DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3649 and FEN2

DIOPT Version :9

Sequence 1:	NP_611725.2	Gene:	CG3649 / 37626	FlyBaseID:	FBgn0034785	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_009957.1	Gene:	FEN2 / 850394	SGDID:	S000000623	Length:	512	Species:	Saccharomyces cerevisiae

Alignment Length:	538	Identity:	99/538 - (18%)
Similarity:	168/538 - (31%)	Gaps:	186/538 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VAFTNANSSNPNYPEYRLTEPQK----SYTISSPFWGSCCTQMMSGYLSSRFGAKVLLLTIMLLT 104
            |.||||..|.       :.|..|    ..|:|:       |..|.||:.......::||.:. ..
Yeast    53 VGFTNAYISG-------MKEDLKMVGNDLTVSN-------TVFMIGYIVGMVPNNLMLLCVP-PR 102

  Fly   105 ALLSIATPFALAWG----------GWQLLFWVRFVQGLAMGGMWPCLY--TH--LAKWCPKKEAN 155
            ..||..|   .|||          .::.:..:||.|.|    ...|.:  ||  |..|..:.|..
Yeast   103 IWLSFCT---FAWGLLTLGMYKVTSFKHICAIRFFQAL----FESCTFSGTHFVLGSWYKEDELP 160

  Fly   156 RMGGIMT-TGLDCGTIMGFALSGVLSASPL----------GWPSTFYVPGYLGIVWCLT--FLRY 207
            ....|.| :||     :|...||.:..|..          ||...|.:.      :|:|  ...|
Yeast   161 IRSAIFTGSGL-----VGSMFSGFMQTSIFTHLNGRNGLAGWRWLFIID------FCITLPIAIY 214

  Fly   208 G----ANSPSESKFISLAERKHIQFALEQNQVIRGATP-----------PVP------------- 244
            |    ...|.::..:|........|..::....|...|           .:|
Yeast   215 GFIFFPGLPDQTSAVSKFSMTRYIFNEQELHYARRRLPARDESTRLDWSTIPRVLKRWHWWMFSL 279

  Fly   245 -------------------WLQ----ILTSR---PFIVLAFCKMSQACSFYTLMQQIPRYIHGIF 283
                               |||    .|..|   |..:.|...:|..|| ...|.:|||..|  :
Yeast   280 VWVLGGENLGFASNSTFALWLQNQKYTLAQRNNYPSGIFAVGIVSTLCS-AVYMSKIPRARH--W 341

  Fly   284 HYSIAANALLSALPFVVMLMSSYGFIFLAEYLTRRRDISLPILRKTINS----FATWTPAV---- 340
            |.|:          |:.::|.....:..|:.|..:...|...|.....:    |.:|...:
Yeast   342 HVSV----------FISLVMVIVAVLIRADPLNPKVVFSAQYLGGVAYAGQAVFFSWANIICHAD 396

  Fly   341 ----ALVILSYVSDQNVVGSMFCLIAATAAISGQAIGSSLNHVDLSPNFAGLLFGMSNTLMSAAG 401
                |:|:.|.......|.:.:.::...:              |:.|.|....:.:..|.:| :|
Yeast   397 LQERAIVLASMNMFSGAVNAWWSILFFAS--------------DMVPKFERGCYALLATAIS-SG 446

  Fly   402 VISPIVIGLTVTKESDRSQWRTVFLGISVILFLGNLMYLIFGQMTVQSWNDSPSKETETEASPKP 466
            ::|.::..|.:.:...:.|                :.|:....|..:. :|..:::.|.:..
Yeast   447 IVSVVIRSLQIKENLSKKQ----------------VPYIDANDMPGED-DDDDNQDNENDGD--- 491

  Fly   467 QASAPSVAEETISVERFN 484
                    :|::.||..|
Yeast   492 --------DESMEVELHN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3649	NP_611725.2	MFS	22..442	CDD:119392	92/494 (19%)
CG3649	NP_611725.2	2A0114euk	23..458	CDD:129972	94/510 (18%)
FEN2	NP_009957.1	MFS_FEN2_like	32..450	CDD:340885	88/457 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I2980
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000