DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9826 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_611724.1	Gene:	CG9826 / 37625	FlyBaseID:	FBgn0034784	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_892004.1	Gene:	Slc17a8 / 216227	MGIID:	3039629	Length:	601	Species:	Mus musculus

Alignment Length:	488	Identity:	142/488 - (29%)
Similarity:	239/488 - (48%)	Gaps:	34/488 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CKGPRLGVRHLQSFLLFLGLTVMHIARLNVSVAIVAMTNAATT----NPNF--PEFEWTEKQKSY 64
            |..|:   |::.:.:..||..:....|.|:.||||.|.|.:|.    .|..  .:|.|..:....
Mouse    83 CGIPK---RYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGL 144

  Fly    65 ILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTP-------WCITWGGWQVFCAI 122
            |..||:||||:|..||.|:..::.|..|...|...|:.|::..|       .|:        ..:
Mouse   145 IHGSFFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCV--------MGV 201

  Fly   123 RILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAKGAMGWPGISY 187
            ||||||.:||.:|......:.|:||.||:||...|:.|:..|.|:||.::|::.: .:||..:.|
Mouse   202 RILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ-YIGWASVFY 265

  Fly   188 VSGSLCAAWCFLWLIFASNNATESRFVGEAECKYIESSLEHNEDFHGRT-IPIPWRAIWTSVPFL 251
            :.|.....|...||:.|.........:..||..|||:|:....:....: ...|||..:||:|..
Mouse   266 IYGMFGIIWYMFWLLQAYECPAAHPTISNAERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVY 330

  Fly   252 ALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKI 316
            |::|.....::....|....|:|...|....|....:.|::|.:.|.::..:....||.|..:||
Mouse   331 AIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKI 395

  Fly   317 LSLTAVRKLFNTLSFWIPAAALIGIGFLSEENKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNH 381
            |:.|||||:.|...|.:.|..|:.:||  ...|.:||..:.::||.:..|..|.::|.:|::|.:
Mouse   396 LTTTAVRKIMNCGGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRY 458

  Fly   382 AGILIGLSNTVANVIPILTPLIAGEIVADKHNRGQWQIVFGLAAVIFFVGNVVFIIWGTAKAQPW 446
            |.||:|:||.|..:..::.|||.|.:...| .|.:||.||.:||::.:.|.:.:.::.:.:.|.|
Mouse   459 ASILMGISNGVGTLSGMVCPLIVGAMTKHK-TREEWQNVFLIAALVHYSGVIFYGVFASGEKQDW 522

  Fly   447 -DADDFLKPK----DTESACEKPKITPAEVAPP 474
             |.::..:.|    |.:...|:.::.......|
Mouse   523 ADPENLSEDKCGIIDQDELAEETELNHETFVSP 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9826	NP_611724.1	2A0114euk	14..450	CDD:129972	136/450 (30%)
CG9826	NP_611724.1	MFS	19..438	CDD:119392	132/432 (31%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	136/449 (30%)
		MFS	93..515	CDD:119392	132/433 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11710
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910