DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9825 and SLC17A4

DIOPT Version :9

Sequence 1:	NP_611723.3	Gene:	CG9825 / 37624	FlyBaseID:	FBgn0034783	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_005486.1	Gene:	SLC17A4 / 10050	HGNCID:	10932	Length:	497	Species:	Homo sapiens

Alignment Length:	479	Identity:	124/479 - (25%)
Similarity:	229/479 - (47%)	Gaps:	46/479 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ETNKGPVLGMRHVQALLIFLNITTVFIGRLNVGVSVVAMT---------NAETTNPN-------- 51
            |.::.....:||..||::.|...:::..::|:.:::.||.         ||.|..|:
Human    26 ECSRKGFCSVRHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGYWN 90

  Fly    52 ---------FPEYDWTEAEKSYILSSFFWGYILTQFLGGYLCKRFGVKSVMFWGVFGSGVCSALT 107
                     .|.|||:...:..||||..:|..|.....||:...||.|.|:..|:|.|...:...
Human    91 ETLKEFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFI 155

  Fly   108 PLFIGFGEWQAYCGI------RVLMGLAQGVVFPCIHQHLAKWSPPEERNRLGALSHTGIECGNV 166
            ||       .|..|:      |::.|:||.:|....:....||:||.||::|..::.:|...|:.
Human   156 PL-------AANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSF 213

  Fly   167 SAMFLSGMIAKSSLGWPGISYVSAGVAFFWCTLWFVFAANHPTESRFIGENELIYIESSLKHNES 231
            ..:...|::.: ::|||.:.|:..|:....|.|||....:.|....||...|..||..||...:.
Human   214 IVLLAGGLLCQ-TIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVCSLAQQDC 277

  Fly   232 YHATIIPIPWKAIWTSAPFLALLIVRCAENWGLSTLQAEIPSYMNGVLDMDMKSNAFFSALPFLA 296
            .....:||  :|:..|.|..|:|:....|.|...|:.|..|:|::.||..:::.:...|||||:
Human   278 SPGWSLPI--RAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFV- 339

  Fly   297 MWCMSYIY-LVVADVLLGKNSVSLTILRKTYNSIAFWIPAATLVGIGFLDKEQKNFAIALMTISV 360
            :.|:..|. .::||.||.:..:.|..:||.:.:|....|:..||.:.:: :...:..:..:.:|.
Human   340 VGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWV-RSSHSMTMTFLVLSS 403

  Fly   361 GVNSAQTIGSVLNTIDLSKNHASILMGIVNTAANFVPIVTPLVVGWIVKENSDRSQWQIVFIIAS 425
            .::|....|:::|.:|::..:...|.|::...|:....::|...|:.:.::|:.. |:.||::::
Human   404 AISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFG-WRNVFLLSA 467

  Fly   426 VIFFVGNCIYLVFGTAETQPWDAE 449
            .:...|...||:||.|:.|.|..|
Human   468 AVNISGLVFYLIFGRADVQDWAKE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9825	NP_611723.3	2A0114euk	14..450	CDD:129972	123/469 (26%)
CG9825	NP_611723.3	MFS	54..438	CDD:119392	104/390 (27%)
SLC17A4	NP_005486.1	UhpC	30..491	CDD:332119	122/473 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740