DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12490 and F11A5.9

DIOPT Version :9

Sequence 1:	NP_611722.2	Gene:	CG12490 / 37623	FlyBaseID:	FBgn0034782	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_507089.2	Gene:	F11A5.9 / 180085	WormBaseID:	WBGene00008677	Length:	519	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	114/461 - (24%)
Similarity:	204/461 - (44%)	Gaps:	57/461 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NVGVSVVAMTNAETTNPNFPE-------YDWTEAEKSYIFSSFFWGYILTQFIGGYLCKRFGVKS 91
            |:.:::|..:.:.|.|....|       |:::.:|||.:||....|.::..:....|.::||.:|
Worm    74 NMEMTLVNASGSLTDNVENMEHKIADGRYNYSPSEKSLLFSLVAVGAMVAVYPVMLLIQKFGSRS 138

  Fly    92 VMFWGVFVSGVCSALTPLFIGFGGWQAYCG------IRVVMGLAQGLVFPCIHHHLAKWSPPAER 150
            ::||...:|.|.:||.|       |.||.|      :|...|......|..|.....:||...:.
Worm   139 IVFWVGMLSTVSTALIP-------WMAYIGFWPLLVMRFFQGAGLSTSFTLIGIVTRQWSMQVQS 196

  Fly   151 NRLGALSHTGMECGNVSAMFLSGMIAKSAIGWPGISYVSAGLAFAWCAIWFVFAADNAVESRYIT 215
            ....|:..|..:.|.:..|.::|.:..|::|||.:.|:.|.:.|....:::.|..:|.|....::
Worm   197 AFYIAVLTTFFQIGPIFTMPVAGALCTSSLGWPAVYYIHAVVTFGLFVLFYFFYRENPVRHALVS 261

  Fly   216 QEELHYIESSL---KHNEDYHKTVI--PVPWMAIWTSA--PFLALTLTRCCATWGLSTLQAQIPT 273
            .:||..|:...   |......|.::  ||.| :||.||  .|:.:.|          |:|.. ||
Worm   262 TKELEKIQRGKGDGKREAVPIKAILTDPVIW-SIWISAIGNFMGIQL----------TMQFS-PT 314

  Fly   274 YMNGVLDMDMKSNAFFSALPFLAMWIMSYVYLIIADVLLAGNRLSLTALRKTFNSLAFWIPCATL 338
            |:|.|:...::....|||:|.:..:.:..:....||  .|......|:: |.:|:||......:.
Worm   315 YLNKVMGFAVEQTGTFSAIPQIVTFFLKVIAGYAAD--KARCCTPQTSV-KIYNNLALGGMSLSF 376

  Fly   339 IGIGFLDQEQKNLAIALMTIS---VGVNSGATIGSSLNTIDLSPNHASILMGILNTAVTVVPIVT 400
            :|:..:...:..|.:.::..|   :|.|.||...||   ...:..|...:||:.:....:..::.
Worm   377 LGLAVIPVSEPVLGLCMLIFSCSIIGFNCGAFFRSS---AIYAAQHNHFIMGVNSFLNCLAALLA 438

  Fly   401 PLIVGVIVHEDDNRAEWQIVFIIAAVLFFVGNSVYLYFGTAVSQPWDAEDY--------LTVKVP 457
            |:||.:.| .:|...||..|:::..|..||.|.|:..:|..|...|....:        :.|.||
Worm   439 PVIVNIFV-ANDTWDEWWWVWMVHFVTLFVFNIVFQIYGKGVPAEWSKPGFGRSNVIGDVVVSVP 502

  Fly   458 ELAKVP 463
            :..:||
Worm   503 KTTEVP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12490	NP_611722.2	2A0114euk	14..450	CDD:129972	109/438 (25%)
CG12490	NP_611722.2	MFS	54..438	CDD:119392	102/406 (25%)
F11A5.9	NP_507089.2	2A0114euk	27..486	CDD:129972	109/437 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28615
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820