DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9825 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_611723.3	Gene:	CG9825 / 37624	FlyBaseID:	FBgn0034783	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	141/474 - (29%)
Similarity:	223/474 - (47%)	Gaps:	26/474 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RHVQALLIFLNITTVFIGRLNVGVSVVAMTNAETT----NPNF--PEYDWTEAEKSYILSSFFWG 72
            |::.|::..|.....|..|.|:||::|.|.|..|.    .|..  .:::|.......|..|||||
  Rat    75 RYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWG 139

  Fly    73 YILTQFLGGYLCKRFGVKSVMFWGVFGSGVCSALTPLFIGFGEWQAYCGIRVLMGLAQGVVFPCI 137
            ||:||..||::..:|....|....:|.:...:...|...........| :|:|.||.:||.:|..
  Rat   140 YIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMC-VRILQGLVEGVTYPAC 203

  Fly   138 HQHLAKWSPPEERNRLGALSHTGIECGNVSAMFLSGMIAKSSLGWPGISYVSAGVAFFWCTLWFV 202
            |...:||:||.||:||...|..|...|.|.||.|:|::.: .:||..:.|:.......|...|.:
  Rat   204 HGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ-YIGWASVFYIYGMFGIIWYMFWLL 267

  Fly   203 FA----ANHPTESRFIGENELIYIESSLKHNESYHA-TIIPIPWKAIWTSAPFLALLIVRCAENW 262
            .|    |.|||    |...|..|||:|:....:..: :....||:..:||.|..|:::.....:|
  Rat   268 QAYECPAVHPT----ISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSW 328

  Fly   263 GLSTLQAEIPSYMNGVLDMDMKSNAFFSALPFLAMWCMSYIYLVVADVLLGKNSVSLTILRKTYN 327
            ....|....|:|...|....:......||:|.:.|..:..|...:||.|..:..::.|.:||..|
  Rat   329 TFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMN 393

  Fly   328 SIAFWIPAATLVGIGFLDKEQKNFAIALMTISVGVNSAQTIGSVLNTIDLSKNHASILMGIVNTA 392
            ...|.:.|..|:.:||  ...|..||:.:.::||.:.....|..:|.:|::..:|||||||.|..
  Rat   394 CGGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGV 456

  Fly   393 ANFVPIVTPLVVGWIVKENSDRSQWQIVFIIASVIFFVGNCIYLVFGTAETQPW-DAEDYLQTQ- 455
            .....:|.||:||.:.|..: |.:||.||:||:::.:.|...|.||.:.|.|.| |.|:..:.:
  Rat   457 GTLSGMVCPLIVGAMTKHKT-REEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEEKC 520

  Fly   456 ----NPELANRPPMQALSF 470
                ..|||....:...:|
  Rat   521 GIIDQDELAEETELNHEAF 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9825	NP_611723.3	2A0114euk	14..450	CDD:129972	136/447 (30%)
CG9825	NP_611723.3	MFS	54..438	CDD:119392	117/388 (30%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	130/431 (30%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342508
Domainoid	1	1.000	47	1.000	Domainoid score	I11657
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750