DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3649 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_611725.2	Gene:	CG3649 / 37626	FlyBaseID:	FBgn0034785	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	136/454 - (29%)
Similarity:	226/454 - (49%)	Gaps:	26/454 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RFNMSVAIVAFTNANSS--NPNYPEYRLT----EPQKSYTI-SSPFWGSCCTQMMSGYLSSRFGA 93
            |.|:.||||...| ||:  ....||.:..    :|:....| .|.|||...||:..|::|::|.|
  Rat    93 RCNLGVAIVEMVN-NSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAA 156

  Fly    94 KVLLLTIMLLTALLSIATPFALAWGGWQLLFWVRFVQGLAMGGMWPCLYTHLAKWCPKKEANRMG 158
            ..:....:.||:.|::..|.| |...:..:..||.:|||..|..:|..:...:||.|..|.:|:.
  Rat   157 NRVFGAAIFLTSTLNMFIPSA-ARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLA 220

  Fly   159 GIMTTGLDCGTIMGFALSGVLSASPLGWPSTFYVPGYLGIVWCLTFLRYGANSPSESKFISLAER 223
            .....|...|.::...|:||| ...:||.|.||:.|..||:|.:.:|......|:....||..||
  Rat   221 TTSFCGSYAGAVVAMPLAGVL-VQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEER 284

  Fly   224 KHIQFALEQNQVIRGATP-PVPWLQILTSRP---FIVLAFCKMSQACSFYTLMQQIPRYIHGIFH 284
            .:|:.::.:...:...:. ..||.:..||.|   .||..||:   :.:||.|:...|.|...:|.
  Rat   285 TYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCR---SWTFYLLLISQPAYFEEVFG 346

  Fly   285 YSIAANALLSALPFVVMLMSSYGFIFLAEYLTRRRDISLPILRKTINSFATWTPAVALVILSYVS 349
            ::|:...||||:|.:||.:.......||:||..|:.::...:||.:|.......|..|:::.:..
  Rat   347 FAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSH 411

  Fly   350 DQNVVGSMFCLIAATAAISGQAI-GSSLNHVDLSPNFAGLLFGMSNTLMSAAGVISPIVIGLTVT 413
            .:.|..|...|   ....||.|| |.::||:|::|.:|.:|.|:||.:.:.:|::.|:::| .:|
  Rat   412 TKGVAISFLVL---AVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVG-AMT 472

  Fly   414 KESDRSQWRTVFLGISVILFLGNLMYLIFGQMTVQSWNDSPSKETETEASPKPQASAPSVAEET 477
            |...|.:|:.|||..:::.:.|.:.|.:|.....|.|.| |...:|.:.....|   ..:||||
  Rat   473 KHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWAD-PENLSEEKCGIIDQ---DELAEET 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3649	NP_611725.2	MFS	22..442	CDD:119392	125/417 (30%)
CG3649	NP_611725.2	2A0114euk	23..458	CDD:129972	130/433 (30%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	125/418 (30%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750