DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3649 and dmGlut

DIOPT Version :9

Sequence 1:	NP_611725.2	Gene:	CG3649 / 37626	FlyBaseID:	FBgn0034785	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_620115.2	Gene:	dmGlut / 47253	FlyBaseID:	FBgn0010497	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	144/502 - (28%)
Similarity:	240/502 - (47%)	Gaps:	44/502 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PMWGV---RHL---QVLFLFLCATLIVAQRFNMSVAI-----VAFTNANSSNPNYP--------- 57
            |.||:   |:.   |.:.|.:...|.:...:.|.|.:     |.....||::.:..
  Fly     5 PQWGISLSRYFVIPQRVILAIMGFLAILNAYTMRVCLSQAITVLVVKKNSTDDDSEAICEPDDID 69

  Fly    58 -------EYRLTEPQKSYTISSPFWGSCCTQMMSGYLSSRFGAKVLLLTIMLLTALLSIATPFAL 115
                   ::..:|..:...:||.:.|...|.:..|.|:.:||.|..|...:|.||:.::.||.|:
  Fly    70 EGTSVGGDFEWSEELQGLILSSFYIGYIVTHIPGGLLAEKFGGKWTLGLGILSTAVFTMLTPLAI 134

  Fly   116 AWGGWQLLFWVRFVQGLAMGGMWPCLYTHLAKWCPKKEANRMGGIMTTGLDCGTIMGFALSGVLS 180
            ..|....|...|.:.||..|..:|.|...||.|.|..|..::|.::..|...|||||..||||.
  Fly   135 NKGDSDWLIVTRVLMGLGEGTTFPALSVLLAAWVPANERGKLGALVLGGGQVGTIMGNLLSGVF- 198

  Fly   181 ASPLGWPSTFYVPGYLGIVWCLTFLRYGANSPSESKFISLAERKHIQFALEQNQVIRGA-TPPVP 244
            ....||...||..|.||:||...|:....:.|:...||..:||:::  ..|...:.|.. .||.|
  Fly   199 IDAYGWEFVFYFFGGLGVVWFAIFMFLCYSDPTSHPFIKPSEREYL--VKEIGTISRNEDLPPTP 261

  Fly   245 WLQILTSRPFIVLAFCKMSQACSFYTLMQQIPRYIHGIFHYSIAANALLSALPFVVMLMSSYGFI 309
            |..|||:.|...|...::.....||.::..:|:|:..:..:||.||.|.|:||:|:|.:.|.|..
  Fly   262 WKAILTNLPMFALVAAQIGHDWGFYIMVTDLPKYMADVLQFSIKANGLYSSLPYVMMWIVSVGSG 326

  Fly   310 FLAEYLTRRRDISLPILRKTINSFATWTPAVALVILSYVS-DQNVVGSMFCLIAATAAISGQAIG 373
            |:|:::.||..:|....||.:...|.:.||:.:|..||.. |:.:|..:|.:  ....:.....|
  Fly   327 FVADWMIRRGVLSTTNTRKVMTGLAAFGPAIFMVGASYAGCDRVLVVVLFTI--CMGLMGAYYAG 389

  Fly   374 SSLNHVDLSPNFAGLLFGMSNTLMSAAGVISPIVIGLTVTKESDRSQWRTVF-LGISVILFLGNL 437
            ..|:.:|:|||:||.|..::|.:.:..|||:|.::|: :|..:...:||.|| :...|:.|.. :
  Fly   390 MKLSPLDMSPNYAGTLMAITNGIGAITGVITPYLVGV-MTPNASLLEWRLVFWVAFGVLCFTA-V 452

  Fly   438 MYLIFGQMTVQSWNDSP--SKETETEASPKPQASAPSVAEETISVER 482
            :|.|:....||.:|::|  .:..:.||..:...     .|:|..:|:
  Fly   453 IYCIWASGEVQPFNNAPIQPRSVDFEAQERKVG-----GEKTSGLEQ 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3649	NP_611725.2	MFS	22..442	CDD:119392	129/443 (29%)
CG3649	NP_611725.2	2A0114euk	23..458	CDD:129972	134/460 (29%)
dmGlut	NP_620115.2	2A0114euk	25..463	CDD:129972	129/444 (29%)
dmGlut	NP_620115.2	MFS	77..458	CDD:119392	123/387 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451941
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.890