DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9825 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_611723.3	Gene:	CG9825 / 37624	FlyBaseID:	FBgn0034783	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	492	Identity:	146/492 - (29%)
Similarity:	231/492 - (46%)	Gaps:	37/492 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LGMRHVQALLIFLNITTVFIGRLNVGVSVVAMTNAETT----NPNF--PEYDWTEAEKSYILSSF 69
            |..|::.|::..|.....|..|.|:||::|.|.|..|.    .|..  .:::|.......|..||
Human    72 LPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSF 136

  Fly    70 FWGYILTQFLGGYLCKRFGVKSVMFWGVFGSGVCSALTPLFIGFGEWQAYCGIRVLMGLAQGVVF 134
            |||||:||..||::..:|....|....:|.:...:...|...........| :|:|.||.:||.:
Human   137 FWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMC-VRILQGLVEGVTY 200

  Fly   135 PCIHQHLAKWSPPEERNRLGALSHTGIECGNVSAMFLSGMIAKSSLGWPGISYVSAGVAFFWCTL 199
            |..|...:||:||.||:||...|..|...|.|.||.|:|::.: .:||..:.|:.......|...
Human   201 PACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ-YIGWSSVFYIYGMFGIIWYMF 264

  Fly   200 WFVFA----ANHPTESRFIGENELIYIESSLKHNESYHATIIPI-----PWKAIWTSAPFLALLI 255
            |.:.|    |.|||    |...|..|||:|:...    |.::.:     |||..:||.|..|:::
Human   265 WLLQAYECPAAHPT----ISNEEKTYIETSIGEG----ANVVSLSKFSTPWKRFFTSLPVYAIIV 321

  Fly   256 VRCAENWGLSTLQAEIPSYMNGVLDMDMKSNAFFSALPFLAMWCMSYIYLVVADVLLGKNSVSLT 320
            .....:|....|....|:|...|....:......||:|.:.|..:..|...:||.|..:..::.|
Human   322 ANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTT 386

  Fly   321 ILRKTYNSIAFWIPAATLVGIGFLDKEQKNFAIALMTISVGVNSAQTIGSVLNTIDLSKNHASIL 385
            .:||..|...|.:.|..|:.:||  ...|..||:.:.::||.:.....|..:|.:|::..:||||
Human   387 AVRKIMNCGGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASIL 449

  Fly   386 MGIVNTAANFVPIVTPLVVGWIVKENSDRSQWQIVFIIASVIFFVGNCIYLVFGTAETQPW-DAE 449
            |||.|.......:|.||:||.:.:..: |.:||.||:||:::.:.|...|.||.:.|.|.| |.|
Human   450 MGISNGVGTLSGMVCPLIVGAMTRHKT-REEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPE 513

  Fly   450 DYLQTQ-----NPELANRPPMQALSFPINENSKEKIN 481
            :..:.:     ..|||....:...||   .:.|:|::
Human   514 NLSEEKCGIIDQDELAEEIELNHESF---ASPKKKMS 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9825	NP_611723.3	2A0114euk	14..450	CDD:129972	137/451 (30%)
CG9825	NP_611723.3	MFS	54..438	CDD:119392	118/392 (30%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	137/450 (30%)
		MFS	80..502	CDD:119392	130/434 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148613
Domainoid	1	1.000	49	1.000	Domainoid score	I11776
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750