DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3649 and slc-17.7

DIOPT Version :9

Sequence 1:	NP_611725.2	Gene:	CG3649 / 37626	FlyBaseID:	FBgn0034785	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_505399.1	Gene:	slc-17.7 / 179308	WormBaseID:	WBGene00022788	Length:	506	Species:	Caenorhabditis elegans

Alignment Length:	484	Identity:	118/484 - (24%)
Similarity:	209/484 - (43%)	Gaps:	51/484 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MWGVRHLQ---VLFLFLCATLIVAQRFNMSVAIVAFTNA--------------NSSNPNYPEYRL 61
            :|.:|.::   |:.:.|..|:....|.|:::|||...|:              .|..|..|...|
Worm     7 LWSLRSVRLRVVIAIALALTIEGLMRSNLNMAIVCMLNSTALTDGKPMIASLNTSIEPATPLCPL 71

  Fly    62 TEPQKSYTI---SSPFW--------------GSCCTQMMSGYLSSRFGAKVLLLTIMLLTALLSI 109
            .:..:|..:   .:.||              |.....:.|..|:...||...:|...:...:.:.
Worm    72 LQFGESKVVEHKGTIFWTSQDRAIIFAAFYAGGLVATLASEVLNRYIGATRSVLYGGIANVVGTF 136

  Fly   110 ATPFALA---WGGWQLLFWVRFVQGLAMGGMWPCLYTHLAKWCPKKEANRMGGIMTTGLDCGTIM 171
            .|||..:   :|.:.::. :|||.|...|.:|||:...:|:|.|..|.:....|.|||.....::
Worm   137 LTPFVASQTNFGTFPIIL-LRFVMGFGQGVLWPCMLVLIAQWFPVNEKSTALAIATTGNQLSVVI 200

  Fly   172 GFALSGVLSASPLGWPSTFYVPGYLGIVWCLTFLRYGANSPSES-KFISLAERKHIQFALEQNQV 235
            ....:..|...|.|||..|:|....|||.|:.:.....:||..: |.:|   |..:.:...:...
Worm   201 AMFATAELCQLPWGWPMAFHVYAVCGIVMCIIWYMMVYDSPCHADKKLS---RDELHYITTERVR 262

  Fly   236 IRGATPPVPWLQILTSRPFIVLAFCKMSQACSFYTL--MQQIPRYIHGIFHYSIAANALLSALPF 298
            :|...|  .|:.::.|.  :|.|....|.|.::.|:  :..:|.|...:.:.|:.:|.|.|||||
Worm   263 LRPQHP--NWMALMKSP--VVWAIAASSFAHNYVTVGTITYLPLYYKTVLNMSLTSNGLWSALPF 323

  Fly   299 VVMLMSSYGFIFLAEYLTRRRDIS-LPILRKTINSFATWTPAVALVILSYVSDQNVVGSMFCLIA 362
            |:.|:|...:..:|| ..|:||.| :..:.|..||.|::..|:...:|..........::|.:..
Worm   324 VLQLISKVFYAGMAE-SARKRDWSDINRITKFCNSSASFGIAICFGLLCLCDCSQRGAAIFLICL 387

  Fly   363 ATAAISGQAIGSSLNHVDLSPNFAGLLFGMSNTLMSAAGVISPIVIGLTVTKESDRSQWRTVFLG 427
            |...:||...|.:.:.|.::|.....:...|......|..::|..|| ..||:....:|:.||..
Worm   388 AMCFVSGYIPGYNTSAVTIAPGQTAAIAAFSRFWGQIASSVAPYHIG-AYTKQGTADEWKIVFAV 451

  Fly   428 ISVILFLGNLMYLIFGQMTVQSWNDSPSK 456
            |:.|..:..:.:...|..::|.|:.:.||
Worm   452 IAAICVVTGIFFQCCGTASLQDWDSTHSK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3649	NP_611725.2	MFS	22..442	CDD:119392	111/457 (24%)
CG3649	NP_611725.2	2A0114euk	23..458	CDD:129972	115/472 (24%)
slc-17.7	NP_505399.1	MFS	31..467	CDD:391944	108/445 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28615
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930