DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12490 and Slc17a5

DIOPT Version :9

Sequence 1:	NP_611722.2	Gene:	CG12490 / 37623	FlyBaseID:	FBgn0034782	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_766361.1	Gene:	Slc17a5 / 235504	MGIID:	1924105	Length:	495	Species:	Mus musculus

Alignment Length:	470	Identity:	142/470 - (30%)
Similarity:	227/470 - (48%)	Gaps:	29/470 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ETNKGPV-LGMRHVQALLIFLNITTVFIGRLNVGVSVVAMTNAETT------------------- 48
            :|...|| ...|:..|:|.|.....::..|:|:.|::|.|.::.||
Mouse    28 QTEAAPVCCSARYNLAILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKV 92

  Fly    49 --NPNFPEYDWTEAEKSYIFSSFFWGYILTQFIGGYLCKRFGVKSVMFWGVFVSGVCSALTPLFI 111
              |....:|.|....:.:|..|||:|||:||..|||:..|.|.|.::..|:..:.|.:..|||..
Mouse    93 HHNHTGKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAA 157

  Fly   112 GFGGWQAYCGIRVVMGLAQGLVFPCIHHHLAKWSPPAERNRLGALSHTGMECGNVSAMFLSGMIA 176
            .. |......:|.:.||.:|:.||.:|...:.|:||.||::|..:|:.|.:.|.|.::.|||:|.
Mouse   158 DL-GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC 221

  Fly   177 KSAIGWPGISYVSAGLAFAWCAIWFVFAADNAVESRYITQEELHYIESSLKHNEDYHKTVIPVPW 241
             ..:.|..:.|:...:...|..:|....:|.....:.|:..|..||.||||:.....|.   |||
Mouse   222 -YYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSSQKV---VPW 282

  Fly   242 MAIWTSAPFLALTLTRCCATWGLSTLQAQIPTYMNGVLDMDMKSNAFFSALPFLAMWIMSYVYLI 306
            .:|..|.|..|:.:......|...||...:||||..:|..:::.|.|.||||:...|:...:...
Mouse   283 GSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQ 347

  Fly   307 IADVLLAGNRLSLTALRKTFNSLAFWIPCATLIGIGFLDQEQKNLAIALMTISVGVNSGATIGSS 371
            .||.|......|..::|:.|:.:....|...|:..||:..:. :||:|.:|||..:...|:.|.|
Mouse   348 AADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDY-SLAVAFLTISTTLGGFASSGFS 411

  Fly   372 LNTIDLSPNHASILMGILNTAVTVVPIVTPLIVGVIVHEDDNRAEWQIVFIIAAVLFFVGNSVYL 436
            :|.:|::|::|.||:||.||..| :|.:|..|:...:..|:...|||.||.|||.:...|...:.
Mouse   412 INHLDIAPSYAGILLGITNTFAT-IPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFT 475

  Fly   437 YFGTAVSQPWDAEDY 451
            .|.....|.|...|:
Mouse   476 LFAKGEVQSWALSDH 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12490	NP_611722.2	2A0114euk	14..450	CDD:129972	138/456 (30%)
CG12490	NP_611722.2	MFS	54..438	CDD:119392	123/383 (32%)
Slc17a5	NP_766361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Dileucine internalization motif. /evidence=ECO:0000250	22..23
		2A0114euk	30..491	CDD:129972	141/468 (30%)
		MFS	99..478	CDD:119392	123/385 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840