DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RAB15 and ypt2

DIOPT Version :9

Sequence 1:	NP_001295083.1	Gene:	RAB15 / 376267	HGNCID:	20150	Length:	212	Species:	Homo sapiens
Sequence 2:	NP_594580.1	Gene:	ypt2 / 2543280	PomBaseID:	SPAC9E9.07c	Length:	200	Species:	Schizosaccharomyces pombe

Alignment Length:	187	Identity:	97/187 - (51%)
Similarity:	136/187 - (72%)	Gaps:	8/187 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     3 KQYDVLFRLLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIEVDGIKVRIQIWDTAGQ 67
            |.||.|.:|||||||||||:|||.||:::.|..|.|:|||:|||::|||:||.::::||||||||
pombe     4 KSYDYLIKLLLIGDSGVGKSCLLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQ 68

Human    68 ERYQTITKQYYRRAQGIFLVYDISSERSYQHIMKWVSDVDEYAPEGVQKILIGNKADEEQKRQVG 132
            ||::|||..|||.|.||.|:||::.::|:.::..|.|:|:::|.|.|.|||||||.|.|.:|||.
pombe    69 ERFRTITTAYYRGAMGILLLYDVTDKKSFDNVRTWFSNVEQHASENVYKILIGNKCDCEDQRQVS 133

Human   133 REQGQQLAKEYGMDFYETSACTNLNIKESFTRLTELVLQAHRKELEGLRMRASNELA 189
            .||||.||.|.|:.|.|.||.||:|:.|:|..|.        :|::..::.|.||.:
pombe   134 FEQGQALADELGVKFLEASAKTNVNVDEAFFTLA--------REIKKQKIDAENEFS 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAB15	NP_001295083.1	Rab15	9..172	CDD:206698	89/162 (55%)
RAB15	NP_001295083.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..212
ypt2	NP_594580.1	Rab8_Rab10_Rab13_like	7..173	CDD:206659	92/173 (53%)
ypt2	NP_594580.1	Ras	11..172	CDD:278499	90/168 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0078
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810