DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12490 and slc17a5

DIOPT Version :9

Sequence 1:	NP_611722.2	Gene:	CG12490 / 37623	FlyBaseID:	FBgn0034782	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001070195.1	Gene:	slc17a5 / 767760	ZFINID:	ZDB-GENE-060929-1158	Length:	488	Species:	Danio rerio

Alignment Length:	471	Identity:	148/471 - (31%)
Similarity:	238/471 - (50%)	Gaps:	39/471 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TAETNKGPVLGMRHVQALLIFLNITTVFIG---RLNVGVSVVAM----TNAETTNP-----NFP- 53
            |.:..|.|..|.....  |.||:....|:.   |:|:.|::|.|    :.|.|::.     |.|
Zfish    23 TEDIQKAPACGSSRYG--LAFLSCYGFFVAYALRVNLSVAMVDMLKNSSKANTSSSICPPHNIPV 85

  Fly    54 --------EYDWTEAEKSYIFSSFFWGYILTQFIGGYLCKRFGVKSVMFWGVFVSGVCSALTPLF 110
                    .|||....:.:|..|||:|||:||..||||.:::|.|.::..|:..:.:.:.||||.
Zfish    86 PKHNHTAMVYDWNSETQGWILGSFFYGYIITQIPGGYLARKYGAKWLLGLGILCTVIFTLLTPLA 150

  Fly   111 IGFG-GWQAYCGIRVVMGLAQGLVFPCIHHHLAKWSPPAERNRLGALSHTGMECGNVSAMFLSGM 174
            ...| |:  ...:||:.|:.:|:.:|.:|...|.|:||.||:||..:|:||.:.|.|.|:.|||.
Zfish   151 ADLGAGY--LIAVRVLEGIGEGVTYPAMHAMWASWAPPLERSRLLTISYTGAQLGTVVALPLSGQ 213

  Fly   175 IAKSAIGWPGISYVSAGLAFAWCAIWFVFAADNAVESRYITQEELHYIESSLKH----NEDYHKT 235
            |. ..:.|..:.|:...:...|..:|..|.:::....:.||:.|..||.||||:    .:||
Zfish   214 IC-FYLDWTYVFYIFGAVGLLWFFLWICFVSNSPSSHKRITEAEKTYIMSSLKNELSPTQDY--- 274

  Fly   236 VIPVPWMAIWTSAPFLALTLTRCCATWGLSTLQAQIPTYMNGVLDMDMKSNAFFSALPFLAMWIM 300
               :||.:|:.|.|..|:.:......|...||...:|||||.||...::.|...||||:|..|::
Zfish   275 ---IPWTSIFKSMPLWAIVVAHFSYNWTFYTLLTLLPTYMNDVLGFSIQQNGMLSALPYLGCWLL 336

  Fly   301 SYVYLIIADVLLAGNRLSLTALRKTFNSLAFWIPCATLIGIGFLDQEQKNLAIALMTISVGVNSG 365
            :.:...:||:|..........:||.|..:....|...|:..|:..... .||:|.:|||..:...
Zfish   337 ALLGGQLADLLRERFLFRTVIVRKAFTVVGMAGPAVFLVAAGYTGCNY-ILAVAFLTISSSLGGI 400

  Fly   366 ATIGSSLNTIDLSPNHASILMGILNTAVTVVPIVTPLIVGVIVHEDDNRAEWQIVFIIAAVLFFV 430
            :..|.::|.:|::|::|.||:||.|:..|:..:|.|:|...:. :.:...||||||.|:|.:...
Zfish   401 SASGFNINHLDIAPSYAGILLGITNSFATIPGMVGPVIARSLT-KSNTIPEWQIVFYISAAINIF 464

  Fly   431 GNSVYLYFGTAVSQPW 446
            |...:..||....|||
Zfish   465 GAVFFTIFGKGTVQPW 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12490	NP_611722.2	2A0114euk	14..450	CDD:129972	144/459 (31%)
CG12490	NP_611722.2	MFS	54..438	CDD:119392	126/388 (32%)
slc17a5	NP_001070195.1	2A0114euk	27..488	CDD:129972	147/467 (31%)
slc17a5	NP_001070195.1	MFS	92..472	CDD:119392	126/390 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D619250at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850