DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3649 and CG9254

DIOPT Version :9

Sequence 1:	NP_611725.2	Gene:	CG3649 / 37626	FlyBaseID:	FBgn0034785	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_609664.1	Gene:	CG9254 / 34773	FlyBaseID:	FBgn0028513	Length:	481	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	129/484 - (26%)
Similarity:	223/484 - (46%)	Gaps:	43/484 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PMWGV----------RHLQVLFLFLCATLIVAQRFNMSVAI----------VAFTNA-----NSS 52
            |.||:          |.:..:..|.........|..:|.||          :..|.|     :.|
  Fly     8 PEWGIKLSKFFVLPQRWILAIMGFFAIFNAYTMRICLSQAITVLVVKRNYTIFHTEAICEPDDQS 72

  Fly    53 NPNYP----EYRLTEPQKSYTISSPFWGSCCTQMMSGYLSSRFGAKVLLLTIMLLTALLSIATPF 113
            :|:..    :|..::.::...::|.:.|...|.:..|.|:.:||.|..|...:..||:.::.||.
  Fly    73 DPSSTFEGGDYDWSQEKQGLILASFYIGYIVTHLPGGILADKFGGKWTLSLGIFFTAIFTLLTPV 137

  Fly   114 ALAWGGWQLLFWVRFVQGLAMGGMWPCLYTHLAKWCPKKEANRMGGIMTTGLDCGTIMGFALSGV 178
            .:.:||...|..:|.:.||..|..:|.|...||.|.|..|...:|.::..|...|:|.|..:||.
  Fly   138 CIVYGGADALIVLRVLMGLGEGTTFPALSVLLASWVPANERGMLGALVLGGGQMGSIAGNIISGY 202

  Fly   179 LSASPLGWPSTFYVPGYLGIVWCLTFLRYGANSPSESKFISLAERKHIQFAL---EQNQVIRGAT 240
            :.:| :.||..|||...:.:||.:.|.....:||....:|...||..:...:   ::|:
  Fly   203 VLSS-MDWPWVFYVFAIIALVWFVVFTLVCFSSPFTHPYIKPEERAFLAQEVPPPDKNK------ 260

  Fly   241 PPVPWLQILTSRPFIVLAFCKMSQACSFYTLMQQIPRYIHGIFHYSIAANALLSALPFVVMLMSS 305
            |..|:..||||.|...|...::.....||.::..:|:|:..:..:||.:|.|.|:||:|.|.:.|
  Fly   261 PKTPFFAILTSIPMWALISAQIGHDWGFYIMVSYLPKYMSDVLRFSIKSNGLYSSLPYVTMWIMS 325

  Fly   306 YGFIFLAEYLTRRRDISLPILRKTINSFATWTPAVALVILSYVSDQNVVGSMFCLIAATAAISG- 369
            .....:|:.:.:|..:|....||.:...|.:.|||.:|..||.....  |.:..|...|..:.|
  Fly   326 LLSGCVADQMIKRNCMSTTNTRKIMTGVAAFGPAVFMVAASYAGCNR--GMVVALFTITMGLMGT 388

  Fly   370 QAIGSSLNHVDLSPNFAGLLFGMSNTLMSAAGVISPIVIGLTVTKESDRSQWRTVFLGISVILFL 434
            ...|..|..:|:|||:||.|..::|.:.:..||:||.::|: :|..:...:||.||.....:|.:
  Fly   389 YYAGMKLTPLDMSPNYAGTLMAITNGIGAITGVVSPYLVGV-MTPNATLLEWRLVFWVAFGVLVV 452

  Fly   435 GNLMYLIFGQMTVQSWNDSPSKETETEAS 463
            ..::|.|:....||.:||..:...:.:|:
  Fly   453 TAIVYCIWASGDVQPFNDGTNSNKKKDAA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3649	NP_611725.2	MFS	22..442	CDD:119392	119/442 (27%)
CG3649	NP_611725.2	2A0114euk	23..458	CDD:129972	124/457 (27%)
CG9254	NP_609664.1	2A0114euk	28..466	CDD:129972	120/447 (27%)
CG9254	NP_609664.1	MFS	82..461	CDD:119392	111/388 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451940
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.890