DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12490 and slc17a8

DIOPT Version :9

Sequence 1:	NP_611722.2	Gene:	CG12490 / 37623	FlyBaseID:	FBgn0034782	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001076304.1	Gene:	slc17a8 / 563467	ZFINID:	ZDB-GENE-060503-416	Length:	590	Species:	Danio rerio

Alignment Length:	457	Identity:	141/457 - (30%)
Similarity:	224/457 - (49%)	Gaps:	30/457 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LGMRHVQALLIFLNITTVFIGRLNVGVSVVAMTNAETTNPNF------PEYDWTEAEKSYIFSSF 69
            |..|::.|:|..|.....|..|.|:||::|.|.|..|...|.      .:::|.......|..||
Zfish    72 LPKRYIIAMLSGLGFCISFGIRCNLGVAIVEMVNNNTVYINGTAVMQPAQFNWDPETVGLIHGSF 136

  Fly    70 FWGYILTQFIGGYLCKRFGVKSVMFWGVFVSGVCSALTPLFIGFGGWQAYCG----IRVVMGLAQ 130
            |||||:||..||::..:.....|....:|::.|.:...|     ...:.:.|    :|::.||.:
Zfish   137 FWGYIVTQIPGGFISNKLAANRVFGAAIFLTSVLNMFIP-----SAARVHYGCVMFVRILQGLVE 196

  Fly   131 GLVFPCIHHHLAKWSPPAERNRLGALSHTGMECGNVSAMFLSGMIAKSAIGWPGISYVSAGLAFA 195
            |:.:|..|...:||:||.||:||...|..|...|.|.||.|:|::.: .:|||.:.|:.......
Zfish   197 GVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQ-YVGWPSVFYIYGVFGII 260

  Fly   196 WCAIWFVFAADNAVESRYITQEELHYIESS------LKHNEDYHKTVIPVPWMAIWTSAPFLALT 254
            |...|.:.|.::......|::||.:|||:|      |..:.:..||    ||...:||.|..|:.
Zfish   261 WYIFWILLAYNSPAVHPTISEEERNYIETSIGEGANLMSSTEKFKT----PWREFFTSMPVYAII 321

  Fly   255 LTRCCATWGLSTLQAQIPTYMNGVLDMDMKSNAFFSALPFLAMWIMSYVYLIIADVLLAGNRLSL 319
            :...|.:|....|....|.|...|....:......||:|.:.|.|:..:...:||.|.:...||.
Zfish   322 VANFCRSWTFYLLLISQPAYFEEVFGFPISKVGILSAVPHMVMTIIVPIGGQLADFLRSRKILST 386

  Fly   320 TALRKTFNSLAFWIPCATLIGIGFLDQEQKNLAIALMTISVGVNSGATIGSSLNTIDLSPNHASI 384
            |.:||..|...|.:....|:.:||  ...:.:||:.:.::||.:..|..|.::|.:|::|.:|||
Zfish   387 TTVRKIMNCGGFGMEATLLLVVGF--SHTRAVAISFLILAVGFSGFAISGFNVNHLDIAPRYASI 449

  Fly   385 LMGILNTAVTVVPIVTPLIVGVIVHEDDNRAEWQIVFIIAAVLFFVGNSVYLYFGTAVSQPW-DA 448
            ||||.|...|:..:|.|||||.:. :...|.|||.||:||:::.:.|...|..|.:...|.| |.
Zfish   450 LMGISNGVGTLSGMVCPLIVGALT-KHKTRLEWQHVFVIASMVHYTGVIFYAIFASGEKQDWADP 513

  Fly   449 ED 450
            |:
Zfish   514 EN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12490	NP_611722.2	2A0114euk	14..450	CDD:129972	139/452 (31%)
CG12490	NP_611722.2	MFS	54..438	CDD:119392	121/393 (31%)
slc17a8	NP_001076304.1	2A0114euk	75..514	CDD:129972	139/451 (31%)
		MFS	81..503	CDD:119392	133/434 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582532
Domainoid	1	1.000	42	1.000	Domainoid score	I12425
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740