTTEAQEIVTKIQAFAAQS----NKLKCSVEV 1608
            :|.|::..:| ...|...:.||.|.|.:|:.     |..|....||....:|    ..||...::
Mouse  2190 LLDYIKRCRP-GDSEKHNMIALCFSMCREIG-----ENHEAAACIQLKLIESQPWEESLKDGAQL 2248

  Fly  1609 QTLLQQALENYTHATENYLLDNKLLLAQQSVSRAELMAMQLDLCNKALEKRHSNNANHLCVSVIG 1673
            :.||.:||.....|.|:|..|:.:..|.......:|:.:|:...|        :..|.:.:::
Mouse  2249 KQLLLKALTLMLDAAESYAKDSCVRQALHCNRLTKLITLQIHFLN--------SGQNTMLINL-- 2303

  Fly  1674 VRSREQFRELVNVHLSVP---QALILSRAYGYDISWSEAILSQFVVLQG-VNYLQEYLCHQRIND 1734
                 ..::|::..:::|   ||.|::.||.:...|:| :|.|.|:|:| .:||:|:...:.:..
Mouse  2304 -----GHQKLMDCIMTLPRFYQASIVAEAYDFVPDWAE-VLYQQVILKGDFSYLEEFKQQKLLRP 2362

  Fly  1735 DVIEQIVKGYLLHIQSNATNSKQEESMVQLVGLIKSVVLKYKLASILGFKSIVMSLIND 1793
            ::.|.|.|.|..|    ....:..|::.:|:...:.:.|.||||....|..||..|:.|
Mouse  2363 NIFEDISKKYKQH----QPTDRVTENLKKLLSYCEDIYLYYKLAYEHKFFEIVNMLLKD 2417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13531	NP_001286748.1	Spatacsin_C	1452..1746	CDD:291322	92/302 (30%)
Spg11	NP_663506.2	Spatacsin_C	2082..2374	CDD:291322	99/327 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850161
Domainoid	1	1.000	113	1.000	Domainoid score	I6150
eggNOG	1	0.900	-	-		E1_KOG1884
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3929
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006966
OrthoInspector	1	1.000	-	-		oto92896
orthoMCL	1	0.900	-	-		OOG6_107425
Panther	1	1.100	-	-	LDO	PTHR13650
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5803
SonicParanoid	1	1.000	-	-		X5859
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780