DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3649 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_611725.2	Gene:	CG3649 / 37626	FlyBaseID:	FBgn0034785	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	465	Identity:	137/465 - (29%)
Similarity:	229/465 - (49%)	Gaps:	41/465 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RFNMSVAIVAFTNANSS--NPNYPEYRLT----EPQKSYTI-SSPFWGSCCTQMMSGYLSSRFGA 93
            |.|:.||||...| ||:  ....||.:..    :|:....| .|.|||...||:..|::|::|.|
Human    93 RCNLGVAIVEMVN-NSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAA 156

  Fly    94 KVLLLTIMLLTALLSIATPFALAWGGWQLLFWVRFVQGLAMGGMWPCLYTHLAKWCPKKEANRMG 158
            ..:....:.||:.|::..|.| |...:..:..||.:|||..|..:|..:...:||.|..|.:|:.
Human   157 NRVFGAAIFLTSTLNMFIPSA-ARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLA 220

  Fly   159 GIMTTGLDCGTIMGFALSGVLSASPLGWPSTFYVPGYLGIVWCLTFLRYGANSPSESKFISLAER 223
            .....|...|.::...|:||| ...:||.|.||:.|..||:|.:.:|......|:....||..|:
Human   221 TTSFCGSYAGAVVAMPLAGVL-VQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEK 284

  Fly   224 KHIQFAL-EQNQVIRGATPPVPWLQILTSRP---FIVLAFCKMSQACSFYTLMQQIPRYIHGIFH 284
            .:|:.:: |...|:..:....||.:..||.|   .||..||:   :.:||.|:...|.|...:|.
Human   285 TYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCR---SWTFYLLLISQPAYFEEVFG 346

  Fly   285 YSIAANALLSALPFVVMLMSSYGFIFLAEYLTRRRDISLPILRKTINSFATWTPAVALVILSYVS 349
            ::|:...||||:|.:||.:.......||:||..|:.::...:||.:|.......|..|:::.:..
Human   347 FAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLVVGFSH 411

  Fly   350 DQNVVGSMFCLIAATAAISGQAI-GSSLNHVDLSPNFAGLLFGMSNTLMSAAGVISPIVIGLTVT 413
            .:.|..|...|   ....||.|| |.::||:|::|.:|.:|.|:||.:.:.:|::.|:::| .:|
Human   412 TKGVAISFLVL---AVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVG-AMT 472

  Fly   414 KESDRSQWRTVFLGISVILFLGNLMYLIFGQMTVQSWND--SPSKET-----------------E 459
            :...|.:|:.|||..:::.:.|.:.|.:|.....|.|.|  :.|:|.                 |
Human   473 RHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEIELNHE 537

  Fly   460 TEASPKPQAS 469
            :.||||.:.|
Human   538 SFASPKKKMS 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3649	NP_611725.2	MFS	22..442	CDD:119392	125/417 (30%)
CG3649	NP_611725.2	2A0114euk	23..458	CDD:129972	130/435 (30%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	129/429 (30%)
		MFS	80..502	CDD:119392	125/418 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148614
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750